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Animal Models in Cardiovascular Research pp 219–229Cite as

Iatrogenic Models of Ischemic Heart Disease

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Abstract

Ischemic heart disease is the most common cause of heart failure in humans. Ventricular dilation, hypertrophy, biochemical alterations, and edema formation are all consequences of the poor pumping capacity of the damaged myocardium. Two very different types of ischemia are studied. Global ischemia is associated with cardiac arrest usually iatrogenic during cardiopulmonary bypass surgery or from ventricular fibrillation although during the initial period of fibrillation coronary flow increases. Regional ischemia is associated with a localized myocardial infarction. The two types of ischemia differ significantly in their biochemical and electrophysiological characteristics.1

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  1. Department of Veterinary Biosciences, University of Illinois, Urbana Champaign College of Veterinary Medicine, 2001 S. Lincoln Ave., Urbana, IL, 61802, USA

    David R. Gross (Professor Emeritus)

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Gross, D.R. (2009). Iatrogenic Models of Ischemic Heart Disease. In: Animal Models in Cardiovascular Research. Springer, New York, NY. https://doi.org/10.1007/978-0-387-95962-7_9

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