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Signal Transduction In Fungi

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Book cover The Growing Fungus

Abstract

Eukaryotic cell function is dependent on a variety of signalling mechanisms which translate external physicochemical and biochemical stimuli into specific intracellular responses involving second messengers, e.g. Ca2+, cyclic AMP (cAMP), inositol lipids (Figure 9.1). Signal transduction is believed to underpin virtually all important cellular processes, including growth, differentiation and metabolism. In comparison to mammalian, and to a lesser extent plant systems, information on signal transduction in fungi is limited, particularly for filamentous species. However, with the accelerating use of both budding and fission yeast as eukaryotic cell models, considerable progress is being made at the molecular and biochemical level and it is now possible to review general aspects of signal transduction in fungi in the light of other more extensively studied eukaryotic models.

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References

  • Alexandra, J. and Lassalles, J.-P. (1992) Intracellular Ca2+ release by InsPP3 in plants and effect of buffers on Ca2+ diffusion. Philosophical Transactions of the Royal Society, London, 338, 53–61.

    Article  Google Scholar 

  • Anraku, Y., Umemoto, N., Hitara, R. and Wada, Y. (1989) Structure and function of the yeast vacuolar membrane proton ATPase. Journal of Bioenergetics and Biomembranes, 21, 589–603.

    Article  PubMed  CAS  Google Scholar 

  • Anraku, Y., Ohya, Y and Iida, H. (1991) Cell cycle control by calcium and calmodulin in Saccharomyces cerevisiae. Biochimica et Biophysica Ada, 1093, 169–77.

    Article  CAS  Google Scholar 

  • Bartelt, D.C., Fidel, S., Farber, L.H. et al. (1988) Calmodulin-dependent multifunctional protein kinase in Aspergillus nidulans. Proceedings of the National Academy of Sciences of the USA, 85, 3279–83.

    Article  PubMed  CAS  Google Scholar 

  • Baum, P.R., Furlong, C. and Byers, B. (1986) Yeast gene required for spindle pole body duplication: homology of its product with Ca2+-binding proteins. Proceedings of the National Academy of Sciences of the USA, 83, 5512–16.

    Article  PubMed  CAS  Google Scholar 

  • Bazzi, M.D. and Nelsestuen, G.L. (1988) Properties of membrane-inserted protein kinase-C. Biochemistry, 27, 7589–93.

    Article  PubMed  CAS  Google Scholar 

  • Becker, G. and Lester, R. (1980) Biosynthesis of phosphoinositol-containing sphingolipids from phospharidylinositol by a membrane preparation from Saccharomyces cerevisiae. Journal of Bacteriology, 142, 747–54.

    PubMed  CAS  Google Scholar 

  • Bell, R., Loomis, C. and Hannun, Y. (1988) Protein kinase C regulation by sphingosine/lysosphingolipids. Cold Spring Harbor Symposia on Quantitative Biology, 53, 103–110.

    Article  PubMed  CAS  Google Scholar 

  • Berridge, M.J. (1983) Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. Biochemical Journal, 212, 849–58.

    PubMed  CAS  Google Scholar 

  • Berridge, M.J. (1984) Inositol trisphosphate and diacylglycerol as second messengers. Biochemical Journal, 220, 345–60.

    PubMed  CAS  Google Scholar 

  • Berridge, M.J. (1987) Inositol trisphosphate and diacylglycerol: two interacting second messengers. Annual Review of Biochemistry, 56, 159–93.

    Article  PubMed  CAS  Google Scholar 

  • Berridge, M.J. (1993) Inositol trisphosphate and calcium signalling. Nature, 361, 315–25.

    Article  PubMed  CAS  Google Scholar 

  • Berridge, M.J. and Irvine, R.F. (1984) Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature, 312, 315–21.

    Article  PubMed  CAS  Google Scholar 

  • Berridge, M.J. and Irvine, R.F. (1989) Inositol phosphates and cell signalling. Nature, 341, 197–205.

    Article  PubMed  CAS  Google Scholar 

  • Bertyl, A. and Slayman, C.L. (1990) Cation-selective channels in the vacuolar membrane of Saccharomyces: dependence on calcium, redox state, and voltage. Proceedings of the National Academy of Sciences of the USA, 87, 7824–8.

    Article  Google Scholar 

  • Beullens, M., Mbonyi, K., Geerts, L. et al. (1988) Studies on the mechanism of the glucose-induced cAMP-signal in glycolysis-and glucose repression mutants of the yeast Saccharomyces cerevisiae. European Journal of Biochemistry, 172, 227–31.

    Article  PubMed  CAS  Google Scholar 

  • Bourret, J.A. (1986). Evidence that a glucose-mediated rise in cyclic-AMP triggers germination of Pilobolus longipes spores. Experimental Mycology, 10, 60–6.

    Article  CAS  Google Scholar 

  • Bourret, J.A. and Smith, C.M. (1987) Cyclic AMP regulation of glucose transport in germinating Pilobolus longipes spores. Archives of Microbiology, 148, 29–33.

    Article  CAS  Google Scholar 

  • Boutry, M., Foury, F., Goffeau, A. (1977) Energy-dependent uptake of calcium by the yeast Schizosaccharomyces pombe. Biochimica et Biophysica Acta, 464, 602–12.

    Article  PubMed  CAS  Google Scholar 

  • Brewster, J.L., De Valoir, T., Dwyer, N.D. et al. (1993) An osmosensing signal transduction pathway in yeast. Science, 259, 1760–3.

    Article  PubMed  CAS  Google Scholar 

  • Broach, J.R. (1991) RAS genes in Saccharomyces cerevisiae: signal transduction in search of a pathway. Trends in Genetics, 7, 28–33.

    Article  PubMed  CAS  Google Scholar 

  • Broach, J.R. and Deschenes, R.J. (1990) The function of RAS genes in Saccharomyces cerevisiae. Advances in Cancer Research, 54, 79–139.

    Article  PubMed  CAS  Google Scholar 

  • Brockerhoff, S.E. and Davis, T.N. (1992) Calmodulin concentrates at regions of cell growth in Saccharomyces cerevisiae. Journal of Cell Biology, 118, 619–29.

    Article  PubMed  CAS  Google Scholar 

  • Brunton, A.H. and Gadd, G.M. (1989) The effect of exoogenously-supplied nucleosides and nucleotides and the involvement of adenosine 3′:5′-cyclic monophosphate (cyclic AMP) in the yeast-mycelium transition of Ceratocystis (=Ophiostoma) ulmi. FEMS Microbiology Letters, 60, 49–54.

    CAS  Google Scholar 

  • Brunton, A.H. and Gadd, G.M. (1991) Evidence for an inositol lipid signal pathway in the yeast-mycelium transition of Ophiostoma (Ceratocystis) ulmi, the Dutch elm disease fungus. Mycological Research, 95, 484–91.

    Article  CAS  Google Scholar 

  • Busa, W.B. and Nuccitelli, R. (1984) Metabolic regulation via intracellular pH. American Journal of Physiology, 246, R409–38.

    PubMed  CAS  Google Scholar 

  • Cantore, M.L., Galvagno, M.A. and Passeron, S. (1980) Variations in the levels of cyclic adenosine 3′:5′-monophosphate and in the activities of adenylate cyclase and cyclic adenosine 3′:5′-monophosphate phosphodiesterase during aerobic morphogenesis of Mucor rouxii. Archives of Biochemistry and Biophysics, 199, 312–20.

    Article  PubMed  CAS  Google Scholar 

  • Cantore, M.L., Galvagno, M.A. and Passeron, S. (1983) cAMP levels and in situ measurement of adenylate cyclase and cAMP phosphodiesterase activities during yeast-to-hyphae transition in the dimorphic fungus Mucor rouxii. Cell Biology International Reports, 7, 947–54.

    Article  PubMed  CAS  Google Scholar 

  • Carafoli, E. (1987) Intracellular calcium homeostasis. Annual Review of Biochemistry, 56, 395–433.

    Article  PubMed  CAS  Google Scholar 

  • Carafoli, E. and Penniston, J.T. (1985) The calcium signal. Scientific American, 253, 70–116.

    Article  PubMed  CAS  Google Scholar 

  • Carafoli, E., Balcavage, W.X., Lehninger, A.L. and Mattoon, J.R. (1970) Ca2+ metabolism in yeast cells and mitochondria. Biochimica et Biophysica Acta, 205, 18–26.

    Article  PubMed  CAS  Google Scholar 

  • Caspani, G., Tortora, P., Hanozet, G.M. and Guerritore, A. (1985) Glucose-stimulated cAMP increase may be mediated by intracellular acidification in Saccharomyces cerevisiae. FEBS Letters, 186, 75–9.

    Article  CAS  Google Scholar 

  • Chattaway, F.W., Wheeler, P.R. and O’Reilly, J. (1981) Involvement of adenosine 3′:5′-cyclic monophosphate in the germination of blastospores of Candida albicans. Journal of General Microbiology, 123, 233–40.

