The Cell Cycle

  • Martin Beckerman
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Cells are continually exposed to a host of agents that can damage DNA and cause cancer. In response, cells have evolved a trio of interlocking cancer barrier systems. The first-line barrier system is an integrated multicomponent DNA damage detection, cell cycle arrest, and repair system. This system halts the orderly progression through the cell cycle once damage is detected to allow time for repair, and when the repairs are completed the cell cycle is allowed to proceed. If the cell is subjected to excessive DNA damage and stresses, and inappropriate growth may occur, the cell is not allowed to proceed through the cell cycle. Rather, it either undergoes apoptosis (the second barrier) to remove a possibly dangerous cell, or the cell is put into a state of permanent growth arrest, or senescence (the third barrier).

Mechanistically, unscheduled growth stimuli and/or agents such as radiation and reactive oxygen species give rise to DNA damage and stalled replication forks. These stresses...


Cell Cycle Cdk1 Activity Pocket Protein Sister Chromatid Separation Maturation Promote Factor 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Oak RidgeUSA

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