Chronic Inflammation

  • Martin Beckerman
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

The emergence of inflammation as a major ingredient in the development of atherosclerosis has parallels in other disease states and classes. It is a contributing factor to cancer, especially metastasis, and can be either beneficial or harmful in neurodegeneration. Like atherosclerotic tissues, the microenvironments of other diseased tissues contain leukocytes, pro-inflammatory cytokines, and additional potentially harmful agents such as reactive oxygen species. Multiple initiating factors can trigger the loss of tissue homeostasis including injury, metabolic syndrome-associated loss of glucose and lipid homeostasis, malfunctions in growth and cell death regulation, and aggregation-prone misfolded proteins. These factors stimulate and interact with inflammation and its attendant effects lead over time to self-sustaining disease states associated with atherosclerosis, cancers, and neurodegenerative disorders.

The goal of this chapter is to examine the intracellular signaling routes that...


Mesenchymal Stem Cell Nuclear Receptor Stromal Vascular Fraction Ankyrin Repeat Adipose Tissue Macrophage 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Oak RidgeUSA

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