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Iatrogenic, Congenic, and Transgenic Models of Hypertension

  • David R. Gross
Chapter

Abstract

Human essential hypertension is a multifactorial and complex disease involving several genes that have, thus far, defied complete characterization. Congenic models such as the spontaneously hypertensive stroke-prone rats are genetically homogeneous and thus aid the search for causative genes. The identification of quantitative trait loci (QTL) responsible for blood pressure regulation by genome-wide scanning is most commonly employed;1 however, the identification of a QTL is just the first step to identify the gene(s) of interest. Congenic strains must be produced to verify the QTL and identify the chromosomal region that must then be reduced to an appropriate size for positional cloning of the gene(s). So-called “speed congenic strategies” have been used to confirm blood pressure QTLs on rat chromosome 2.2

The number of articles published each year suggests that the various animal models of hypertension are probably the most used in cardiovascular research. The volume of significant, i.e., leading to effective treatment of the human condition, research conducted using these models verifies their importance.

Keywords

Cardiac Hypertrophy Atrial Natriuretic Peptide Renovascular Hypertension Congenic Strain Brown Norway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • David R. Gross
    • 1
  1. 1.Department of Veterinary BiosciencesUniversity of Illinois, Urbana Champaign College of Veterinary MedicineUrbanaUSA

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