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Ovarian Cancer pp 297-318 | Cite as

Cell Adhesion in Ovarian Cancer

  • Wafic M. ElMasri
  • Giovanna Casagrande
  • Ebony Hoskins
  • Daniel Kimm
  • Elise C. Kohn
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 149)

Introduction

Epithelial ovarian cancer is the most common cause of death among gynecologic malignancies in the Western world.1The disease presents late in more than two thirds of patients with spread in the peritoneal cavity on surfaces, intraparenchymal metastases, and in suspension in peritoneal and pleural effusions. Dissemination to and compromise of critical end organs is often the cause of patient morbidity and mortality. Methods of dissemination include the common hematogenous and lymphatic spread, but also shedding into the peritoneal cavity. It is this shedding and subsequent adherence to the serosal and organ surfaces that provides the first step in subsequent carcinomatosis and further metastasis. The advance into the peritoneal cavity, early compared with that seen with other adenocarcinomas of the pelvis and abdomen, is attributed to the ability of ovarian cancer (and fallopian tube cancers) to release tumor cells into the local environment and potential spaces of the...

Keywords

Vascular Endothelial Growth Factor Ovarian Cancer Epidermal Growth Factor Receptor Focal Adhesion Kinase Epithelial Ovarian Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Wafic M. ElMasri
    • 1
  • Giovanna Casagrande
    • 1
  • Ebony Hoskins
    • 1
  • Daniel Kimm
    • 1
  • Elise C. Kohn
    • 1
  1. 1.Medical Oncology Branch, Center for Cancer ResearchNational Cancer InstituteBethesdaUSA

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