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Ovarian Cancer pp 241-267 | Cite as

Lipid Generation and Signaling in Ovarian Cancer

  • Yan Xu
  • Dongmei Wang
  • Zeneng Wang
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 149)

Introduction

Remaining as one of the most deadly diseases for the past several decades, ovarian cancer will cause an estimated 15,520 deaths in the United States in 2008.1 From 1991 to 2004, the death rate of ovarian cancer has improved merely 8%.1 Lack of effective early detection, the highly metastatic nature of the disease, and lack of highly effective therapeutic treatment for the late-stage cancer are the main reasons for the low survival rate of patients with ovarian cancer.2, 3, 4

The involvement of extracellular lipid signaling molecules, lysophosphatidic acid (LPA) in particular, in ovarian cancer was first shown in 1995.5,6 Since then, numerous reports have been published demonstrating that LPA regulates almost every aspect of ovarian cancer cell biology, and LPA has been considered as an emerging and important target for ovarian cancer.7, 8, 9, 10, 11, 12, 13, 14, 15Elevated LPA levels in ascites and blood from patients with ovarian cancer have been reported and supported...

Keywords

Ovarian Cancer Ovarian Cancer Cell Phosphatidic Acid Ovarian Cancer Cell Line Epithelial Ovarian Cancer Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

We would like to acknowledge Dr. Paul Fox (The Cleveland Clinic Foundation) for letting us use his hypoxia chamber. This work was supported by NIH grants RO1 CA095042 and CA-89228 (to Y.X.).

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyIndiana UniversityIndianapolisUSA
  2. 2.Department of Cancer BiologyThe Lerner Research Institute, Cleveland ClinicClevelandUSA

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