Tumor Metabolism

  • Martin Beckerman
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Changes in metabolic strategy must accompany the transition from modest growth and proliferation that characterizes normal, healthy cells to the rapid expansion that typifies cancerous growth and proliferation. These changes are made possible by alterations in the signaling pathways that govern and synchronize metabolism and growth, protect against inappropriate growth, and integrate the interlocking growth and metabolic demands with attendant intracellular stress responses and conditions prevalent in the tumor microenvironment.

Signals from at least four pathways coordinately regulate growth and metabolism. Growth factor receptor activation stimulates signaling through the MAP kinase growth and Akt survival pathways as was discussed in the last chapter. Energy balance is maintained by signaling through the AMPK pathway as was discussed in Chapter 2, and yet another pathway conveys information on amino acid status. These signals all converge onto the mTOR signaling cassette. That...


Aerobic Glycolysis Adenine Nucleotide Translocator PTEN Tumor Suppressor Preinitiation Complex Amino Acid Deprivation 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Oak RidgeUSA

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