The Exocytic Pathway and Development

  • Hans Schotman
  • Catherine Rabouille
Part of the Molecular Biology Intelligence Unit book series (MBIU)


The development of a multicellular organism is mosdy controlled at the transcriptional level but it has also been shown to require the transport of membrane and proteins through the exocytic pathway to the plasma membrane and the extracellular medium. As they are transported in the different compartments making up this pathway, newly synthesized proteins are modified and dispatched to their final destinations. In this chapter, we will first outline how mutations in genes encoding key proteins of this pathway, such as components of the COPII coat, tethers, components of the SNARE machinery, glycosylation enzymes, etc, lead to severe developmental defects. In the second part, we will describe how specific steps of epithelial development, such as epithelial cell formation, establishment of polarity, junction formation and morphogen secretion, are controlled or regulated by the exocytic machinery.


MDCK Cell Adherens Junction Septate Junction COPII Vesicle Exocyst Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  1. 1.Cell Microscopy Centre Department of Cell Biology and Institute of BiomembraneUniversity Medical CenterUtrechtThe Netherlands

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