Practical I.V. Bolus Kinetics & Dynamics

  • Gerald M. Woerlee
Part of the Developments in Critical Care Medicine and Anesthesiolgy book series (DCCA, volume 26)


The previous four chapters have discussed the basic principles of drug kinetics and dynamics. These principles will be applied in this chapter to explain the known clinical properties of anesthetic drugs administered as intermittent intravenous doses. A drug administered as a single rapid intravenous dose is called a bolus intravenous dose.


Distribution Phase Bolus Dose Postoperative Analgesia Repeat Dose Plasma Drug Concentration 
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Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • Gerald M. Woerlee
    • 1
  1. 1.Rijnoord HospitalAlphen aan den RijnThe Netherlands

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