Self-Assembly of Short Aromatic Peptides: From Amyloid Fibril Formation to Nanotechnology

  • Ehud GazitEmail author


Molecular self-assembly offers unique directions for the fabrication of novel supramolecular structures and advance materials. The inspiration for the development of such structures is often derived from self-assembling modules in biology, as natural systems form complex structures from simple building blocks such as amino acids, nucleic acids, and lipids. Self-assembled peptide nanostructures are assumed to serve as key building blocks in future nanotechnological devices and assemblies. These peptide structures offer the advantage of high biological systems specificity while allowing numerous chemical modifications. Short peptides self-assemble into various forms in the nano-scale, including tapes, fibrils, tubes, and spheres. Yet, the inherent thermal and chemical instability of many protein structures raise a question regarding the compatibility of peptide structure with common lithographic techniques and the long-term durability of such devices.


Amyloid Fibril Peptide Structure Simple Building Block Atomic Force Microscopy Indentation Ultrastructural Property 
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  1. 1.
    Reches, M.; Porat, Y.; and Gazit, E.: Amyloid fibrils formation by pentapeptide and tetrapeptide fragments of human calcitonin. J. Biol. Chem. 277, 35475 (2002)CrossRefGoogle Scholar
  2. 2.
    Reches, M. and Gazit, E.: Casting metal nanowires within discrete self-assembled peptide nanotubes. Science 300, 625 (2003)CrossRefGoogle Scholar
  3. 3.
    Song, Y.; Challa, S. R.; Medforth, C. J.; Qiu, Y.; Watt, R. K.; Peña, D.; Miller, J. E.; van Swol, F.; and Shelnutt, J. A.: Synthesis of Peptide-nanotube Platinum-nanoparticle Composites, Chem. Commun. 9, 1044 (2004)Google Scholar
  4. 4.
    Kol, N., et al.: Self-assembled peptide nanotubes are uniquely rigid bioinspired supramolecular structures. Nano Lett. 5, 1343 (2005)CrossRefGoogle Scholar
  5. 5.
    Adler-Abramovich, L.; Reches, M.; Sedman, V. L.; Allen, S.; Tendler, S. J. B.; and Gazit, E.: Thermal and chemical stability of diphenylalanine peptide nanotubes: implications for nanotechnological applications. Langmuir 22, 1313 (2006)CrossRefGoogle Scholar
  6. 6.
    Carny, O.; Shalev, D.; and Gazit, E.: Fabrication of coaxial metal nanowires using self-assembled peptide nanotube scaffold. Nano Lett. (2006)Google Scholar
  7. 7.
    Yemini, M.; Reches, M.; Rishpon, J.; and Gazit, E.: Novel electrochemical biosensing platform using self-assembled peptide nanotubes. Nano Lett. 5, 183 (2005)CrossRefGoogle Scholar
  8. 8.
    Yemini, M.; Reches, M.; Gazit, E.; and Rishpon, J.: Peptide nanotubes modified electrodes for enzyme-biosensors applications. Anal. Chem. 77, 5155 (2005)CrossRefGoogle Scholar
  9. 9.
    Reches, M. and Gazit, E.: Formation of closed-cage nanostructures by self-assembly of aromatic dipeptides. Nano Lett. 4, 581 (2004)CrossRefGoogle Scholar
  10. 10.
    Margulis, L.; Salitra, G.; Tenne, R.; and Talianker, M.: Nested fullerene-like structures. Nature 365, 113 (1993)CrossRefGoogle Scholar
  11. 11.
    Reches, M. and Gazit, E.: Designed aromatic homo-dipeptides: Formation of ordered nanostructures and potential nanotechnological applications. Phys. Biol. 3, S10 (2006)CrossRefGoogle Scholar
  12. 12.
    Reches, M. and Gazit, E.: Self-assembly of peptide nanotubes and amyloid-like structures by charged-termini capped diphenylalanine peptide analogues. Israel J. Chem. 45, 363 (2005)CrossRefGoogle Scholar
  13. 13.
    Mahler, A.; Reches, M.; Rechter, M.; Cohen, S.; and Gazit, E.: Rigid, self-assembled hydrogel composed of a modified aromatic dipeptide. Adv. Mater. 18, 1365–1370 (2006)CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Molecular Microbiology and Biotechnology Life Sciences facultyTel Aviv UniversityTel AvivIsrael

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