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Multicompartment Kinetic Models

  • Gerald M. Woerlee
Part of the Developments in Critical Care Medicine and Anesthesiolgy book series (DCCA, volume 26)

Abstract

Chapter 2 discussed the basic physiological principles underlying multicompartment pharmacokinetic models while chapter 1 reviewed the basic methods of their mathematical treatment. This chapter will discuss the principles of these models further. Multicompartment models are currently preferred for two important reasons. The data required are readily derived from measurements of blood drug concentrations. Secondly, multicompartment models are not as mathematically complex, and yet yield predictions which are as accurate as those made by physiological models.

Keywords

Drug Concentration Plasma Drug Concentration Elimination Phase Drug Elimination Single Intravenous Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • Gerald M. Woerlee
    • 1
  1. 1.Rijnoord HospitalAlphen aan den RijnThe Netherlands

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