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COP-Mediated Vesicle Transport

  • Silvere Pagant
  • Elizabeth Miller
Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

Transport of lipid and protein within the early secretory pathway is mediated by small transport vesicles that act as molecular taxis, shuttling cargoes between the endoplasmic reticulum (ER) and Golgi apparatus and within the Golgi. These vesicles are sculpted from donor organelles by distinct sets of cytoplasmic coat proteins that deform the lipid bilayer into a highly curved structure while selecting specific cargo proteins for efficient delivery to the acceptor organelle. The COPII coat generates vesicles from the ER membrane that transport newly synthesized proteins to the Golgi, whereas the COPI coat creates vesicles that mediate both retrograde Golgi-to-ER and intra-Golgi trafficking. These distinct cytoplasmic coats represent the minimal machinery required for vesicle formation and share some common mechanisms to drive intracellular protein transport. This chapter highlights the molecular details of COPII- and COPI-mediated vesicular traffic.

Keywords

Guanine Nucleotide Exchange Factor Cargo Protein Amphipathic Helix Coat Component COPII Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  1. 1.Department of Biological SciencesColumbia UniversityNew YorkUSA

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