Label-Free Biochemical Sensors Based on Optical Microresonators

  • Chung-Yen Chao
  • Tao Ling
  • L. Jay Guo
Part of the Integrated Analytical Systems book series (ANASYS)


Biochemical sensors play a significant role in extensive applications that have tight relationship with human life. These sensors require high sensitivity and low detection limit. In this chapter, two optical sensors that meet the requirement will be discussed: polymer microring biochemical sensors and microtube resonator sensors. Both have advantages of high sensitivity, label-free detection capability, low cost, robustness, and simple fabrication process. The former devices show high sensitivity over 70 nm per RIU and low detection limit as 250 pg mm−2, while the latter ones can push sensitivity to 600 nm per RIU. Moreover, polymer microring biochemical sensors are compact and integrable in an array on a substrate; while microtube-based sensors have built-in fluidic handling capability. These features facilitate the development of miniature and highly sensitive lab-on-a-chip sensors.


Resonant Mode Resonant Wavelength Slot Waveguide Resonance Shift Microring Resonator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors would like to thank the support by the AFOSR and a University of Michigan Life Science Institute and Fisher-Thermo Pilot grant. We would also like to thank Wayne Fung for his assistance in the microring biosensor experiment, and Dr. Michael Mayer and Sheereen Majdzarringhalamaraghy for providing the liposome and membrane protein samples used in the microtube sensor experiment.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Chung-Yen Chao
    • 1
  • Tao Ling
    • 1
  • L. Jay Guo
    • 1
  1. 1.Department of Electrical Engineering and Computer ScienceUniversity of MichiganAnn ArborUSA

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