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Trafficking Inside Cells pp 67–83Cite as

The Endocytic Pathway

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Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

As the interface between the intracellular and extracellular environments, the plasma membrane forms a barrier to the uptake of nutrients and other macromolecules as well as a defense against pathogens. Specialized endocytic mechanisms direct the internalization of plasma membrane components, together with extracellular fluid, into vesicles that bud into the cytoplasm and deliver their contents to endosomes. Endosomal sorting processes lead to the delivery of some internalized molecules to the lysosome for degradation, while others are recycled back to the cell surface or routed to other intracellular compartments, including those of the secretory pathway. Here, we summarize the main mechanisms of internalization, describe the endocytic compartments and the pathways that connect them, and examine the processes that direct sorting along these different pathways.

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  1. Centre for Molecular Medicine and Therapeutics, University of British Columbia, 980 W 28th Ave, Vancouver, BC, V5Z 4H4, Canada

    Elizabeth Conibear

  2. Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

    Yuen Yi C. Tam

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Conibear, E., Tam, Y.Y.C. (2009). The Endocytic Pathway. In: Trafficking Inside Cells. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-93877-6_4

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