The percentage reaction frequency (%RF) of a patient’s serum is an estimate of the proportion of kidney donors who would react positively in a crossmatch test. The accuracy of this estimate depends on the composition of the test panel and on a number of technical variables. Sequentially tested sera reveal fluctuations in the %RF. These result from changes in the antigenic repertoire of alloantibodies. Expansion of the antigenic repertoire to include larger numbers of antigens gives higher %RF and a narrowing of the range of antigen specificities gives a lower %RF, In this study the practice of monitoring sensitization was compared between six laboratories throughout Europe. In order to achieve comparability complex clinical charts were reduced to simplified sets of symbols. Thereafter sensitization profiles were related to immunizing events.
KeywordsBlood Transfusion Cell Pattern Immunize Event Cell Profile Serological Profile
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