Advertisement

Lipid-Dependent Membrane Remodelling in Protein Trafficking

  • Priya P. Chandra
  • Nicholas T. Ktistakis
Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

Trafficking pathways of eukaryotic cells exhibit sophisticated interplay between protein and lipid components. The protein molecules and their interacting networks are fairly well characterised. However, the lipid components and their regulation are much less understood. In this chapter, we describe our current understanding of how lipid dynamics can contribute to intracellular trafficking, based on evidence from genetic, biochemical and structural studies. We discuss issues concerning lipid heterogeneity and interconvertibility, and provide examples of how specific lipids can enable membrane remodelling in various transport steps.

Keywords

Coat Protein Phosphatidic Acid Phosphatidic Acid Lipid Species Protein Trafficking 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Parton RG, Simons K. The multiple faces of caveolae. Nat Rev Mol Cell Biol 2007; 8:185–94.PubMedGoogle Scholar
  2. 2.
    Munro S. Lipid rafts: Elusive or illusive? Cell 2003; 115:377–88.PubMedGoogle Scholar
  3. 3.
    Shaw AS. Lipid rafts: Now you see them, now you don’t. Nat Immunol 2006; 7:1139–42.PubMedGoogle Scholar
  4. 4.
    Jacobson K, Mouritsen OG, Anderson RG. Lipid rafts: At a crossroad between cell biology and physics. Nat Cell Biol 2007; 9:7–14.PubMedGoogle Scholar
  5. 5.
    Palade G. Intracellular aspects of the process of protein synthesis. Science 1975; 189:347–58.Google Scholar
  6. 6.
    Rothman JE. Lasker basic medical research award: The machinery and principles of vesicle transport in the cell. Nat Med 2002; 8:1059–62.PubMedGoogle Scholar
  7. 7.
    Schekman R. Lasker basic medical research award: SEC mutants and the secretory apparatus. Nat Med 2002; 8:1055–8.PubMedGoogle Scholar
  8. 8.
    Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science 1986; 232:34–47.PubMedGoogle Scholar
  9. 9.
    Slepnev VI, De Camilli P. Accessory factors in clathrin-dependent synaptic vesicle endocytosis. Nat Rev Neurosci 2000; 1:161–72.PubMedGoogle Scholar
  10. 10.
    Conner SD, Schmid SL. Regulated portals of entry into the cell. Nature 2003; 422:37–44.PubMedGoogle Scholar
  11. 11.
    Harrison SC, Kirchhausen T. Clathrin, cages, and coated vesicles. Cell 1983; 33:650–2.PubMedGoogle Scholar
  12. 12.
    Nichols BJ, Lippincott-Schwartz J. Endocytosis without clathrin coats. Trends Cell Biol 2001; 11:406–12.PubMedGoogle Scholar
  13. 13.
    Gruenberg J. The endocytic pathway: A mosaic of domains. Nat Rev Mol Cell Biol 2001; 2:721–30.PubMedGoogle Scholar
  14. 14.
    Traub LM, Kornfeld S. The trans-Golgi network: A late secretory sorting station. Curr Opin Cell Biol 1997; 9:527–33.PubMedGoogle Scholar
  15. 15.
    Kirchhausen T. Three ways to make a vesicle. Nat Rev Mol Cell Biol 2000; 1:187–98.PubMedGoogle Scholar
  16. 16.
    Lee MC, Miller EA, Goldberg J et al. Bi-directional protein transport between the ER and Golgi. Annu Rev Cell Dev Biol 2004; 20:87–123.PubMedGoogle Scholar
  17. 17.
    Schekman R, Mellman I. Does COPI go both ways? Cell 1997; 90:197–200.PubMedGoogle Scholar
  18. 18.
    Donaldson JG, Lippincott-Schwartz J. Sorting and signaling at the Golgi complex. Cell 2000; 101: 693–6.PubMedGoogle Scholar
  19. 19.