    PubMed  CAS  Google Scholar 

  • Cheung, W.Y. (1980) Calmodulin plays a pivotal role in cellular regulation. Science, 207, 19–27.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, P. (1992) Signal integration at the level of protein kinases, protein phosphatases and their substrates. Trends in Biochemical Sciences, 17, 408–13.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, P. and Hardie, D.G. (1991) The actions of cyclic AMP on biosynthetic processes are mediated indirectly by cyclic AMP-dependent protein kinase. Biochimica et Biophysica Acta, 1094, 292–9.

    Article  PubMed  CAS  Google Scholar 

  • Colbran, R.J., Smith, R.K., Schworer, C.M. et al. (1989a). Regulatory domain of calcium calmodulin-dependent protein kinase-II-mechanism of inhibition and regulation by phosphorylation. Journal of Biological Chemistry, 264, 4800–4.

    PubMed  CAS  Google Scholar 

  • Colbran, R.J., Schworer, C.M., Hashimoto, Y. et al. (1989b) Calcium calmodulin-dependent protein kinase II. Biochemical Journal, 258, 313–25.

    PubMed  CAS  Google Scholar 

  • Cooper, L.A., Edwards, S.W. and Gadd, G.M. (1985) Involvement of adenosine 3′:5′-cyclic monophosphate in the yeast-mycelium transition of Aureobasidium pullulans. Journal of General Microbiology, 131, 1589–93.

    CAS  Google Scholar 

  • Cornelius, G. and Nakashima, H. (1987) Vacuoles play a decisive role in calcium homeostasis in Neurospora crassa. Journal of General Microbiology, 133, 2341–7.

    CAS  Google Scholar 

  • Cornelius, G., Gebauer, G. and Techel, D. (1989) Inositol trisphosphate induces calcium release from Neurospora crassa vacuoles. Biochemical and Biophysical Research Communications, 162, 852–6.

    Article  PubMed  CAS  Google Scholar 

  • Corzo, A. and Sanders, D. (1992) Inhibition of Ca2+ uptake in Neurospora crassa by La3+: mechanistic study. Journal of General Microbiology, 138, 1791–5.

    Article  CAS  Google Scholar 

  • Crabbe, J.M., Iser, J.R. and Grant, B.R. (1988) Calcium control of differentiation in Phytophthora palmivora. Archives of Microbiology, 149, 565–71.

    Article  Google Scholar 

  • Cyert, M.S. and Thorner, J. (1988) Identification of a calcineurin-like activity in the yeast Saccharomyces cerevisiae. Journal of Cell Biology, 107, 841a.

    Article  Google Scholar 

  • Cyert, M.S. and Thorner, J. (1992) Regulating subunit (CNB1 gene product) of yeast Ca2+ calmodulin-dependent phosphatases is required for adaptation to pheromone. Molecular and Cellular Biology, 12, 3460–9.

    PubMed  CAS  Google Scholar 

  • Cyert, M.S., Kunisawa, R., Kaim, D. and Thorner, J. (1991) Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase. Proceedings of the National Academy of Sciences of the USA, 88, 7376–80.

    Article  PubMed  CAS  Google Scholar 

  • Davis, T.N. (1992) A temperature-sensitive calmodulin mutant loses viability during mitosis. Journal of Cell Biology, 118, 607–17.

    Article  PubMed  CAS  Google Scholar 

  • Davis, T.N., Urdea, M.S., Masiarz, F.R. and Thorner, J. (1986) Isolation of the yeast calmodulin gene: calmodulin is an essential protein. Cell, 47, 423–31.

    Article  PubMed  CAS  Google Scholar 

  • Deacon, J.W. and Donaldson, S.P. (1993) Molecular recognition in the homing responses of zoosporic fungi, with special reference to Pythium and Phytophthora. Mycological Research, 97, 1153–71.

    Article  CAS  Google Scholar 

  • De Vendittis, E., Vitelli, A., Zahn, R. and Fasano, O. (1986) Suppression of defective RAS1 and RAS2 functions in yeast by an adenylate cyclase activated by a single amino acid change. EMBO Journal, 5, 3657–63.

    PubMed  Google Scholar 

  • Dewerchin, M.A. and Van Laere, A.J. (1984) Trehalase activity and cyclic AMP content during early development of Mucor rouxii spores. Journal of Bacteriology, 158, 575–9.

    PubMed  CAS  Google Scholar 

  • Dicker, W. and Turian, G. (1990) Calcium deficiencies and apical hyperbranching in wild-type and ‘frost’ and’ spray’ morphological mutants of Neurospora crassa. Journal of General Microbiology, 136, 1413–20.

    Article  CAS  Google Scholar 

  • Donaldson, S.P. and Deacon, J.W. (1993) Changes in motility of Pythium zoospores induced by calcium and calcium-modulating drugs. Mycological Research, 97, 877–33.

    Article  CAS  Google Scholar 

  • Downes, P. and Michell, R.H. (1982) Phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: lipids in search of a function. Cell Calcium, 3, 467–502.

    Article  PubMed  CAS  Google Scholar 

  • Dumont, J.E., Jauniaux, J.C. and Roger, P.P. (1989) The cyclic AMP-mediated stimulation of cell proliferation. Trends in Biotechnology, 14, 67–71.

    CAS  Google Scholar 

  • Eckstein, H. (1988) 3′:5′-cyclic GMP in the yeast Saccharomyces cerevisiae at different metabolic conditions. FEBS Letters, 232, 121–4.

    Article  PubMed  CAS  Google Scholar 

  • Egidy, G.A., Paveto, M.C., Passeron, S. and Galvagno, M.A. (1989) Relationship between cyclic adenosine 3′:5′-monophosphate and germination in Candida albicans. Experimental Mycology, 13, 428–32.

    Article  CAS  Google Scholar 

  • Eilam, Y. (1982) The effect of monovalent cations on calcium efflux in yeast. Biochimica et Biophysica Ada 687, 8–16.

    Article  CAS  Google Scholar 

  • Eilam, Y. and Chernichovsky, D. (1987), Uptake of Ca2+ driven by the membrane potential in energy-depleted yeast cells. Journal of General Microbiology, 133, 1641–9.

    PubMed  CAS  Google Scholar 

  • Eilam, Y. and Othman, M. (1990) Activation of Ca2++ influx by metabolic substrates in Saccharomyces cerevisiae: role of membrane potential and cellular ATP levels. Journal of General Microbiology, 136, 861–6.

    Article  PubMed  CAS  Google Scholar 

  • Eilam, Y., Lavi. H. and Grossowicz, N. (1985) Cytoplasmic Ca2+ homeostasis maintained by a vacuolar Ca2+ transport system in the yeast Saccharomyces cerevisiae. Journal of General Microbiology, 31, 623–9.

    Google Scholar 

  • Eilam, Y., Othman, M. and Halachmi, D. (1990) Transient increase in Ca2+ influx in Saccharomyces cerevisiae in response to glucose: effects of intracellular acidification and cAMP levels. Journal of General Microbiology, 136, 2537–43.

    Article  PubMed  CAS  Google Scholar 

  • Epstein, L., Staples, R.C. and Hoch, H.C. (1989) Cyclic AMP, cyclic GMP, and bean rust uredospore germlings. Experimental Mycology, 13, 100–4.

    Article  CAS  Google Scholar 

  • Eraso, P., Mazon, M.J. and Gancedo, J.M. (1987) Internal acidification and cAMP increase are not correlated in Saccharomyces cerevisiae. European Journal of Biochemistry, 165, 671–74.

    Article  PubMed  CAS  Google Scholar 

  • Farkaš, V., Sulová, Z. and Lehotstý, J. (1985) Effect of light on the concentration of adenine nucleotides in Trichoderma viride. Journal of General Microbiology, 131, 317–20.

    Google Scholar 

  • Favre, B. and Turian, G. (1987) Identification of a calcium-and phospholipid-dependent protein kinase (protein kinase C) in Neurospora crassa. Plant Science, 49, 15–21.

    Article  CAS  Google Scholar 

  • Field, J., Vojtek, A., Ballester, R. et al. (1990) Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein. Cell, 61, 319–27.

    Article  PubMed  CAS  Google Scholar 

  • Fields, F.O. and Thorner, J. (1989) Biochemical and genetic analysis of protein kinase C (PK-C) function in the yeast Saccharomyces cerevisiae. Genetics Society of America, Yeast Genetics and Molecular Biology Meeting, Atlanta, Georgia, 27 June–1 July 1989, p. 22.

    Google Scholar 

  • Flanagan, C.A. and Thorner, J. (1992) Purification and characterization of a soluble phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae. Journal of Biological Chemistry, 267, 24117–25.

    PubMed  CAS  Google Scholar 

  • Francois, J., Villaneuva, M.E. and Hers, H.G. (1988) The control of glycogen metabolism in yeast. I. Interconversion in vivo of glycogen synthase and glycogen phosphorylase induced by glucose, a nitrogen source or uncouplers. European Journal of Biochemistry, 174, 551–9.

    Article  PubMed  CAS  Google Scholar 

  • Frascotti, G., Baroni, D. and Martegani, E. (1990) The glucose-induced polyphosphoinositides turnover in Saccharomyces cerevisiae is not dependent on the CDC25-RAS mediated signal transduction pathway. FEBS Letters, 274, 19–22.

