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Metastasis

  • Martin Beckerman
Chapter
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Metastasis begins with the invasion of tumor cells into its surrounding tissue, the stroma. This initial event is followed by migration into the circulation, or intravasation, homing to distant sites, followed by extravasation, seeding and colonization. Deciphering the mechanisms of how, step by step, a cancer cell can leave the site of a primary tumor to seed a colony at a secondary site represents one of the great challenges of science today. It is estimated that about 90% of all cancer deaths arise from cancers that have metastasized. At present there are few successes in treatment interspersed among the far larger number of failures to substantially impede the spread and ensuing deaths.

Given its importance it is not surprising that considerable efforts have been made to better understand metastasis. Two major themes have emerged from these studies. The first is the ascendency of the microenvironment to a place where it must be considered co-equally with the primary tumor cell in...

Keywords

Cancer Stem Cell Actin Cytoskeleton Focal Adhesion Kinase Focal Adhesion Adenomatous Polyposis Coli 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Oak RidgeUSA

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