    Harsay E, Schekman R. Avl9p, a member of a novel protein superfamily, functions in the late secretory pathway. Mol Biol Cell 2007; 18:1203–19.PubMedGoogle Scholar
  20. 20.
    Ikonen E, Simons K. Protein and lipid sorting from the trans-Golgi network to the plasma membrane in polarized cells. Semin Cell Dev Biol 1998; 9:503–9.PubMedGoogle Scholar
  21. 21.
    Holthuis JC, Levine T P. Lipid traffic: Floppy drives and a superhighway. Nat Rev Mol Cell Biol 2005; 6:209–20.PubMedGoogle Scholar
  22. 22.
    Sprong H, van der Sluijs P, van Meer G. How proteins move lipids and lipids move proteins. Nat Rev Mol Cell Biol 2001; 2:504–13.PubMedGoogle Scholar
  23. 23.
    Athenstaedt K, Daum G. Phosphatidic acid, a key intermediate in lipid metabolism. Eur J Biochem 1999; 266:1–16.PubMedGoogle Scholar
  24. 24.
    Presley JF, Cole NB, Schroer TA et al. ER-to-Golgi transport visualized in living cells. Nature 1997; 389:81–5.PubMedGoogle Scholar
  25. 25.
    Presley JF, Ward TH, Pfeifer AC et al. Dissection of COPI and Arfl dynamics in vivo and role in Golgi membrane transport. Nature 2002; 417:187–93.PubMedGoogle Scholar
  26. 26.
    Bonifacino JS, Lippincott-Schwartz J. Coat proteins: Shaping membrane transport. Nat Rev Mol Cell Biol 2003; 4:409–14.PubMedGoogle Scholar
  27. 27.
    McMahon HT, Mills IG. COP and clathrin-coated vesicle budding: Different pathways, common approaches. Curr Opin Cell Biol 2004; 16:379–91.PubMedGoogle Scholar
  28. 28.
    Pryer NK, Wuestehube LJ, Schekman R. Vesicle-mediated protein sorting. Annu Rev Biochem 1992; 61:471–516.PubMedGoogle Scholar
  29. 29.
    Schekman R, Orci L. Coat proteins and vesicle budding. Science 1996; 271:1526–33.PubMedGoogle Scholar
  30. 30.
    Springer S, Spang A, Schekman R. A primer on vesicle budding. Cell 1999; 97:145–8.PubMedGoogle Scholar
  31. 31.
    Barlowe C et al. COPII: A membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum. Cell 1994; 77:895–907.PubMedGoogle Scholar
  32. 32.
    Waters MG, Serafini T, Rothman JE. ‘Coatomer’: A cytosolic protein complex containing subunits of nonclathrin-coated Golgi transport vesicles. Nature 1991; 349:248–51.PubMedGoogle Scholar
  33. 33.
    Pearse BM. Coated vesicles from pig brain: Purification and biochemical characterization. J Mol Biol 1975; 97:93–8.PubMedGoogle Scholar
  34. 34.
    Donaldson JG, Cassel D, Kahn RA et al. ADP-ribosylation factor, a small GTP-binding protein, is required for binding of the coatomer protein beta-COP to Golgi membranes. Proc Natl Acad Sci USA 1992; 89:6408–12.PubMedGoogle Scholar
  35. 35.
    Orel L, Palmer DJ, Amherdt M et al. Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol. Nature 1993; 364:732–4.Google Scholar
  36. 36.
    Zhu Y, Drake MT, Kornfeld S. ADP-ribosylation factor 1 dependent clathrin-coat assembly on synthetic liposomes. Proc Natl Acad Sci USA 1999; 96:5013–8.PubMedGoogle Scholar
  37. 37.
    Bonifacino JS. The GGA proteins: Adaptors on the move. Nat Rev Mol Cell Biol 2004; 5:23–32.PubMedGoogle Scholar
  38. 38.