    Article  PubMed  CAS  Google Scholar 

  • Gadd, G.M. (1988) Carbon nutrition and metabolism, in Physiology of Industrial Fungi, (ed. D.R. Berry), Blackwell Scientific, Oxford, pp. 21–57.

    Google Scholar 

  • Gadd, G.M. and Brunton, A.H. (1992) Calcium involvement in dimorphism of Ophiostoma ulmi, the Dutch elm disease fungus, and characterization of calcium uptake by yeast cells and germ tubes. Journal of General Microbiology, 138, 1561–71.

    Article  CAS  Google Scholar 

  • Gancedo, C. and Serrano, R. (1989) Energy-yielding metabolism, in The Yeasts, Vol. 3, Metabolism and Physiology of Yeasts, (eds A.H. Rose and J.S. Harrison) Academic Press, London, pp. 205–59.

    Google Scholar 

  • Gancedo, J.M., Mazon, MJ. and Eraso, P. (1985) Biological roles of cyclic AMP: similarities and differences between organisms. Trends in Biochemical Sciences, 10, 210–12.

    Article  CAS  Google Scholar 

  • Garrill, A., Lew, R.R. and Brent Heath, I. (1992) Stretch-activated Ca2+ and Ca2+-activated K+ channels in the hyphal tip plasma membrane of the oomycete Saprolegnia ferax. Journal of Cell Science, 101, 721–30.

    CAS  Google Scholar 

  • Garrill, A., Jackson, S.L., Lew, R.R. and Brent Heath, I. (1993) Ion channel activity and tip growth: tip localised stretch-activated channels generate an essential Ca2+ gradient in the oomycete Saprolegnia ferax. European Journal of Cell Biology, 60, 358–65.

    PubMed  CAS  Google Scholar 

  • Geiser, J.R., Van Tuinen, D., Brockerhoff, S.E. et al. (1991) Can calmodulin function without binding calcium? Cell, 65, 949–59.

    Article  PubMed  CAS  Google Scholar 

  • Ghislain, M., Schlesser, A. and Goffeau, A. (1987) Mutation of a conserved glycine residue modifies the vanadate sensitivity of the plasma-membrane H+-ATPase from Schizosaccharomyces pombe. Journal of Biological Chemistry, 262, 17549–55.

    PubMed  CAS  Google Scholar 

  • Ghislain, M., Goffean, A., Halachmi, D. and Eilam, Y. (1990) Calcium homeostasis and transport are affected by disruption of eta3, a novel gene encoding Ca2+-ATPase in Schizosaccharomyces pombe. Journal of Biological Chemistry, 265, 18400–7.

    PubMed  CAS  Google Scholar 

  • Gibbs, G.B. and Marshall, M.S. (1989) The ras oncogene — an important regulatory element in lower eucaryotic organisms. Microbiological Reviews, 53, 171–85.

    PubMed  CAS  Google Scholar 

  • Gimeno, C.J., Ljungdahl, P.O., Styles, C.A. and Fink, G.R. (1992) Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell, 68, 1077–90.

    Article  PubMed  CAS  Google Scholar 

  • Goffeau, A., Ghislain, M., Navarre, C. et al. (1990) Novel transport ATPases in yeast. Biochimica et Biophysica Ada, 1018, 200–2.

    Article  CAS  Google Scholar 

  • Gooday, G.W. and Adams, D.J. (1993) Sex hormones and fungi. Advances in Microbial Physiology, 34, 69–145.

    Article  PubMed  CAS  Google Scholar 

  • Grešík, M., Nadežda, K. and Farkaš, V. (1988) Membrane potential, ATP and cyclic AMP changes induced by light in Trichoderma viride. Experimental Mycology, 12, 295–301.

    Article  Google Scholar 

  • Griffith, J.M., Iser, J.R. and Grant, B.R. (1988) Calcium control of differentiation in Phytophthora palmivora. Archives of Microbiology, 149, 565–71.

    Article  CAS  Google Scholar 

  • Gupta, P. and Prasad, R. (1993) Levels of plasma membrane H+-ATPase do not change during growth and morphogenesis of Candida albicans. FEMS Microbiology Letters, 106, 165–70.

    Article  PubMed  CAS  Google Scholar 

  • Gustin, M.C., Martinac, B., Saimi, Y. et al. (1986) Ion channels in yeast. Science, 233, 1195–7.

    Article  PubMed  CAS  Google Scholar 

  • Gustin, M.C., Zhou, X.-L., Martinac, B. and Kung, C. (1988) A mechanosensitive ion channel in the yeast plasma membrane. Science, 242, 762–5.

    Article  PubMed  CAS  Google Scholar 

  • Halachmi, D. and Eilam, Y. (1989) Cytosolic and vacuolar Ca2+ concentrations in yeast-cells measured with the Ca2+-sensitive fluorescence dye Indo-1. FEBS Letters, 256, 55–61.

    Article  PubMed  CAS  Google Scholar 

  • Halachmi, D. and Eilam, Y. (1993) Calcium homeostasis in yeast cells exposed to high concentrations of calcium. FEBS Letters, 316, 73–8.

    Article  PubMed  CAS  Google Scholar 

  • Halachmi, D., Ghislain, M. and Eilam, Y. (1992) An intracellular ATP-dependent calcium pump within the yeast Schizosaccharomyces pombe, encoded by the gene cta3. European Journal of Biochemistry, 207, 1003–8.

    Article  PubMed  CAS  Google Scholar 

  • Hanson, B.A. (1984) Role of inositol-containing sphingolipids in Saccharomyces cerevisiae during inositol starvation. Journal of Bacteriology, 159, 837–42.

    PubMed  CAS  Google Scholar 

  • Hanson, B.A. (1991) The effects of lithium on the phosphoinositides and inositol phosphates of Neurospora crassa. Experimental Mycology, 15, 76–90.

    Article  CAS  Google Scholar 

  • Hashiba, T. (1982) Sclerotial morphogenesis in the rice sheath blight fungus (Rhizoctonia solani). Bulletin of the Hokuriku National Agricultural Experimental Station (Japan), 24, 29–83.

    Google Scholar 

  • Hashiba, T. and Ishikawa, T. (1978) Effect of adenosine 3′,5′-cydic monophosphate on induction of sclerotia in Rhizoctonia solani. Phytopathology, 65, 159–62.

    Article  Google Scholar 

  • Hiraga, K., Suzuki, K., Tsuchiya, E. and Miyakawa, T. (1993) Identification and characterization of nuclear calmodulin-binding proteins of Saccharomyces cerevisiae. Biochimica et Biophysica Ada, 1177, 25–30.

    Article  CAS  Google Scholar 

  • Hirimburegama, K., Durnez, P., Keleman, J. et al. Nutrient-induced activation of trehalase in nutrient-starved cells of the yeast Saccharomyces cerevisiae: cAMP is not involved as second messenger. Journal of General Microbiology, 138, 2035–43.

    Google Scholar 

  • Hoch, H.C. and Staples, R.C. (1984) Evidence that cyclic AMP initiates nuclear division and infection structure formation in the bean rust fungus Uromyces phaseoli. Experimental Mycology, 8, 37–46.

    Article  CAS  Google Scholar 

  • Hoch, H.C. and Staples, R.C. (1991) Signaling for infection structure formation in fungi, in The Fungal Spore and Disease Initiation in Plants and Animals (eds G.T. Cole and H.C. Hoch), Plenum Press, New York, pp. 25–46.

    Google Scholar 

  • Holmes, A.R., Cannon, R.D. and Shepherd, M.G. (1991) Effect of calcium ion uptake on Candida albicans morphology. FEMS Microbiology Letters, 77, 187–94.

    Article  CAS  Google Scholar 

  • Holzer, H. (1984) Mechanism and function of reversible phosphorylation of fructose-1,6-bisphosphate in yeast, in Molecular Aspects of Cellular Regulation, vol. 3 (ed. P. Cohen), Elsevier, Amsterdam, pp. 143–54.

    Google Scholar 

  • Hoshino, T., Mizutani, A., Shimizu, S. et al (1991) Calcium ion regulates the release of lipase of Fusarium oxysporum. Journal of Biochemistry, 110, 457–61.

    PubMed  CAS  Google Scholar 

  • Hubbard, M., Bradley, N., Sullivan, P. et al. (1982) Evidence of the occurrence of calmodulin in the yeasts Candida albicans and Saccharomyces cerevisiae. FEBS Utters, 317, 85–8.

    Article  Google Scholar 

  • Iida, H., Yagaura, Y. and Anraku, Y. (1990a) Essential role for induced Ca2+ influx followed by [Ca2]i rise in maintaining viability of yeast cells late in the mating pheromone response pathway. Journal of Biological Chemistry, 265, 13391–9.

    PubMed  CAS  Google Scholar 

  • Iida, H., Sakaguchi, S., Yagawa, Y. and Anraku, Y. (1990b) Cell cycle control by Ca2+ in Saccharomyces cerevisiae. Journal of Biological Chemistry, 265, 21216–22.

