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Inflammatory Response to Implanted Nanostructured Materials

  • Kristy M. Ainslie
  • Rahul G. Thakar
  • Daniel A. Bernards
  • Tejal A. Desai
Chapter

Abstract

Nanostructured materials are implanted for dynamic application in therapies such as drug delivery, tissue engineering, biosensing, and imaging. The interaction between nanostructured materials and the tissues of the body can be used to alter cellular attachment and motility, detect analytes in vivo, and simulate tissue organization. These interactions may also lead to a variety of adverse immune responses, such as acute inflammation and fibrous encapsulation. Nanostructured surfaces have been shown to attenuate the acute inflammatory response of immune cells to a material, as well as change the normal encapsulation response that generally results in implants being quarantined by a wall of cells. Additionally, many of these novel materials improve the time course of wound healing in vivo. In general, nanostructured materials are equally or less immunogenic than a planar surface of the same material. However, much like the basis of material biocompatibility, further studies need to be completed on a per material basis to properly evaluate the inflammation potential of novel nanomaterials.

Keywords

Nanostructured Material Danger Signal Electron Beam Lithography Nanostructured Surface Alumina Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CX3CL1

chemokine ligand 1

CXCL2

chemokine ligand 2

CXCL3

chemokine ligand 3

CXCL10

chemokine ligand 10

EBL

electron beam lithography

ECM

extracellular matrix

GM-CSF

granulocyte-macrophage colony-stimulating factor

IL-6

interleukin six

IL-8

interleukin eight

MIP-1α

macrophage inflammatory protein 1 alpha

MIP-1β

macrophage inflammatory protein 1 beta

MCP-1

monocyte chemotactic protein-1

MSC

marrow stromal cells

PCL

poly(caprolactone)

PDMS

poly(dimethylsiloxane)

PHBV

poly(3-hydroxybutyrate-co-3-valerate)

PLGA

poly(lactide-co-glycolide)

PMMA

poly(methylmethacrylate)

PTFE

poly(tetrafluoroethylene)

RANTES

regulated upon activation, normal T-cell expressed and secreted

ROS

reactive oxygen species

TNF-α

tumor necrosis factor alpha

TGF-β

transforming growth factor-beta

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Kristy M. Ainslie
    • 1
  • Rahul G. Thakar
    • 1
  • Daniel A. Bernards
    • 1
  • Tejal A. Desai
    • 1
  1. 1.Department of Physiology Division of BioengineeringUniversity of California–San FranciscoSan FranciscoUSA

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