    Paleotti O, Macia E, Luton F et al. The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes. J Biol Chem 2005; 280:21661–6.PubMedGoogle Scholar
  39. 39.
    Bi X, Corpina RA, Goldberg J. Structure of the Sec23/24-Sarl prebudding complex of the COPII vesicle coat. Nature 2002; 419:271–7.PubMedGoogle Scholar
  40. 40.
    Goldberg J. Decoding of sorting signals by coatomer through a GTPase switch in the COPI coat complex. Cell 2000; 100:671–9.PubMedGoogle Scholar
  41. 41.
    Musacchio A, Smith CJ, Roseman AM et al. Functional organization of clathrin in coats: Combining electron cryomicroscopy and X-ray crystallography. Mol Cell 1999; 3:761–70.PubMedGoogle Scholar
  42. 42.
    ter Haar E, Musacchio A, Harrison SC et al. Atomic structure of clathrin: A beta propeller terminal domain joins an alpha zigzag linker. Cell 1998; 95:563–73.PubMedGoogle Scholar
  43. 43.
    Matsuoka K, Orci L, Amherdt M et al. COPII-coated vesicle formation reconstituted with purified coat proteins and chemically defined liposomes. Cell 1998; 93:263–75.PubMedGoogle Scholar
  44. 44.
    Smith CJ, Grigorieff N, Pearse BM. Clathrin coats at 21 A resolution: A cellular assembly designed to recycle multiple membrane receptors. EMBO J 1998; 17:4943–53.PubMedGoogle Scholar
  45. 45.
    Alb Jr JG, Kearns MA, Bankaitis VA. Phospholipid metabolism and membrane dynamics. Curr Opin Cell Biol 1996; 8:534–41.PubMedGoogle Scholar
  46. 46.
    Chernomordik LV, Kozlov MM. Protein-lipid interplay in fusion and fission of biological membranes. Annu Rev Biochem 2003; 72:175–207.PubMedGoogle Scholar
  47. 47.
    van Meer G, Sprong H. Membrane lipids and vesicular traffic. Curr Opin Cell Biol 2004; 16:373–8.PubMedGoogle Scholar
  48. 48.
    Rodal SK, Skretting G, Garred O et al. Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol Biol Cell 1999; 10:961–74.PubMedGoogle Scholar
  49. 49.
    Subtil A, Gaidarov I, Kobylarz K et al. Acute cholesterol depletion inhibits clathrin-coated pit budding. Proc Natl Acad Sci USA 1999; 96:6775–80.PubMedGoogle Scholar
  50. 50.
    Hodgkin MN, Pettitt TR, Martin A et al. Diacylglycerols and phosphatidates: Which molecular species are intracellular messengers. TIBS 1998; 23:200–4.PubMedGoogle Scholar
  51. 51.
    Berridge MJ, Irvine RF. Inositol phosphates and cell signalling. Nature 1989; 341:197–205.PubMedGoogle Scholar
  52. 52.
    Czech MP. PIP2 and PIP3: Complex roles at the cell surface. Cell 2000; 100:603–6.PubMedGoogle Scholar
  53. 53.
    van Blitterswijk WJ, van der Luit AH, Veldman RJ et al. Ceramide: Second messenger or modulator of membrane structure and dynamics? Biochem J 2003; 369:199–211.PubMedGoogle Scholar
  54. 54.
    Chang YY, Kennedy EP. Biosynthesis of phosphatidyl glycerophosphate in Escherichia coli. J Lipid Res 1967; 8:447–55.PubMedGoogle Scholar
  55. 55.
    Majerus PW, Connolly TM, Deckmyn H et al. The metabolism of phosphoinositide-derived messenger molecules. Science 1986; 234:1519–26.PubMedGoogle Scholar
  56. 56.
    Tolias KF, Cantley LC. Pathways for phosphoinositide synthesis. Chem Phys Lipids 1999; 98:69–77.PubMedGoogle Scholar
  57. 57.