    PubMed  CAS  Google Scholar 

  • Jackson, S.L. and Heath, I.B. (1989) Effects of exogenous calcium ions on tip growth, intracellular Ca2+ concentration, and actin arrays in hyphae of the fungus Saprolegnia ferax. Experimental Mycology, 13, 1–12.

    Article  Google Scholar 

  • Jackson, S.L. and Heath, I.B. (1993) Roles of calcium ions in hyphal tip growth. Microbiological Reviews, 57, 367–82.

    PubMed  CAS  Google Scholar 

  • Janssens, P.M.W. (1987) Did vertebrate signal transduction mechanisms originate in eukaryotic microbes? Trends in Biochemical Sciences, 12, 456–9.

    Article  CAS  Google Scholar 

  • Johannes, E., Brosnan, J.M. and Sanders, D. (1991) Calcium channels and signal transduction in plant cells. BioEssays, 13, 331–6.

    Article  Google Scholar 

  • Johannes, E., Brosnan, J.M. and Sanders, D. (1992) Calcium channels in the vacuolar membrane of plants: multiple pathways for intracellular calcium mobilization. Philosophical Transactions of the Royal Society, London, 338, 105–12.

    Article  CAS  Google Scholar 

  • Jones, B.E. and Bu’Lock, J.D. (1977) The effect of N 6, O 2,-dibutyryl adenosine-3’,5’-cydic monophosphate on morphogenesis in Mucorales. Journal of General Microbiology, 103, 29–36.

    Article  CAS  Google Scholar 

  • Jones, R.P. and Gadd, G.M. (1990) Ionic nutrition of yeast — the physiological mechanisms involved and applications for biotechnology. Enzyme and Microbial Technology, 12, 402–18.

    Article  CAS  Google Scholar 

  • Kaibuchi, K., Miyajima, A., Arai, K.-I. and Matsumoto, K. (1986) Possible involvement of RAS-encoded proteins in glucose-enduced inositol phospholipid turnover in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the USA, 83, 8172–6.

    Article  PubMed  CAS  Google Scholar 

  • Kamihari, T. and Omi, K. (1989) Increase in cyclic AMP content with enhanced phosphatidylinositol turnover in the cells of Candida tropicalis during mycelial growth caused by ethanol. Yeast, 5, 437–40.

    Google Scholar 

  • Kato, H., Uno, I., Ishikawa, T. and Takenawa, T. (1989) Activation of phosphatidylinositol kinase and phosphatidylinositol-4-phosphate kinase by cAMP in Saccharomyces cerevisiae. Journal of Biological Chemistry, 264, 3116–21.

    PubMed  CAS  Google Scholar 

  • Kaur, S. and Mishra, P. (1991) Dimorphism-associated changes in plasma membrane H+-ATPase activity of Candida albicans. Archives of Microbiology, 156, 412–15.

    Article  PubMed  CAS  Google Scholar 

  • Kaur, S., Mishra, P. and Prasad, R. (1988) Dimorphism-associated changes in intracellular pH of Candida albicans. Biochimica et Biophysica Acta, 972, 277–82.

    PubMed  CAS  Google Scholar 

  • Kincaid, R. (1993) Calmodulin-dependent protein phosphatases from microorganisms to man. A study in structural conservatism and biological diversity. Advances in Second Messenger and Phosphoprotein Research, 27, 1–23.

    PubMed  CAS  Google Scholar 

  • Kinney, A.J. and Carman, G.M. (1990) Enzymes of phosphoinositide synthesis in secretary vesicles destined for the plasma membrane in Saccharomyces cerevisiae. Journal of Bacteriology, 172, 4115–17.

    PubMed  CAS  Google Scholar 

  • Kitamoto, K., Yoshizawa, K., Ohsumi, Y. and Anraku, Y. (1988) Mutants of Saccharomyces cerevisiae with defective vacuolar function. Journal of Bacteriology, 170, 2687–91.

    PubMed  CAS  Google Scholar 

  • Klionsky, D.J., Herman, P.K. and Emr, S.D. (1990) The fungal vacuole: composition, function and biogenesis. Microbiological Reviews, 54, 266–92.

    PubMed  CAS  Google Scholar 

  • Konopka, J.B. and Fields, S. (1992) The pheromone signal pathway in Saccharomyces cerevisiae. Antonie van Leeuwenhoek, 62, 95–108.

    Article  PubMed  CAS  Google Scholar 

  • Kovac, L. (1985) Calcium and Saccharomyces cerevisiae. Biochimica et Biophysica Acta, 840, 317–23.

    Article  CAS  Google Scholar 

  • Kozak, K.R. and Ross, I.K. (1991) Signal transduction in Coprinus congregatus — evidence for the involvement of G-proteins in blue-light photomorphogenesis. Biochemical and Biophysical Research Communications, 179, 1225–31.

    Article  PubMed  CAS  Google Scholar 

  • Kurjan, J. (1992) Pheromone response in yeast. Annual Review of Biochemistry, 61, 1097–129.

    Article  PubMed  CAS  Google Scholar 

  • Laccetti, L., Staples, R.C. and Hoch, H.C. (1987) Purification of calmodulin from bean rust uredospores. Experimental Mycology, 11, 231–5.

    Article  CAS  Google Scholar 

  • Lakin-Thomas, P.L. (1993) Evidence against a direct role for inositol phosphate metabolism in the circadian oscillator and the blue-light signal transduction pathway in Neurospora crassa. Biochemical Journal, 292, 813–18.

    PubMed  CAS  Google Scholar 

  • Lakin-Thomas, P.L., Cote, G.G. and Brody, S. (1990) Circadian rhythyms in Neurospora crassa — biochemistry and genetics. Critical Reviews in Microbiology, 17, 365–416.

    Article  PubMed  CAS  Google Scholar 

  • Larsen, A.D. and Sypherd, P.S. (1974) Cyclic adenosine 3′,5′-monophosphate and morphogenesis in Mucor racemosus. Journal of Bacteriology, 117, 432–8.

    PubMed  CAS  Google Scholar 

  • Laychock, S.G. (1989) Coordinate interactions of cyclic nucleotide and phospholipid metabolizing pathways in calcium-dependent cellular processes. Current Topics in Cellular Regulation, 30, 203–42.

    PubMed  CAS  Google Scholar 

  • Levin, D.E., Fields, F.O., Kunisawa, R. et al. (1990) A candidate protein kinase C gene (PKC1) is required for the S. cerevisiae cell cycle. Cell, 62, 213–24.

    Article  PubMed  CAS  Google Scholar 

  • Liao, H.H. and Thorner, J. (1981) Adenosine 3′,5′-phosphate phosphodiesterase and pheromone response in the yeast Saccharomyces cerevisiae. Journal of Bacteriology, 148, 919–25.

    PubMed  CAS  Google Scholar 

  • Lichko, L. and Okorokov, L. (1991) Purification and some properties of membrane-bound and soluble pyrophosphatases of yeast vacuoles. Yeast, 7, 805–12.

    Article  PubMed  CAS  Google Scholar 

  • Liu, Y., Ohki, Y.A., Azuma, Y. et al. (1990) Calmodulin and calmodulin-binding proteins of Rhododsporidium toruloides, a basidiomycetous yeast. Journal of General Microbiology, 136, 131–6.

    Article  CAS  Google Scholar 

  • Londesborough, J. (1989) Purification of a Ca2+/calmodulin-dependent protein kinase from baker’s yeast. Journal of General Microbiology, 135, 3373–83.

    CAS  Google Scholar 

  • Luan, Y., Matsuura, I., Yazawa, M. et al. (1987) Yeast calmodulin: structural and functional differences compared with vertebrate calmodulin. Journal of Biochemistry, 102, 1531–7.

    PubMed  CAS  Google Scholar 

  • Luttrell, B.M. (1993) The biological relevance of the binding of calcium ions by inositol phosphates. Journal of Biological Chemistry, 268, 1521–4.

    PubMed  CAS  Google Scholar 

  • McGillivray, A.M. and Gow, N.A.R. (1987) The transhyphal electrical current of Neurospora crassa is carried principally by protons. Journal of General Microbiology, 133, 2875–81.

    Google Scholar 

  • Magae, Y. (1993) Purification and characterization of protein kinase C from Pleurotus ostreatus. Journal of General Microbiology, 139, 165–9.

    Article  CAS  Google Scholar 

  • Magae, Y. and Magae, J. (1993) Effect of staurosporine on growth and hyphal morphology of Pleurotus ostreatus. Journal of General Microbiology, 139, 161–4.

    Article  CAS  Google Scholar 

  • Magalhăes, B.P., Wayne, R., Humber, R.A. et al. (1991) Calcium-regulation appressorium formation of the entomopathogenic fungus Zoophthora radicans. Protoplasma, 160, 77–88.

    Article  Google Scholar 

  • Matsumoto, K., Uno, I., Toh-e, A. et al. (1982) Cyclic AMP may not be involved in catabolic repression in Saccharomyces cerevisiae: evidence from mutants capable of utilizing it as an adenine source. Journal of Bacteriology, 150, 277–85.

    PubMed  CAS  Google Scholar 

  • Matsumoto, K., Uno, I. and Ishikawa, T. (1985) Genetic analysis of the role of cAMP in yeast. Yeast, 1, 15–24.

