Physiological Aspects of Drug Kinetics and Dynamics

  • Gerald M. Woerlee
Part of the Developments in Critical Care Medicine and Anesthesiolgy book series (DCCA, volume 26)


Before discussing the pharmacokinetic and pharmacodynamic models in current use, it is well worth discussing their physiological basis. This has several advantages.
  • A physiological approach to drug kinetics describes the actual distribution and elimination of drugs.

  • Anesthesiologists usually view and solve most problems in physiological terms. Therefore such an approach is one which simplifies learning drug kinetics and dynamics by using familiar concepts.

  • An appreciation of the physiological basis of the currently used kinetic and dynamic models makes it easier to predict changes resulting from any disturbance of normal physiology.

  • An appreciation of the physiological basis of drug distribution and elimination also shows some of the limitations of current pharmacokinetic models.


Cardiac Output Pharmacokinetic Model Circulation Time Anesthetic Drug Drug Kinetic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • Gerald M. Woerlee
    • 1
  1. 1.Rijnoord HospitalAlphen aan den RijnThe Netherlands

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