    Huitema K, van den Dikkenberg J, Brouwers JF et al. Identification of a family of animal sphingomyelin synthases. EMBO J 2004; 23:33–44.PubMedGoogle Scholar
  58. 58.
    Voelker DR, Kennedy EP. Cellular and enzymic synthesis of sphingomyelin. Biochemistry 1982; 21:2753–9.PubMedGoogle Scholar
  59. 59.
    Brown HA, Gutowski S, Moomaw CR et al. ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity. Cell 1993; 75:1137–44.PubMedGoogle Scholar
  60. 60.
    Jenkins G, Fisette P, Anderson R. Type I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid. J Biol Chem 1994; 269:11547–54.PubMedGoogle Scholar
  61. 61.
    Moritz A, De Graan PN, Gispen WH et al. Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase. J Biol Chem 1992; 267:7207–10.PubMedGoogle Scholar
  62. 62.
    Bankaitis VA, Aitken JR, Cleves AE et al. An essential role for a phospholipid transfer protein in yeast Golgi function. Nature 1990; 347:561–2.PubMedGoogle Scholar
  63. 63.
    Cleves AE, McGee TP, Whitters EA et al. Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein. Cell 1991; 64:789–800.PubMedGoogle Scholar
  64. 64.
    Kearns BG, McGee TP, Mayinger P et al. Essential role for diacylglycerol in protein transport from the yeast Golgi complex. Nature 1997; 387:101–5.PubMedGoogle Scholar
  65. 65.
    Patton-Vogt JL et al. Role of the yeast phosphatidylinositol/phosphatidylcholine transfer protein (Secl4p) in phosphatidylcholine turnover and INOl regulation. J Biol Chem 1997; 272:20873–83.Google Scholar
  66. 66.
    Xie Z, Fang M, Rivas MP et al. Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects. Proc Natl Acad Sci USA 1998; 95:12346–51.PubMedGoogle Scholar
  67. 67.
    Hama H, Schnieders EA, Thorner J et al. Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae. J Biol Chem 1999; 274:34294–300.PubMedGoogle Scholar
  68. 68.
    Schu PV, Takegawa K, Fry MJ et al. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science 1993; 260:88–91.PubMedGoogle Scholar
  69. 69.
    Walch-Solimena C, Novick P. The yeast phosphatidylinositol-4-OH kinase pikl regulates secretion at the Golgi. Nature Cell Biol 1999; 1:523–5.PubMedGoogle Scholar
  70. 70.
    Odorizzi G, Babst M, Emr SD. Fablp PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body. Cell 1998; 95:847–58.PubMedGoogle Scholar
  71. 71.
    Wang YJ, Wang J, Sun HQ et al. Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. Cell 2003; 114:299–310.PubMedGoogle Scholar
  72. 72.
    Litvak V, Dahan N, Ramachandran S et al. Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function. Nat Cell Biol 2005; 7:225–34.PubMedGoogle Scholar
  73. 73.
    Spang A, Matsuoka K, Hamamoto S et al. Coatomer, Arflp, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes. Proc Natl Acad Sci USA 1998; 95:11199–204.PubMedGoogle Scholar
  74. 74.
    Takei K, Haucke V, Slepnev V et al. Generation of coated intermediates of clathrin-mediated endocytosis on protein-free liposomes. Cell 1998; 94:131–41.PubMedGoogle Scholar
  75. 75.
    Lemmon MA. Phosphoinositide recognition domains. Traffic 2003; 4:201–13.PubMedGoogle Scholar
  76. 76.
    Roth MG. Phosphoinositides in constitutive membrane traffic. Physiol Rev 2004; 84:699–730.PubMedGoogle Scholar
  77. 77.
    Manifava M, Thuring JW, Lim ZY et al. Differential binding of traffic-related proteins to phosphatidic acid-or phosphatidylinositol (4,5)-bisphosphate-coupled affinity reagents. J Biol Chem 2001; 276:8987–94.PubMedGoogle Scholar
  78. 78.
