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Ovarian Cancer pp 131-146 | Cite as

Epigenetics and Ovarian Cancer

  • Kenneth P. Nephew
  • Curt Balch
  • Shu Zhang
  • Tim H-M. Huang
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 149)

Cancer Epigenetics: Introduction

Epigenetics is a broad term that refers to all stably heritable alterations in gene expression that occur without changes in DNA base sequence. Epigenetic phenomena include deoxycytosine methylation, histone protein modifications, nucleosome position effects on DNA, and gene regulation by noncoding RNA molecules (Fig. 6.1); the overall epigenetic state corresponding with a specific cell phenotype is referred to as an “epigenome.” The Human Genome Project, completed in 2003, has provided a wealth of data regarding the relationship of DNA sequence to human health, and one interesting outcome of that project was the observation that humans possess far fewer genes than previously predicted. 1That vast underestimation of human genes suggested a much greater role for phenotype-specific gene regulation by other mechanisms, including epigenetic modifications. Consequently, a Human Epigenome Project, an international public/private consortium, has now been...

Keywords

Ovarian Cancer Ovarian Cancer Cell Ovarian Tumor Ovarian Cancer Cell Line H3K27 Trimethylation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors gratefully acknowledge grant support from the U.S. National Institutes of Health, National Cancer Institute grants CA085289 (to K.P.N.), CA113001 (to T. T-H. H), Ovar'coming Together (Indianapolis, IN, to C.B.), the Walther Cancer Institute (Indianapolis, IN, to K.P.N.), and Phi Beta Psi Sorority (Brownsburg, IN, to K.P.N.)

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Kenneth P. Nephew
    • 1
    • 2
  • Curt Balch
    • 1
  • Shu Zhang
    • 1
  • Tim H-M. Huang
    • 1
  1. 1.Medical SciencesIndiana UniversityBloomingtonUSA
  2. 2.Indiana University Cancer CenterIndianapolisUSA

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