    Article  PubMed  CAS  Google Scholar 

  • Mbonyi, K., Beullens, M., Detremerie, K. et al. (1988) Requirement of one functional RAS gene and inability of an oncogenic ras variant to mediate the glucose-induced cyclic AMP signal in the yeast Saccharomyces cerevisiae. Molecular and Cellular Biology, 8, 3051–7.

    PubMed  CAS  Google Scholar 

  • Mbonyi, K., Van Aelst, L., Arguelles, J.C. et al. (1990) Glucose-induced hyperaccumulation of cyclic AMP and defective glucose repression in yeast strains with reduced activity of cyclic AMP-dependent protein kinase. Molecular and Cellular Biology, 10, 4518–23.

    PubMed  CAS  Google Scholar 

  • Means, A.R., Van Berkum, M.F.A., Bagchi, I. et al. (1991). Regulatory function of calmodulin. Pharmacological Therapy, 50, 255–70.

    Article  CAS  Google Scholar 

  • Meikle, A.J., Reed, R.H. and Gadd, G.M. (1988) Osmotic adjustment and the accumulation of organic solutes in whole cells and protoplasts of Saccharomyces cerevisiae. Journal of General Microbiology, 134, 3049–60.

    PubMed  CAS  Google Scholar 

  • Michell, R.H. (1975) Inositol phospholipids and cell surface receptor function. Biochimica et Biophysica Ada, 415, 81–147.

    Article  CAS  Google Scholar 

  • Michell, R.H., Kirk, C.J., Jones, L.M. et al. (1981) The stimulation of inositol phospholipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions. Philosophical Transactions of the Royal Society of London, Series B, 296, 123–37.

    Article  CAS  Google Scholar 

  • Miller, A.J., Vogg, G. and Sanders, D. (1990) Cytosolic calcium homeostasis in fungi: roles of plasma membrane transport and intracellular sequestration of calcium. Proceedings of the National Academy of Sciences of the USA, 87, 9348–52.

    Article  PubMed  CAS  Google Scholar 

  • Miyakawa, T., Oka, Y., Tsuchiya, E. and Fukui, S. (1989) Saccharomyces cerevisiae protein kinase dependent on Ca2+ and calmodulin. Journal of Bacteriology, 171,1417–22.

    PubMed  CAS  Google Scholar 

  • Miyamoto, S., Ohya, Y., Ohsumi, Y. and Anraku, Y. (1987) Nucleotide sequence of the CLS4 (CDC24) gene of Saccharomyces cerevisiae. Gene, 54, 125–32.

    Article  PubMed  CAS  Google Scholar 

  • Monk, B.C., Kurtz, M.B., Marrinan, J.A. and Perlin, D.S. (1991) Cloning and characterization of the plasma membrane H+-ATPase from Candida albicans. Journal of Bacteriology, 173, 6826–36.

    PubMed  CAS  Google Scholar 

  • Monk, B.C., Niimi, M. and Shepherd, M.G. (1993) The Candida albicans plasma membrane and H+-ATPase during yeast growth and germ tube formation. Journal of Bacteriology, 175, 5566–74.

    PubMed  CAS  Google Scholar 

  • Morales, M. and Ruiz-Herrera, J. (1989) Subcellular localization of calcium in sporangiosphores of Phycomyces blakesleeanus. Archives of Microbiology, 152, 468–72.

    Article  CAS  Google Scholar 

  • Moreno, S., Galvagno, M.A. and Passeron, S. (1982) Control of Mucor rouxii adenosine 3′:3′-monophosphate phosphodiesterase by phosphorylation-dephosphorylation and proteolysis. Archives of Biochemistry and Biophysics, 214, 573–80.

    Article  PubMed  CAS  Google Scholar 

  • Munder, T. and Kuntzel, H. (1989) Glucose-induced cAMP signaling in Saccharomyces cerevisiae is mediated by the CDC25 protein. FEBS Letters, 242, 341–5.

    Article  PubMed  CAS  Google Scholar 

  • Muthukumar, G. and Nickerson, K.W. (1984) Ca(II)-calmodulin regulation of fungal dimorphism in Ceratocystis ulmi. FEMS Microbiology Letters, 159, 309–92.

    Google Scholar 

  • Muthukumar, G. and Nickerson, K.W. (1985) Ca(II)-calmodulin regulation of morphological commitment in Ceratocystis ulmi. FEMS Microbiology Letters, 27, 199–202.

    Article  CAS  Google Scholar 

  • Muthukumar, G., Luby, M.T. and Nickerson, K.W. (1986) Calmodulin activity in yeast and mycelial phases of Ceratocystis ulmi. FEMS Microbiology Letters, 37, 313–16.

    Article  CAS  Google Scholar 

  • Muthukumar, G., Nickerson, A.W. and Nickerson, K.W. (1987) Calmodulin levels in yeasts and filamentous fungi. FEMS Microbiology Letters, 41, 253–8.

    Article  CAS  Google Scholar 

  • Neer, E.J. and Clapham, D.E. (1988) Role of G protein subunits in transmembrane signalling. Nature, 333, 129–34.

    Article  PubMed  CAS  Google Scholar 

  • Niimi, M. (1984) The glucose effect in Candida albicans. Fukuoka Ada Medica, 75, 356–65.

    CAS  Google Scholar 

  • Niimi, N., Niimi, K., Tokunaga, J. and Nakayama, H. (1980) Changes in cyclic nucleotide levels and dimorphic transition in Candida albicans. Journal of Bacteriology, 142, 1010–14.

    PubMed  CAS  Google Scholar 

  • Nishizuka, Y. (1984) Protein kinases in signal transduction. Trends in Biochemical Sciences, 4, 163–6.

    Article  Google Scholar 

  • Nishizuka, Y. (1988) The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature, 334, 661–5.

    Article  PubMed  CAS  Google Scholar 

  • Nishizuka, Y. (1992a) Signal transduction: crosstalk. Trends in Biochemical Sciences, 17, 367.

    Article  Google Scholar 

  • Nishizuka, Y. (1992b) Intracellular signalling by hydrolysis of phospholipids and activation of protein kinase C. Science, 258, 607–14.

    Article  PubMed  CAS  Google Scholar 

  • O’Day, D.H. (1990) Calcium as an intracellular messenger in eucaryotic microbes, in Calcium as an Intracellular Messenger in Eucaryotic Microbes, (ed. D.H. O’Day), American Society for Microbiology, Washington, DC, pp. 3–13.

    Google Scholar 

  • Ogita, K., Miyamoto, S., Koide, H. et al. (1990) Protein kinase C in Saccharomyces cerevisiae: comparison with the mammalian enzyme. Proceedings of the National Academy of Sciences of the USA, 87, 5011–15.

    Article  PubMed  CAS  Google Scholar 

  • Ohsumi, Y. and Anraku, Y. (1983) Calcium transport driven by a proton motive force in vacuolar membrane vesicles of Saccharomyces cerevisiae. Journal of Biological Chemistry, 41, 17–22.

    Google Scholar 

  • Ohsumi, Y., Kitamoto, K. and Anraku, Y. (1988) Changes induced in the permeability barrier of the yeast plasma membrane by cupric ion. Journal of Bacteriology, 170, 2676–82.

    PubMed  CAS  Google Scholar 

  • Ohya, Y. and Anraku, Y. (1989) Functional expression of chicken calmodulin in yeast. Biochemical and Biophysical Research Communications, 158, 541–7.

    Article  PubMed  CAS  Google Scholar 

  • Ohya, Y. and Anraku, Y. (1992) Yeast calmodulin: structural and functional elements essential for the cell cycle. Cell Calcium, 13, 445–55.

    Article  PubMed  CAS  Google Scholar 

  • Ohya, Y., Ohsumi, Y. and Anraku, Y. (1986a) Isolation and characterization of Ca2+-sensitive mutants of Saccharomyces cerevisiae. Journal of General Microbiology, 132, 979–88.

    PubMed  CAS  Google Scholar 

  • Ohya, Y., Miyamoto, Y., Ohsumi, Y. and Anraku, Y. (1986b) Calcium-sensitive cls4 mutant of S. cerevisiae with a defect in bud formation. Journal of Bacteriology, 165, 28–33.

    PubMed  CAS  Google Scholar 

  • Ohya, Y., Umemoto, N., Tanida, I. et al. (1991a). Calcium-sensitive c/s mutants of Saccharomyces cerevisiae showing a Pet-phenotype are ascribable to defects of vacuolar membrane H+-ATPase activity. Journal of Biological Chemistry, 266, 13971–7.

    PubMed  CAS  Google Scholar 

  • Ohya, Y., Kawasaki, H., Suzuki, K. et al. (1991b). Two yeast genes encoding calmodulin-dependent protein kinases. Journal of Biological Chemistry, 266, 12784–94.

    PubMed  CAS  Google Scholar 

  • Okorokov, L.A. (1985) Main mechanism of ion transport and regulation of ion concentrations in the yeast cytoplasm, in Environmental Regulation of Microbial Metabolism, (eds I.S Kulaev, E.A. Dawes and D.W. Tempest), Academic Press, London, pp. 339–49.