    Gaidarov I, Chen Q, Falck JR et al. A functional phosphatidylinositol 3,4,5-trisphosphate/ phosphoinositide binding domain in the clathrin adaptor AP-2 alpha subunit. Implications for the endocytic pathway. J Biol Chem 1996; 271:20922–9.PubMedGoogle Scholar
  79. 79.
    Gaidarov I, Keen JH. Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits. J Cell Biol 1999; 146:755–64.PubMedGoogle Scholar
  80. 80.
    Honing S, Ricotta D, Krauss M et al. Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2. Mol Cell 2005; 18:519–31.PubMedGoogle Scholar
  81. 81.
    Papayannopoulos V, Co C, Prehoda KE et al. A polybasic motif allows N-WASP to act as a sensor of PIP(2) density. Mol Cell 2005; 17:181–91.PubMedGoogle Scholar
  82. 82.
    Roth MG. Lipid regulators of membrane traffic through the Golgi complex. Trends Cell Biol 1999; 9:174–9.PubMedGoogle Scholar
  83. 83.
    Roth MG, Sternweis PC. The role of lipid signaling in constitutive membrane traffic. Curr Opin Cell Biol 1997; 9:519–26.PubMedGoogle Scholar
  84. 84.
    Antonny B, Huber I, Paris S et al. Activation of ADP-ribosylation factor 1 GTPase-activating protein by phosphatidylcholine-derived diacylglycerols. J Biol Chem 1997; 272:30848–51.PubMedGoogle Scholar
  85. 85.
    Bigay J, Gounon P, Robineau S et al. Lipid packing sensed by ArfGAPl couples COPI coat disas-sembly to membrane bilayer curvature. Nature 2003; 426:563–6.PubMedGoogle Scholar
  86. 86.
    Rosenthal JA, Chen H, Slepnev VI et al. The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module. J Biol Chem 1999; 274:33959–65.PubMedGoogle Scholar
  87. 87.
    Ford MG, Mills IG, Peter BJ et al. Curvature of clathrin-coated pits driven by epsin. Nature 2002; 419:361–6.PubMedGoogle Scholar
  88. 88.
    Ford MG, Pearse BM, Higgins MK et al. Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes. Science 2001; 291:1051–5.PubMedGoogle Scholar
  89. 89.
    Habermann B. The BAR-domain family of proteins: A case of bending and binding? EMBO Rep 2004; 5:250–5.PubMedGoogle Scholar
  90. 90.
    Lee MC, Schekman R. Cell biology: BAR domains go on a bender. Science 2004; 303:479–80.PubMedGoogle Scholar
  91. 91.
    Peter BJ, Kent HM, Mills IG et al. BAR domains as sensors of membrane curvature: The amphiphysin BAR structure. Science 2004; 303:495–9.PubMedGoogle Scholar
  92. 92.
    Carlton J, Bujny M, Peter BJ et al. Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high-curvature membranes and 3-phosphoinositides. Curr Biol 2004; 14:1791–800.PubMedGoogle Scholar
  93. 93.
    Baumgart T, Hess ST, Webb WW. Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension. Nature 2003; 425:821–4.PubMedGoogle Scholar
  94. 94.
    Roux A, Cuvelier D, Nassoy P et al. Role of curvature and phase transition in lipid sorting and fission of membrane tubules. EMBO J 2005, (sj.emboj.7600631).Google Scholar
  95. 95.
    Brügger B, Sandhoff R, Wegehingel S et al. Evidence for segregation of sphingomyelin and choles-terol during formation of COPI-coated vesicles. J Cell Biol 2000; 151:507–18.PubMedGoogle Scholar
  96. 96.
    Zha X, Pierini LM, Leopold PL et al. Sphingomyelinase treatment induces ATP-independent endocytosis. J Cell Biol 1998; 140:39–47.PubMedGoogle Scholar
  97. 97.
