Multicompartment Kinetic Models

  • Gerald M. Woerlee
Part of the Developments in Critical Care Medicine and Anesthesiolgy book series (DCCA, volume 26)


Chapter 2 discussed the basic physiological principles underlying multicompartment pharmacokinetic models while chapter 1 reviewed the basic methods of their mathematical treatment. This chapter will discuss the principles of these models further. Multicompartment models are currently preferred for two important reasons. The data required are readily derived from measurements of blood drug concentrations. Secondly, multicompartment models are not as mathematically complex, and yet yield predictions which are as accurate as those made by physiological models.


Drug Concentration Plasma Drug Concentration Elimination Phase Drug Elimination Single Intravenous Dose 
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Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • Gerald M. Woerlee
    • 1
  1. 1.Rijnoord HospitalAlphen aan den RijnThe Netherlands

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