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Ovarian Cancer pp 269-296 | Cite as

Lysophosphatidic Acid and Invasion

  • Fengqiang Wang
  • David A. Fishman
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 149)

Introduction

Lysophosphatidic acid (LPA) is a small, bioactive phospholipid produced by activated platelets, mesothelial cells, macrophage, endothelial cells, fibroblasts, adipocytes, and some cancer cells. It is involved in multiple cellular events of almost every mammalian cell type. Upon binding to G-protein–coupled receptors (GPCRs), LPA exerts a myriad of biological effects, including cell proliferation/survival, induction of neurite retraction, inhibition of gap junctional communication, and cell motility. The estimated concentrations of active, albumin-bound LPA in serum are in the range 1–5 µmol/L. Physiologic and pathophysiologic responses to LPA include wound healing, production of angiogenic factors, chemotaxis, neointima formation, tumor cell invasion, metastasis, and cell cycle progression. A large body of evidence suggests that LPA is relevant to the pathogenesis of epithelial ovarian cancer (EOC). LPA is elevated in the blood and ascites of women with ovarian cancer with...

Keywords

Vascular Endothelial Growth Factor Epithelial Ovarian Cancer Ovarian Cancer Cell Vascular Endothelial Growth Factor Expression SKOV3 Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Obstetrics Gynecology, and Reproductive Sciences, Mount Sinai School of MedicineNew York UniversityNew YorkUSA

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