    Holopainen JM, Angelova MI, Kinnunen PK. Vectorial budding of vesicles by asymmetrical enzymatic formation of ceramide in giant liposomes. Biophys J 2000; 78:830–8.PubMedGoogle Scholar
  98. 98.
    Matsuo H, Chevallier J, Mayran N et al. Role of LBPA and Alix in multivesicular liposome formation and endosome organization. Science 2004; 303:531–4.PubMedGoogle Scholar
  99. 99.
    Mukherjee S, Maxfield FR. Membrane domains. Annu Rev Cell Dev Biol 2004; 20:839–66.PubMedGoogle Scholar
  100. 100.
    Pfeffer S. Membrane domains in the secretory and endocytic pathways. Cell 2003; 112:507–17.PubMedGoogle Scholar
  101. 101.
    Bankaitis VA, Morris AJ. Lipids and the exocytotic machinery of eukaryotic cells. Curr Opin Cell Biol 2003; 15:389–95.PubMedGoogle Scholar
  102. 102.
    Muniz M, Morsomme P, Riezman H. Protein sorting upon exit from the endoplasmic reticulum. Cell 2001; 104:313–20.PubMedGoogle Scholar
  103. 103.
    Motley A, Bright NA, Seaman MN et al. Clathrin-mediated endocytosis in AP-2-depleted cells. J Cell Biol 2003; 162:909–18.PubMedGoogle Scholar
  104. 104.
    Lakadamyali M, Rust MJ, Zhuang X. Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell 2006; 124:997–1009.PubMedGoogle Scholar
  105. 105.
    Blumental-Perry A, Haney CJ, Weixel KM et al. Phosphatidylinositol 4-phosphate formation at ER exit sites regulates ER export. Dev Cell 2006; 11:671–82.PubMedGoogle Scholar
  106. 106.
    Fabbri M, Bannykh S, Balch W. Export of protein from the endoplasmic reticulum is regulated by a diacylglycerol/phorbol ester binding protein. J Biol Chem 1994; 269:26848–57.PubMedGoogle Scholar
  107. 107.
    Nagaya H, Wada I, Jia YJ et al. Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domains. Mol Biol Cell 2002; 13:302–16.PubMedGoogle Scholar
  108. 108.
    Pathre P, Shome K, Blumental-Perry A et al. Activation of phospholipase D by the small GTPase Sarlp is required to support COPII assembly and ER export. EMBO J 2003; 22:4059–69.PubMedGoogle Scholar
  109. 109.
    Runz H, Miura K, Weiss M et al. Sterols regulate ER-export dynamics of secretory cargo protein ts-045-G. EMBO J 2006; 25:2953–65.PubMedGoogle Scholar
  110. 110.
    Shimoi W, Ezawa I, Nakamoto K et al. pi25 is localized in endoplasmic reticulum exit sites and involved in their organization. J Biol Chem 2005; 280:10141–8.PubMedGoogle Scholar
  111. 111.
    Gruenberg J. Lipids in endocytic membrane transport and sorting. Curr Opin Cell Biol 2003; 15:382–8.PubMedGoogle Scholar
  112. 112.
    Martin TF. Phosphoinositides as spatial regulators of membrane traffic. Curr Opin Neurobiol 1997; 7:331–8.PubMedGoogle Scholar
  113. 113.
    Forrester JS, Milne SB, Ivanova PT et al. Computational lipidomics: A multiplexed analysis of dynamic changes in membrane lipid composition during signal transduction. Mol Pharmacol 2004; 65:813–21.PubMedGoogle Scholar
  114. 114.
    Han X, Gross RW. Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: A bridge to lipidomics. J Lipid Res 2003; 44:1071–9.PubMedGoogle Scholar
  115. 115.
    Han X, Gross RW. Shotgun lipidomics: Electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples. Mass Spectrom Rev 2005; 24:367–412.PubMedGoogle Scholar
  116. 116.
