Abstract
Intravenous infusions are being used with increasing frequency in modern medicine. There are a variety of reasons for this.
-
Administration of drugs by intravenous infusion enables a constant plasma drug con- centration to be maintained. This is especially important with drugs whose therapeutic concentration range is narrow. The plasma concentrations of such drugs when administered as intermittent intravenous boluses are frequently in the toxic range, or too low to be therapeutic. An example of such a drug is theophylline. Theophylline has a minimum therapeutic plasma concentration of 10 mg/L and a minimum toxic plasma concentration of 20 mg/L [5].
-
The dose per unit time of a drug administered by continuous intravenous infusion is lower than if the same drug had been administered intermittently. An example of this is provided by the total dose of midazolam required to maintain hypnosis for a given time. The total dose required to maintain hypnosis is lower when midazolam is administered by constant intravenous infusion, than when administered as intermittent intravenous bolus doses [1].
-
Accurate electronically controlled intravenous infusion pumps are becoming increasingly more available in most modern hospitals. These make the administration of drugs by intravenous infusion much easier.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Lauven PM, et al: Ein pharmakokinetisch begründetes Infusionsmodell für Midazolam. Eine mikroprozessorgesteuerte Applikationsform zur Erreichung konstanter Plasmaspiegel. Der Anaesthesist, 1982: 31: 15–20.
Wagner, J.G., “Fundamentals of Clinical Pharmacokinetics”, published Drug Intelligence Publications, INC., Hamilton, Illinois, U.S.A., 1979, ISBN 0-914678-20-4.
Rigg JRA, Wong TY: A method for achieving rapidly steady-state blood concentrations of i.v. drugs. British Journal of Anaesthesia, 1981: 53: 1247–1257.
Mitenko PA, Ogilvie RI: Rapidly achieved plasma concentration plateaus, with observations on theophylline kinetics. Clinical Pharmacology & Therapeutics, 1972: 13: 329–335.
Hendeles L, Weinberger M: Theophylline. A “state of the art” review. Pharmacotherapy, 1983: 3: 2–44.
Wagner JG: A safe method for rapidly achieving plasma concentration plateaus. Clinical Pharmacology & Therapeutics, 1974: 16: 691–700.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1992 Kluwer Academic Publishers
About this chapter
Cite this chapter
Woerlee, G.M. (1992). Intravenous Infusions. In: Kinetics and Dynamics of Intravenous Anesthetics. Developments in Critical Care Medicine and Anesthesiolgy, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-0-585-28009-7_6
Download citation
DOI: https://doi.org/10.1007/978-0-585-28009-7_6
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-7923-1506-3
Online ISBN: 978-0-585-28009-7
eBook Packages: Springer Book Archive