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Ovarian Cancer pp 353-391 | Cite as

Animal Models of Ovarian Cancer

  • Denise C. Connolly
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 149)

Introduction

As contributors have discussed in previous chapters, our understanding of epithelial ovarian cancer (EOC) biology and clinical management of ovarian cancer patients has improved significantly over the years. Yet in spite of all of our advances, the overall improvements in patient outcomes have been incremental. The majority of patients are still diagnosed at advanced stage when the probability of disease recurrence and complications that ultimately result in death are quite high. The typical late-stage diagnosis of EOC is associated with a complex array of genetic and epigenetic alterations present in tumors. As a result, it has been difficult to determine the sequence of events that are involved in tumor initiation, progression, and maintenance. In addition, there are several morphologic variants of EOC including multiple histologic subtypes (e.g., serous, endometrioid, mucinous, clear cell, mixed Müllerian tumors) as well as tumors of low malignant potential. Most...

Keywords

Epithelial Ovarian Cancer Ovarian Tumor Ovarian Surface Epithelium Ovarian Surface Epithelium Cell Serous Epithelial Ovarian Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Fox Chase Cancer CenterPhiladelphiaUSA

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