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Biomimetic Nanophase Materials to Promote New Tissue Formation for Tissue-Engineering Applications

  • Xiaohua Liu
  • Ian O. Smith
  • Peter X. Ma
Chapter

Abstract

One important aspect of tissue engineering is the development of new biomaterials to facilitate cell–material interactions, which can be achieved by mimicking certain advantageous features of natural extracellular matrix (ECM). Biomimetic nanoscale materials mimic the natural ECM and can be used as scaffolds to provide a better environment for new tissue formation. This chapter focuses on biomimetic nanoscale materials for tissue engineering. First, several techniques are introduced for the fabrication of nanophase scaffolds, which mimic the physical architecture of natural ECM. Second, the role of surface modification in mimicking the chemical composition of natural ECM is discussed. Two novel surface-modification techniques are presented to illustrate the process of fabricating biomimetic scaffolds that mimic both the physical architecture and chemical composition of natural collagen type I. Finally, the biological effects of the nanoarchitecture of scaffolds, such as protein interaction and cell function, including cell attachment, proliferation, and differentiation, are discussed.

Keywords

Simulated Body Fluid Composite Scaffold Nanofibrous Scaffold Polymer Scaffold Scaffold Surface 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

2D

two-dimensional

3D

three-dimensional

BSP

bone sialoprotein

CaP

calcium phosphates

ECM

extracellular matrix

HA

hydroxyapatite

NF-PLLA

nanofibrous poly(l-lactic acid)

PDAC

poly(diallyldimethylammonium chloride)

PHB

poly(3-hydroxybutyrate)

PLA

poly(lactic acid)

PLGA

poly(lactic-co-glycolic acid)

PLLA

poly(l-lactic acid)

RGD

Arg–Gly–Asp

SBF

simulated body fluid

THF

tetrahydrofuran

TIPS

thermally induced phase separation

TRITC

tetramethyl rhodamine iso-thiocyanate

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Xiaohua Liu
    • 1
  • Ian O. Smith
    • 1
  • Peter X. Ma
    • 1
  1. 1.Department of Biologic and Materials SciencesThe University of Michigan,Ann ArborUSA

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