Posttranslational Control of Protein Trafficking in the Post-Golgi Secretory and Endocytic Pathway

  • Robert Piper
  • Nia Bryant
Part of the Molecular Biology Intelligence Unit book series (MBIU)


Membrane proteins are sorted throughout the secretory and endocytic pathway by cis-acting sorting motifs that are recognized in trans by a host of protein machinery. While sorting information for some proteins can be an intrinsic nonregulated property embedded within their primary sequence, sorting information for other proteins can be revealed, concealed or appended by posttranslational modification. In addition, the machinery that decodes sorting signals can be regulated by posttranslational modification. This chapter will highlight how membrane traffic through the late-secretory and endocytic pathway is controlled by the phosphorylation and ubiquitination of both cargo and the protein sorting machinery.


Early Endosome Endocytic Pathway Protein Sorting Cargo Protein Sorting Signal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  1. 1.Physiology and BiophysicsUniversity of IowaIowa CityUSA
  2. 2.Department of Biochemistry and Cell BiologyUniversity of GlasgowGlasgowUK

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