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Label-Free Biosensing with the Optofluidic Ring Resonator

  • Ian M. White
  • Hongying Zhu
  • Jonathan D. Suter
  • Xudong Fan
Chapter
Part of the Integrated Analytical Systems book series (ANASYS)

Abstract

The optofluidic ring resonator (OFRR) is a label-free refractive index biosensing platform that uses a glass capillary as a microfluidic sample delivery mechanism with an inherently integrated optical ring resonator. The device delivers molecular detection limits on par with the top-performing commercial label-free sensing technologies while reducing cost and complexity compared with fluorescence-based biosensing techniques as well as other label-free devices. The OFRR has been shown to quantify target molecules in a sample through specific biomolecular recognition events at the surface of the capillary. Examples presented here include protein detection, DNA sequence detection, and pathogen detection. The design of the OFRR makes it well-suited for integration into a lab-on-a-chip platform that will have significant implications for the diagnosis and understanding of disease.

Keywords

Surface Plasmon Resonance Resonant Mode Capture Probe Ring Resonator Resonant Wavelength 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

This work is supported by the Wallace H. Coulter Foundation Early Career Award and the NIH (1K25 EB006011).

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Ian M. White
  • Hongying Zhu
    • 1
  • Jonathan D. Suter
    • 1
  • Xudong Fan
    • 1
  1. 1.Department of Biological EngineeringUniversity of MissouriColumbiaUSA

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