    Google Scholar 

  • Orlowski, M. and Ross, J.R. (1981) Relationship of internal cyclic AMP levels, rates of protein synthesis and Mucor dimorphism. Archives of Microbiology, 129, 353–6.

    Article  PubMed  CAS  Google Scholar 

  • Ortega Perez, R., Van Tuinen, D., Marme, D. et al. (1981) Purification and identification of calmodulin from Neurospora crassa. FEBS Letters, 133, 205–8.

    Article  PubMed  CAS  Google Scholar 

  • Pall, M. (1977) Cyclic AMP and the plasma membrane potential in Neurospora crassa. Journal of Biological Chemistry, 252, 7146–50.

    PubMed  CAS  Google Scholar 

  • Pall, M.L. (1981), Adenosine 3′,5′-phosphate in fungi. Microbiological Reviews, 45, 462–480.

    PubMed  CAS  Google Scholar 

  • Pall, M.L. (1984), Is there a general paradigm of cyclic AMP action in eukaryotes? Molecular and Cellular Biochemistry, 58, 187–91.

    Article  PubMed  CAS  Google Scholar 

  • Pall, M.L. and Robertson, C.K. (1986) Cyclic AMP control of hierarchical growth pattern of hyphae in Neurospora crassa. Experimental Mycology, 10, 161–5.

    Article  CAS  Google Scholar 

  • Paranjape, V. and Datta, A. (1990) Role of calcium and calmodulin in morphogenesis of Candida albicans, in Calcium as an Intracellular Messenger in Eukaryotic Cells, (ed. D.H. O’Day), American Society for Microbiology, Washington DC, pp. 362–74.

    Google Scholar 

  • Paranjape, V., Roy, B.G. and Datta, A. (1990) Involvement of calcium, calmodulin and protein phosphorylation in morphogenesis of Candida albicans. Journal of General Microbiology, 136, 2149–54.

    Article  PubMed  CAS  Google Scholar 

  • dos Passos, J.B., Vanhalewyn, M., Brandao, R.L. et al. (1992) Glucose-induced activation of plasma membrane H+-ATPase in mutants of the yeast Saccharomyces cerevisiae affected in cAMP metabolism, cAMP-dependent protein phosphorylation and the initiation of glycolysis. Biochimica et Biophysica Acta, 1136, 57–67.

    Article  PubMed  Google Scholar 

  • Paveto, C., Epstein, A. and Passeron, S. (1975) Studies on cyclic adenosine 3′,5′-monophosphate levels, adenylate cyclase and phosphodiesterase activities in the dimorphic fungus Mucor rouxii. Archives of Biochemistry and Biophysics, 169, 449–57.

    Article  PubMed  CAS  Google Scholar 

  • Pietrobon, D., Di Virgilio, F.D. and Pozzan, T. (1990) Structural and functional aspects of calcium homeostasis in eukaryotic cells. European Journal of Biochemistry, 193, 599–62.

    Article  PubMed  CAS  Google Scholar 

  • Pitt, D. and Ugalde, U.O. (1984) Calcium in fungi. Plant, Cell and Environment, 7, 467–75.

    Article  CAS  Google Scholar 

  • Pitt, D. and Kaile, A. (1990) Transduction of the calcium signal with special reference to Ca2+ induced conidiation in Penicillium notatum, in Biochemistry of Cell Walls and Membranes of Fungi, (eds, P.J. Kuhn, A.P.J. Trinci, M. Jung et al.) Springer Verlag, Berlin, pp. 283–98.

    Chapter  Google Scholar 

  • Powers, P.A. and Pall, M.L. (1980) Cyclic AMP-dependent protein kinase of Neurospora crassa. Biochemical and Biophysical Research Communications, 95, 701–6.

    Article  PubMed  CAS  Google Scholar 

  • Pringle, J.R. and Hartwell, L.H. (1981) The Saccharomyces cerevisiae cell cycle, in, The Molecular Biology of the Yeast Saccharomyce, Metabolism and Gene Expression (eds J.N. Strathern, E.W. Jones and J.R. Broach), Cold Spring Harbour Laboratory, Cold Spring Harbor, pp. 97–142.

    Google Scholar 

  • Prior, S.L., Cunnliffe, B.W., Robson, G.D. and Trinci, A.P.J. (1993) Multiple isomers of phosphatidyl inositol monophosphate and inositol bis-and trisphosphates from filamentous fungi. FEMS Microbiology Letters, 110, 147–52.

    Article  PubMed  CAS  Google Scholar 

  • Rasmussen, H. and Rasmussen, J.E. (1990) Calcium as intracellular messenger: from simplicity to complexity. Current Topics in Cellular Regulation, 31, 1–109.

    PubMed  CAS  Google Scholar 

  • Rea, P. A., Kim, Y., Sarafian, V. et al. (1992) Vacuolar H+-translocating pyrophosphatases — a new category of ion translocase. Trends in Biochemical Sciences, 17, 348–53.

    Article  PubMed  CAS  Google Scholar 

  • Reissig, J.L. and Kinney, S.G. (1983) Calcium as a branching signal in Neurospora crassa. Journal of Bacteriology, 154, 1397–402.

    PubMed  CAS  Google Scholar 

  • Rivera-Rodriguez, N. and Rodriguez-del Valle, N. (1992) Effects of calcium ions on the germination of Sporothrix schenckii conidia. Journal of Medical and Veterinary Mycology, 30, 185–95.

    Article  PubMed  CAS  Google Scholar 

  • Robson, G.D., Wiebe, M.G. and Trinci, A.P.J. (1991a), Involvement of Ca2+ in the regulation of hyphal extension and branching in Fusarium graminearum A3/5. Experimental Mycology, 15, 263–72.

    Article  CAS  Google Scholar 

  • Robson, G.D., Wiebe, M.G. and Trinci, A.P.J. (1991b) Low calcium concentrations induce increased branching in Fusarium graminearum. Mycological Research, 95, 561–5.

    Article  CAS  Google Scholar 

  • Robson, G.D., Wiebe, M.G. and Trinci, A.P.J. (1991c) Exogenous cAMP and cGMP modulate branching in Fusarium graminearum. Journal of General Microbiology, 137, 963–9.

    Article  PubMed  CAS  Google Scholar 

  • Robson, G.D., Trinci, A.P.J., Wiebe, M.G. and Best, L.C. (1991d) Phosphatidylinositol 4,5-bisphosphate (PIP2) is present in Fusarium graminearum. Mycological Research, 95, 1082–4.

    Article  CAS  Google Scholar 

  • Rose, M.D. and Vallen, E.A. (1991) Acid loops fail the acid test. Cell, 65, 919–20.

    Article  PubMed  CAS  Google Scholar 

  • Rosenberg, G.B. and Pall, MX. (1978) Cyclic AMP and cyclic GMP in germinating conidia of Neurospora crassa. Archives of Microbiology, 118, 87–90.

    Article  PubMed  CAS  Google Scholar 

  • Rosenberg, G.B. and Pall, M.L. (1979) Properties of two cyclic nucleotide deficient mutants of Neurospora crassa. Journal of Bacteriology, 137, 1140–4.

    PubMed  CAS  Google Scholar 

  • Rosenberg, G.B. and Pall, M.L. (1983) Characterization of an ATP-Mg2+ dependent guanine nudeotide-stimulated adenylate cyclase from Neurospora crassa. Archives of Biochemistry and Biophysics, 221, 243–53.

    Article  PubMed  CAS  Google Scholar 

  • Rudolph, H.K., Antebi, A., Fink, G.R. et al. (1989) The yeast secretory pathway is perturbed by mutations in PMR1, a member of a Ca2+-ATPase family. Cell, 58, 133–45.

    Article  PubMed  CAS  Google Scholar 

  • Sabie, F.T. and Gadd, G.M. (1989) Involvement of a Ca2+-calmodulin interaction in the yeast-mycelial transition of Candida albicans. Mycopathologia, 108, 47–54.

    Article  PubMed  CAS  Google Scholar 

  • Sabie, F.T. and Gadd, G.M. (1992) Effect of nucleosides and nucleotides and the relationship between cellular adenosine 3′:5′-cyclic monophosphate (cyclic AMP) and germ tube formation in Candida albicans. Mycopathologia, 119, 147–56.

    Article  PubMed  CAS  Google Scholar 

  • Sanders, D. (1990) Kinetic modelling of plant and fungal membrane transport systems. Annual Review of Plant Physiology and Plant Molecular Biology, 41, 77–107.

    Article  CAS  Google Scholar 

  • Sanders, D., Miller, A.J., Blackford, S. et al. (1990) Cytosolic free calcium homeostasis in plants. Current Topics in Plant Biochemistry and Physiology, 9, 20–37.

    CAS  Google Scholar 

  • Saporito, S.M. and Sypherd, P.S. (1991) The isolation and characterization of a calmodulin-encoding gene (CMD1) from the dimorphic fungus Candida albicans. Gene, 106, 43–9.

