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Regulation and Coordination of Intracellular Trafficking: An Overview

  • Julie Donaldson
  • Nava Segev
Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

During the last two decades, efforts in the protein trafficking field have focused primarily on the identification of the machinery components of vesicular transport and mechanisms that underlie it. In addition, research has started to reveal how intracellular trafficking is regulated. Here, we summarize the current state of our knowledge about the regulation of vesicular transport and its coordination with other cellular processes. At the most basic level, individual transport steps are regulated spatially and temporally in two different ways. First, molecular switches of the Arf, Rab and Rho GTPase families regulate the assembly of components of the vesicular transport machinery on membranes, mediating the formation, targeting and fusion of vesicles that shutde cargo between intracellular compartments. Second, reversible posttranslational modifications, like phosphorylation and ubiquitination, allow efficient cargo sorting and machinery component recycling. At a higher level, individual transport steps are integrated into whole pathways, with GTPases as a mechanism for this integration. Finally, intracellular trafficking pathways are coordinated with other cellular processes. Here too, GTPases appear to play a role by orchestrating coordination.

Keywords

Intracellular Trafficking Vesicular Transport Endocytic Pathway Donor Compartment Transport Step 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  1. 1.Department of Biological SciencesUniversity of Illinois at ChicagoChicagoUSA
  2. 2.Laboratory of Cell Biology NHLBINational Institutes of HealthBethesdaUSA

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