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Trafficking Inside Cells pp 329–341Cite as

Regulation and Coordination of Intracellular Trafficking: An Overview

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Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

During the last two decades, efforts in the protein trafficking field have focused primarily on the identification of the machinery components of vesicular transport and mechanisms that underlie it. In addition, research has started to reveal how intracellular trafficking is regulated. Here, we summarize the current state of our knowledge about the regulation of vesicular transport and its coordination with other cellular processes. At the most basic level, individual transport steps are regulated spatially and temporally in two different ways. First, molecular switches of the Arf, Rab and Rho GTPase families regulate the assembly of components of the vesicular transport machinery on membranes, mediating the formation, targeting and fusion of vesicles that shutde cargo between intracellular compartments. Second, reversible posttranslational modifications, like phosphorylation and ubiquitination, allow efficient cargo sorting and machinery component recycling. At a higher level, individual transport steps are integrated into whole pathways, with GTPases as a mechanism for this integration. Finally, intracellular trafficking pathways are coordinated with other cellular processes. Here too, GTPases appear to play a role by orchestrating coordination.

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Authors and Affiliations

  1. Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, 60607, USA

    Nava Segev

  2. Laboratory of Cell Biology NHLBI, National Institutes of Health, Bethesda, Maryland, USA

    Julie Donaldson PhD

Authors
  1. Julie Donaldson PhD
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  2. Nava Segev
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Correspondence to Nava Segev .

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© 2009 Landes Bioscience and Springer Science+Business Media

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Donaldson, J., Segev, N. (2009). Regulation and Coordination of Intracellular Trafficking: An Overview. In: Trafficking Inside Cells. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-93877-6_15

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