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Growth Factors on Biomaterial Scaffolds

  • Yoshihiro Ito
Chapter

Abstract

Growth factors act on cells via endocrine, paracrine, autocrine, intracrine, juxtacrine, and matricrine mechanisms. Four of these mechanisms are diffusible, and two are nondiffusible. Signal transduction of the diffusible growth factors is significantly different from that of the nondiffusible growth factors. It is important to design growth factors for tissue engineering, regenerative medicine, and cell culture systems by considering the mechanisms of their action at the cellular and molecular level. The action mechanism and the utilization of growth factors are discussed.

Keywords

Vascular Endothelial Growth Factor Nerve Growth Factor Hepatocyte Growth Factor Soluble Growth Factor Micropatterned Surface 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

bFGF

Basic fibroblast growth factor

BMP

Bone morphogenic protein

CBD

Collagen-binding domain

CBEGF

Collagen-binding EGF

CB-FGF

Collagen-binding FGF

CHO

Chinese ovary cell

CSF-1

Colony stimulating factor-1

EGF

Epidermal growth factor

ELP

Elastin-like peptide

HB-EGF

Heparin-binding epidermal growth factor

HGF

Hepatocyte growth factor

HUVEC

Human umbilical vein endothelial cell

IL-1ra

Interleukin-1 receptor antagonist

LPS

Lipopolysaccharide

MAPK

Mitogen-activated protein kinase

NGF

Nerve growth factor

PC12

Rat adrenal pheochromocytoma cell line

RGD

Arg–Gly–Asp, a cell adhesive peptide sequence

RGDS

Arg–Gly–Asp-Ser, a cell adhesive peptide sequence

TGF-β

Transforming growth factor-β

THP-1

A monocytic cell line

TMD7

A human leukemia cell line established from blast cells

TNF

Tumor necrosis factor

TrkA

Tyrosine kinase A

UT-7/Epo

A cell line established from the bone marrow; growth is supported byerythropoietin

VEGF

Vascular endothelial growth factor

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Yoshihiro Ito
    • 1
  1. 1.Nano Medical Engineering LaboratoryRIKEN Advanced Science InstituteSaitamaJapan

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