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Hydrogel Nanocomposites in Biology and Medicine: Applications and Interactions

  • Nitin S. Satarkar
  • Ashley M. Hawkins
  • J. Zach Hilt
Chapter

Abstract

Hydrogel nanocomposites are a new class of biomaterials that have recently attracted a lot of attention for applications in medical and pharmaceutical areas. The nanocomposites may consist of various types of nanoparticles, such as clay, ceramic, metallic, or metal oxides dispersed in a hydrogel matrix. The hydrogel nanocomposites have been investigated for various biological applications including drug delivery, tissue engineering, antimicrobial materials, and thermal therapy. In particular, different techniques to control the drug release rate from the nanocomposite matrix have been highlighted. In this chapter, various tissue-engineering areas are discussed, including bone, articular cartilage, and cornea repair. Biological interactions with nanocomposites, including cell adhesion and pertinent cytotoxicity studies, are also discussed.

Keywords

Drug Release Lower Critical Solution Temperature Composite Hydrogel Hydrogel Network Hydrogel Nanocomposites 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

ALP

alkaline phosphate

AMF

alternating magnetic field

DC

direct current

HA

hydroxyapatite

HEMA

hydroxyethylmethacrylate

HepG2

human hepatoma cells

pHEMA

poly(hydroxyethylmethacrylate)

IR

infrared

LCST

lower critical solution temperature

MTT

3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

n-HAp

nanohydroxyapatite

PNIPAAm

poly(N-isopropylacrylamide)

PVA

poly(vinyl alcohol)

RC

remote controlled

RGR

relative growth rate

SPH

super porous hydrogel

SPHC

super porous hydrogel composite

TCP

tricalcium phosphate

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Nitin S. Satarkar
    • 1
  • Ashley M. Hawkins
    • 1
  • J. Zach Hilt
    • 1
  1. 1.Department of Chemical and Materials EngineeringUniversity of KentuckyLexingtonUSA

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