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Application of Nitroazoles

  • L. Larina
  • V. Lopyrev
Chapter
Part of the Topics in Applied Chemistry book series (TAPP)

Abstract

The application of C- and N-nitroazoles, many of which are well-known medicines, hypoxic cell radiosensitizers, explorer materials, and important building blocks in drug discovery is described. Main attention is paid to nitroimidazole derivatives among which are medicines with a vividly expressed therapeutical activity (azomycine, metronidazole, ipronidazole, carnidazole, dimetridazole, secnidazole and many others) and also to nitrotriazoles, nitrotetrazoles, nitrobenzazoles, and polynitroazoles used as high-energy compounds. Nitrobenzazoles are often used in drug design and also in nonlinear optical materials, food additives, and energetic compounds. They also show versatile pharmacological activities, such as antifungal, antibacterial, antitumor, antihelmintic, antiallergic, antineoplactic, local analgesic, and spazmolytic.

Keywords

Hypoxic Tumor Hypoxic Cell Nonlinear Optical Material Energetic Compound High Electron Affinity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Favorsky Irkutsk Institute of ChemistryIrkutskRussian

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