In Vitro and In Vivo Monocyte, Macrophage, Foreign Body Giant Cell, and Lymphocyte Interactions with Biomaterials

  • James M. Anderson


This chapter focuses on recent developments in our understanding of in vitro and in vivo monocyte, macrophage, foreign body giant cell (FBGC), and lymphocyte interactions with biomaterials in the context of inflammatory and wound-healing responses following implantation of biomaterials, medical devices, and prostheses. Quantitative studies identify the significance of biomaterial surface chemistry in modulating inflammatory cell behaviors such as adhesion, apoptosis, anoikis, fusion, and cytokine secretion. Utilizing genomic and proteomic techniques, cell-cell (juxtacrine) and cytokine-mediated (paracrine) responses between cells have been identified. Consequences of the persistence of the foreign body reaction, i.e., macrophages and FBGCs, at the tissue-material interface are presented. Given the current and future use of new approaches, such as nanotechnology and tissue engineering, the continuing development of a mechanistic understanding of inflammatory cell interactions with biomaterials is necessary.


Focal Adhesion Kinase Foreign Body Reaction Mannose Receptor Soluble Mediator Foreign Body Giant Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



dendritic cell-specific transmembrane protein


extracellular matrix


extracellular signal-regulated kinase


foreign body giant cell


focal adhesion kinase


granulocyte colony-stimulating factor


granulocyte macrophage colony-stimulating factor


growth-related oncogene/keratinocyte chemoattractant


intercellular adhesion molecule






interleukin-1 receptor antagonist


lymphocyte function-associated antigen






monocyte chemoattractant protein


Cmacrophage-derived chemokine


macrophage inhibitory protein


macrophage inflammatory proteins


matrix metalloproteinase


messenger RNA


natural killer cells


natural killer T cells


platelet-derived growth factor




platelet factor 4


regulated upon activation, normal T-cell expressed and secreted


real-time polymerase chain reaction


T-cell receptor


transforming growth factor


tissue inhibitor of metalloproteinase


tumor necrosis factor


very late antigen receptor


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • James M. Anderson
    • 1
  1. 1.Departments of Pathology and Biomedical EngineeringCase Western Reserve UniversityClevelandUSA

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