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Tumor Growth

  • Martin Beckerman
Chapter
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

The focus in the discussions of the preceding two chapters was on the three anticancer barriers – DNA damage repair, apoptosis, and senescence. In those discussions, tumor suppressors such as p53 and pRb had a prominent role along with some of the cell cycle checkpointing and DNA damage repair proteins. The emphasis now shifts in this and the following two chapters to growth and metastasis, and the associated oncogenes. This second phase of the examination of cancer begins with tyrosine kinases required for cell-to-cell signaling and coordination. It then shifts to the downstream components of the central growth and survival pathways. Cancerous growth can only be sustained through modifications in cellular metabolism. The discussion of tumor growth continues into the next chapter with an exploration of how tumor cells adjust their metabolism to support and sustain rapid growth and proliferation.

The microenvironment plays a central role in development of a cancer. That involvement is...

Keywords

Epidermal Growth Factor Receptor Docking Site Mitogen Activate Protein Kinase Kinase Inactive Conformation Upstream Binding Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Oak RidgeUSA

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