Multicompartment Kinetic Models
Chapter 2 discussed the basic physiological principles underlying multicompartment pharmacokinetic models while chapter 1 reviewed the basic methods of their mathematical treatment. This chapter will discuss the principles of these models further. Multicompartment models are currently preferred for two important reasons. The data required are readily derived from measurements of blood drug concentrations. Secondly, multicompartment models are not as mathematically complex, and yet yield predictions which are as accurate as those made by physiological models.
KeywordsDrug Concentration Plasma Drug Concentration Elimination Phase Drug Elimination Single Intravenous Dose
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