    Article  PubMed  CAS  Google Scholar 

  • Sass, P., Field, J., Nikawa, J. et al. (1986) Cloning and characterization of the high-affinity cAMP phosphodiesterase of S. cerevisiae. Proceedings of National Academy of Sciences of the USA, 83, 9303–7.

    Article  CAS  Google Scholar 

  • Schmid, J. and Harold, F.M. (1988) Dual roles for calcium ions in apical growth of Neurospora crassa. Journal of General Microbiology, 134, 2623–31.

    PubMed  CAS  Google Scholar 

  • Schmitt, H.D., Wagner, P., Pfaff, E. and Gallwitz, D. (1986) The ras-related YPT1 gene product in yeast: a GTP-binding protein that might be involved in microtubule organization. Cell, 47, 401–12.

    Article  PubMed  CAS  Google Scholar 

  • Schomerus, C. and Kuntzel, H. (1992) CDC25-dependent induction of inositol 1,4,5-trisphosphate and diacylglycerol in Saccharomyces cerevisiae by nitrogen. FEBS Letters, 307, 249–52.

    Article  PubMed  CAS  Google Scholar 

  • Scott, W.A. and Solomon, B. (1975) Adenosine 3′,5′-cyclic monophosphate and morphology in Neurospora crassa: drug-induced alterations. Journal of Bacteriology, 122, 454–63.

    PubMed  CAS  Google Scholar 

  • Sharada, K., Ikegami, H. and Hyakumachi, M. (1992) 2;4-D induced c-AMP mediated, sclerotial formation in Rhizoctonia solani. Mycological Research, 96, 863–6.

    Article  CAS  Google Scholar 

  • Shaw, N.M. and Harding, R.W. (1983) Calcium inhibition of a heat-stable cydic nudeotide phosphodiesterase from Neurospora crassa. FEBS Letters, 152, 295–9.

    Article  PubMed  CAS  Google Scholar 

  • Shaw, N.M. and Harding, R.W. (1987) Intracellular and extracellular cyclic nucleotides in wild-type and white collar mutant strains of Neurospora crassa. Temperature dependent efflux of cyclic AMP from mycelia. Plant Physiology, 83, 377–83.

    Article  PubMed  CAS  Google Scholar 

  • Shimanuki, M., Kinoshita, N., Ohruka, H. et al. (1993) Isolation and characterization of the fission yeast protein phosphatase gene ppel+ involved in cell shape control and mitosis. Molecular Biology of the Cell, 4, 303–13.

    PubMed  CAS  Google Scholar 

  • Slayman, C.L., Kaminski, P. and Stetson, D. (1990) Structure and function of fungal plasma-membrane ATPases, in Biochemistry of Cell Walls and Membranes in Fungi, (eds P.J. Kuhn, A.P.J. Trinci, M.J. Jung, et al.), Springer-Verlag, Berlin, pp. 299–316.

    Chapter  Google Scholar 

  • Sneddon, A.A. and Stark, M.J.R. (1991) Yeast-protein serine-threonine phosphatase genes and cell division cycle control. Advances in Protein Phosphatases, 6, 307–30.

    CAS  Google Scholar 

  • Sokolovsky, V.S. and Kritsky, M.S. (1985) Photo-regulation of cyclic AMP phosphodiesterase activity of Neurospora crassa. Biochemistry (Russian), 282, 1017–20.

    Google Scholar 

  • St Leger, R.J., Roberts, D.W. and Staples, R.C. (1989) Calcium-and calmodulin-mediated protein synethesis and protein phosphorylation during germination, growth and protease production by Metarhizium anisopliae. Journal of General Microbiology, 135, 2141–54.

    CAS  Google Scholar 

  • St Leger, R.J., Butt, T.M., Staples, R.C. and Roberts, D.W. (1990) Second messenger involvement in differentiation of the entomopathogenic fungus Metarhizium anisopliae. Journal of General Microbiology, 136, 1779–89.

    Article  CAS  Google Scholar 

  • Steele, G.C. and Trinci, A.P.J. (1975) Morphology and growth kinetics of differentiated and undifferentiated mycelia of Neurospora crassa. Journal of General Microbiology, 91, 362–8.

    Article  PubMed  CAS  Google Scholar 

  • Stewart, E., Gow, N.A.R. and Bowen, D.V. (1988) Cytoplasmic alkalinization during germ tube formation in Candida albicans. Journal of General Microbiology, 134, 1079–87.

    PubMed  CAS  Google Scholar 

  • Stewart, E., Hawser, S. and Gow, N.A.R. (1989) Changes in internal and external pH accompanying growth of Candida albicans: studies of non-dimorphic variants. Archives of Microbiology, 151, 149–53.

    Article  PubMed  CAS  Google Scholar 

  • Stirling, D.A., Petrie, A., Pulford, D.J. et al. (1992) Protein A — calmodulin fusions: a novel approach for investigating calmodulin function in yeast. Molecular Microbiology, 6, 703–13.

    Article  PubMed  CAS  Google Scholar 

  • Styrkársdóttir, U., Egel, R. and Nielsen, O. (1992) Functional conservation between Schizosaccharomyces pombe ste8 and Saccharomyces cerevisiae STE11 protein kinases in yeast signal transduction. Molecular and General Genetics, 235, 122–30.

    Article  PubMed  Google Scholar 

  • Suoranta, K. and Londesborough, J. (1984) Purification of intact and nicked forms of a zinc-containing, Mg2+-dependent, low Km cyclic AMP phosphodiesterase from baker’s yeast. Journal of Biological Chemistry, 259, 6964–71.

    PubMed  CAS  Google Scholar 

  • Tachikawa, T., Miyakawa, T., Tsuchiya, E. and Fukiu, S. (1987) A rapid and transient increase of cellular Ca2+ in response to mating pheromone in Saccharomyces cerevisiae. Agricultural and Biological Chemistry, 51, 1209–10.

    Article  CAS  Google Scholar 

  • Takeda, T. and Yamamoto, M. (1987) Analysis and in vivo disruption of the gene coding of calmodulin in Schizosaccharomyces pombe. Proceedings of the National Academy of Sciences of the USA, 84, 3580–4.

    Article  PubMed  CAS  Google Scholar 

  • Terenzi, H.F., Flawia, M.M., Tellez-Inon, M.T. and Torres, H.N. (1976) Control of Neurospora crassa morphology by cyclic adenosine 3′,5′-monophosphate and dibutyryl cyclic adenosine 3′,5′-monophosphate. Journal of Bacteriology, 126, 91–9.

    PubMed  CAS  Google Scholar 

  • Terenzi, H.F., Jorge, J.A., Roselino, J.E. and Migliorini, R.H. (1979) Adenylyl cyclase deficient cr-l (crisp) mutant of Neurospora crassa: cyclic AMP-dependent nutritional deficiencies. Archives of Microbiology, 123, 251–8.

    Article  PubMed  CAS  Google Scholar 

  • Terenzi, H., Terenzi, H.F. and Jorge, J.A. (1992) Effect of cyclic AMP on invertase activity in Neurospora crassa. Journal of General Microbiology, 138, 2433–9.

    Article  CAS  Google Scholar 

  • Thevelein, J.M. (1984) Regulation of trehalose mobilization in fungi. Microbiological Reviews, 48, 42–59.

    PubMed  CAS  Google Scholar 

  • Thevelein, J.M. (1988) Regulation of trehalase activity by phosphorylation-dephosphorylation during developmental transitions in fungi. Experimental Mycology, 12, 1–12.

    Article  CAS  Google Scholar 

  • Thevelein, J.M. (1991) Fermentable sugars and intracellular acidification as specific activators of the RAS adenylate cyclase signalling pathway in yeast — the relationship to nutrient induced cell cycle control. Molecular Microbiology, 5, 1301–7.

    Article  PubMed  CAS  Google Scholar 

  • Thevelein, J.M. (1992) The RAS-adenylate cyclase pathway and cell cycle control in Saccharomyces cerevisiae. Antonie van Leeuwenhoek, 62, 109–30.

    Article  PubMed  CAS  Google Scholar 

  • Thevelein, J.M. and Beullens, M. (1985) Cyclic AMP and the stimulation of trehalase activity in the yeast Saccharomyces cerevisiae by carbon sources, nitrogen sources and inhibitors of protein synthesis. Journal of General Microbiology, 131, 3199–209.

    PubMed  CAS  Google Scholar 

  • Thevelein, J.M., Beullens, M., Honshoven, F. et al. (1987a) Regulation of the cAMP level in the yeast Saccharomyces cerevisiae: intracellular pH and the effect of membrane depolarizing compounds. Journal of General Microbiology, 133, 2191–6.

    PubMed  CAS  Google Scholar 

  • Thevelein, J.M., Beullens, M., Honshoven, F. et al. (1987b) Regulation of the cAMP signal in the yeast Saccharomyces cerevisiae: the glucose-induced cAMP signal is not mediated by a transient drop in the intracellular pH. Journal of General Microbiology, 133, 2197–205.

    PubMed  CAS  Google Scholar 

  • Thiel, R., Schreurs, W.J.A. and Harold, F.M. (1988) Transcellular ion currents during sporangium development in the water mould Achlya bisexualis. Journal of General Microbiology, 134, 1089–97.

