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The Exocytic Pathway and Development

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Book cover Trafficking Inside Cells

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

The development of a multicellular organism is mosdy controlled at the transcriptional level but it has also been shown to require the transport of membrane and proteins through the exocytic pathway to the plasma membrane and the extracellular medium. As they are transported in the different compartments making up this pathway, newly synthesized proteins are modified and dispatched to their final destinations. In this chapter, we will first outline how mutations in genes encoding key proteins of this pathway, such as components of the COPII coat, tethers, components of the SNARE machinery, glycosylation enzymes, etc, lead to severe developmental defects. In the second part, we will describe how specific steps of epithelial development, such as epithelial cell formation, establishment of polarity, junction formation and morphogen secretion, are controlled or regulated by the exocytic machinery.

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  1. Cell Microscopy Centre Department of Cell Biology and Institute of Biomembrane, University Medical Center, Utrecht, The Netherlands

    Hans Schotman & Catherine Rabouille

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Schotman, H., Rabouille, C. (2009). The Exocytic Pathway and Development. In: Trafficking Inside Cells. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-93877-6_20

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