Cell and Tissue Interactions with Materials: The Role of Growth Factors



Realization and appreciation that growth factors are essential in tissue development, regeneration, and maintenance as well as crucial mediators/regulators of pertinent cellular- and molecular-level events has motivated new directions in bioengineering research. These endeavors have the potential of seminal contributions in implant biomaterials, tissue engineering, and regenerative medicine.

This chapter summarizes the current knowledge of the role of growth factors in the biology/physiology of two tissues, specifically, vascular tissue and bone. It also provides an overview of research endeavors directed at transferring and applying pertinent growth factor knowledge to biomaterials; delivery of the appropriate type, concentration, and timely sequence of bioactive growth factors, which promote interactions and functions of cells pertinent to neotissue formation, will enhance the long-term performance of implants, including tissue-engineering constructs. Future directions for research and development in these areas are outlined.


Vascular Endothelial Growth Factor Vascular Endothelial Growth Factor Level Vascular Network Blood Vessel Formation Osteoprogenitor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



absorbable collagen sponge


acidic fibroblast growth factor (equivalent to FGF-1)


activin receptor-like kinase 1


age-related macular degeneration


alkaline phosphatase


basic fibroblast growth factor (equivalent to FGF-2)


bone marrow cell


bone morphogenetic protein


extracellular matrix


US Food and Drug Administration


fibroblast growth factor


fibroblast growth factor receptor 1


fibroblast growth factor receptor 2


fibroblast growth factor-1 (equivalent to aFGF)


fibroblast growth factor-2 (equivalent to bFGF)


hematopoietic stem cell(s)


human bone-marrow stromal-cell




hypoxia-inducible factor-1α


human umbilical vein endothelial cell


insulin-like growth factor


insulin-like growth factor binding protein


matrix metalloproteinase


messenger ribonucleic acid


fms-related tyrosine kinase-1 (equivalent to VEGFR-1)


kinase insert domain receptor (equivalent to VEGFR-2)


nitric oxide


platelet-derived growth factor


platelet-derived growth factor receptor


platelet-derived growth factor receptor-α


platelet-derived growth factor receptor-β


poly (d,l-lactide)


poly(lactic acid)


poly(lactic-co-glycolic acid)


polyethylene glycol


recombinant human bone morphogenetic protein-2


severe combined immunodeficiency




transforming growth factor


transforming growth factor-β


transforming growth factor-β receptor-I


transforming growth factor-β receptor-II


vascular endothelial growth factor


vascular endothelial growth factor receptor


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringThe University of Texas at San AntonioSan AntonioUSA
  2. 2.Center for Biomedical EngineeringUniversity of KentuckyLexingtonUSA

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