    PubMed  CAS  Google Scholar 

  • Thorner, J., Fields, F.O., Kunisawa, R. and Levin, D. (1988) Protein kinase C (PKC) is an essential enzyme in the yeast Saccharomyces cerevisiae. Journal of Cell Biology, 107, 443a.

    Google Scholar 

  • Toda, T., Uno, I., Ishikawa, T. et al. (1985) In yeast, Ras proteins are controlling elements of adenylate cyclase. Cell, 40, 27–36.

    Article  PubMed  CAS  Google Scholar 

  • Toda, T., Cameron, S., Sass, P. et al. (1987) Three different genes in Saccharomyces cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell, 50, 277–87.

    Article  PubMed  CAS  Google Scholar 

  • Tomes, C. and Moreno, S. (1990) Phosphodiesterase activity and cyclic AMP content during early germination of Mucor rouxii spores. Experimental Mycology, 14, 78–83.

    Article  CAS  Google Scholar 

  • Trevillyan, J.M. and Pall, M.X. (1979) Control of cyclic adenosine 3′,5′ monophosphate levels by depolarizing agents in fungi. Journal of Bacteriology, 1, 397–403.

    Google Scholar 

  • Trevillyan, J.M. and Pall, M.L. (1982) Isolation and properties of a cyclic AMP-binding protein from Neurospora — evidence for its role as the regulatory subunit of cyclic AMP-dependent protein kinase. Journal of Biological Chemistry, 257, 3978–86.

    PubMed  CAS  Google Scholar 

  • Trinci, A.P.J., Robson, G.D., Wiebe, M.G. et al. (1990) Growth and morphology of Fusarium graminearum and other fungi in batch and continuous culture, in Microbial Growth Dynamics, (eds R.K. Poole, M.J. Bazin and C.W. Keevil), IRL Press, Oxford, pp. 17–38.

    Google Scholar 

  • Tsunoda, Y. (1991). Oscillatory Ca2+ signalling and its cellular functions. New Biologist, 3, 3–17.

    PubMed  CAS  Google Scholar 

  • Turian, G. and Favre, B. (1990) Calcium-and phospholipid-phospholipid-dependent protein and lipid kinases in Neurospora crassa, in Calcium as an Intracellular Messenger in Eucaryotic Microbes, (ed D.H. O’Day), American Society for Microbiology, Washington, DC, pp. 165–91.

    Google Scholar 

  • Ugalde, U.O., Virto, M.D. and Pitt, D. (1990) Calcium binding and induction of conidiation in protoplasts of Penicillium cyclopium. Antonie van Leeuwenhoek, 57, 43–9.

    Article  PubMed  CAS  Google Scholar 

  • Ulaszewski, S., Hilger, F. and Goffeau, A. (1989) Cyclic AMP controls the plasma membrane H+-ATPase activity from Saccharomyces cerevisiae. FEBS Letters, 245, 131–6.

    Article  PubMed  CAS  Google Scholar 

  • Uno, I. and Ishikawa, T. (1981) Control of adenosine 3′,5′-monophosphate level and protein phosphorylation by depolarizing agents in Coprinus macrorhizus. Biochimica el Biophysica Ada, 672, 108–13.

    Article  CAS  Google Scholar 

  • Uno, I. and Ishikawa, T. (1990) Role of phosphatidylinositol metabolites in proliferation of yeast cells, in Calcium as an Intracellular Messenger in Eukaryotic Cells, (ed. D.H. O’Day), American Society for Microbiology, Washington, DC, pp. 52–64.

    Google Scholar 

  • Uno, L., Ishikawa, T. and Hashiba, T. (1985a) Cyclic AMP-dependent phosphorylation of proteins in mycelia of Rhizodonia solani forming sclerotia. Annals of the Phytopathological Society of Japan, 51, 190–8.

    Article  CAS  Google Scholar 

  • Uno, L., Ishikawa, T. and Hashiba, T. (1985b) Detection of cAMP levels and cyclic AMP-receptor protein in mycelia of Rhizodonia solani forming sclerotia. Annals of the Phytopathological Society of Japan, 51, 183–

    Article  CAS  Google Scholar 

  • Uno, I., Fukami, K., Kato, H. et al. (1988) Essential role for phosphatidylinositol 4,5-bisphosphate in yeast cell proliferation. Nature, 33, 188–90.

    Article  Google Scholar 

  • Uno, I., Ohya, Y., Anraku, Y. and Ishikawa, T. (1989) Cell cycle-dependent regulation of calmodulin levels in Saccharomyces cerevisiae. Journal of General and Applied Microbiology, 35, 59–63.

    Article  CAS  Google Scholar 

  • Van Aelst, L., Boy-Marcotte, E., Camonis, J.H. et al. (1990) The C-terminal part of the CDC25 gene product plays a key role in signal transduction in the glucose-induced modulation of cAMP level in Saccharomyces cerevisiae. European Journal of Biochemistry, 193, 675–80.

    Article  PubMed  Google Scholar 

  • Van Aelst, L., Jans, A.W.H. and Thevelein, J.M. (1991) Involvement of the CDC25 gene product in the signal transmission pathway of the glucose-induced RAS-mediated cAMP signal in the yeast Saccharomyces cerevisiae. Journal of General Microbiology 137, 341–9.

    Article  PubMed  Google Scholar 

  • Van Laere, A.J. (1986a) Cyclic AMP, phosphodiesterase, and spore activation in Phycomyces blakesleeanus. Experimental Mycology, 10, 52–9.

    Article  Google Scholar 

  • Van Laere, A.J. (1986b) Biochemistry of spore germination in Phycomyces. FEMS Microbiology Reviews, 32, 189–98.

    Google Scholar 

  • Van Mulders, A.R. and Van Laere, A.J. (1984) Cyclic AMP, trehalase and germination of Phycomycees blakesleanus spores. Journal of General Microbiology, 130, 541–7.

    Google Scholar 

  • Van Tuinen, D., Ortega Perez, R., Marine, D. and Turian, G. (1984) Calcium, calmodulin-dependent protein phosphorylation in Neurospora crassa. FEBS Letters, 176, 317–20.

    Article  Google Scholar 

  • Van Zyl, W., Huang, W., Sneddon, A.A. et al. (1992) Inactivation of the protein phosphatase 2A regulating subunit A results in morphological and transcriptional defects in Saccharomyces cerevisiae. Molecular and Cellular Biology, 12, 4946–59.

    PubMed  Google Scholar 

  • Verdier, J.M., Camonis, J.H. and Jacquet, M. (1989) Cloning of CDC33: a gene essential for growth and sporulation which does not interfere with cAMP production of Saccharomyces cerevisiae. Yeast, 5, 79–90.

    Article  PubMed  CAS  Google Scholar 

  • Wada, Y., Ohsumi, Y. and Anraku, Y. (1986) Mechanisms of acidification of the vacuolar membrane vesicles from Saccharomyces cerevisiae: effects of inorganic anions. Cell Structure and Function, 11, 533.

    Google Scholar 

  • Wada, Y., Ohsumi, Y., Tanifuji, M. et al. (1987) Vacuolar channel of the yeast Saccharomyces cerevisiae. Journal of Biological Chemistry, 262, 17260–3.

    PubMed  CAS  Google Scholar 

  • White, C. and Gadd, G.M. (1987) The uptake and cellular distribution of zinc in Saccharomyces cerevisiae. Journal of General Microbiology 133, 727–37.

    CAS  Google Scholar 

  • Yoko-o, T., Matsui, Y., Yagisawa, H. (1993) The putative phosphoinositide-specific phospholipase C gene, PLCl, of the yeast Saccharomyces cerevisiae is important for cell growth. Proceedings of the National Academy of Sciences of the USA, 90, 1804–8.

    Article  PubMed  CAS  Google Scholar 

  • Yoshida, S., Ikeda, E., Uno, I. and Mitsuzawa, H. (1992) Characterization of a staurosporine-and temperature-sensitive mutant, stt1, of Saccharomyces cerevisiae: STT1 is allelic to PKC1. Molecular and General Genetics, 231, 337–44.

    Article  PubMed  CAS  Google Scholar 

  • Youatt, J. (1993) Calcium and microorganisms. Critical Reviews in Microbiology, 19, 83–97.

    Article  PubMed  CAS  Google Scholar 

  • Zhou, X.-L., Stumpf, M.A., Hoch, H.C. and Kung, C. (1991) A mechanosensitive channel in whole cells and in membrane patches of the fungus Uromyces. Science, 253, 1415–17.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Biological Sciences, University of Dundee, Dundee, UK

    G. M. Gadd

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  1. Department of Molecular and Cell Biology, University of Aberdeen, Aberdeen, UK

    Neil A. R. Gow

  2. Department of Biological Sciences, University of Dundee, Dundee, UK

    Geoffrey M. Gadd

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© 1995 Neil A.R. Gow and Geoffrey M. Gadd

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Gadd, G.M. (1995). Signal Transduction In Fungi. In: Gow, N.A.R., Gadd, G.M. (eds) The Growing Fungus. Springer, Dordrecht. https://doi.org/10.1007/978-0-585-27576-5_9

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