    Liu W, Lippincott-Schwartz J. Illuminating COPII coat dynamics. Nat Struct Mol Biol 2005; 12:106–7.PubMedGoogle Scholar
  117. 117.
    Sato K, Nakano A. Dissection of COPII subunit-cargo assembly and disassembly kinetics during Sarlp-GTP hydrolysis. Nat Struct Mol Biol 2005; 12:167–74.PubMedGoogle Scholar
  118. 118.
    Yeung T, Barlowe C, Schekman R. Uncoupled packaging of targeting and cargo molecules during transport vesicle budding from the endoplasmic reticulum. J Biol Chem 1995; 270:30567–70.PubMedGoogle Scholar
  119. 119.
    Barlowe C, Schekman R. SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER. Nature 1993; 365:347–9.PubMedGoogle Scholar
  120. 120.
    Lee MC, Orci L, Hamamoto S et al. Sarlp N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle. Cell 2005; 122:605–17.PubMedGoogle Scholar
  121. 121.
    Randazzo PA, Nie Z, Miura K et al. Molecular aspects of the cellular activities of ADP-ribosylation factors. Sci STKE 2002; 59.Google Scholar
  122. 122.
    Kahn RA, Kern FG, Clark J et al. Human ADP-ribosylation factors: A functionally conserved family of GTP-binding proteins. Journal of Biological Chemistry 1991; 266:2606–14.PubMedGoogle Scholar
  123. 123.
    Seidel Illrd RD, Amor JC, Kahn RA et al. Structural perturbations in human ADP ribosylation factor-1 accompanying the binding of phosphatidylinositides. Biochemistry 2004; 43:15393–403.PubMedGoogle Scholar
  124. 124.
    Aoe T, Cukierman E, Lee A et al. The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase-activating protein for ARF1. EMBO J 1997; 16:7305–16.PubMedGoogle Scholar
  125. 125.
    Lee SY, Yang JS, Hong W et al. ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation. J Cell Biol 2005; 168:281–90.PubMedGoogle Scholar
  126. 126.
    Yang JS, Lee SY, Gao M et al. ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat. J Cell Biol 2002; 159:69–78.PubMedGoogle Scholar
  127. 127.
    Yanagisawa LL, Marchena J, Xie Z et al. Activity of specific lipid-regulated ADP ribosylation factor-GTPase-activating proteins is required for Secl4p-dependent Golgi secretory function in yeast. Mol Biol Cell 2002; 13:2193–206.PubMedGoogle Scholar
  128. 128.
    Burger KN. Greasing membrane fusion and fission machineries. Traffic 2000; 1:605–13.PubMedGoogle Scholar
  129. 129.
    Kooijman EE, Chupin V, de Kruijff B et al. Modulation of membrane curvature by phosphatidic acid and lysophosphatidic acid. Traffic 2003; 4:162–74.PubMedGoogle Scholar
  130. 130.
    Kooijman EE, Chupin V, Fuller NL et al. Spontaneous curvature of phosphatidic acid and lysophosphatidic acid. Biochemistry 2005; 44:2097–102.PubMedGoogle Scholar
  131. 131.
    Grote E, Baba M, Ohsumi Y et al. Geranylgeranylated SNAREs are dominant inhibitors of membrane fusion. J Cell Biol 2000; 151:453–66.PubMedGoogle Scholar
  132. 132.
    Praefcke GJ, McMahon HT. The dynamin superfamily: Universal membrane tubulation and fission molecules? Nat Rev Mol Cell Biol 2004; 5:133–47.PubMedGoogle Scholar
  133. 133.
    Burger KN, Demel RA, Schmid SL et al. Dynamin is membrane-active: Lipid insertion is induced by phosphoinositides and phosphatidic acid. Biochemistry 2000; 39:12485–93.PubMedGoogle Scholar
  134. 134.
    Kirchhausen T. Cell biology: Boa constrictor or rattlesnake? Nature 1999; 398:470–1.PubMedGoogle Scholar
  135. 135.
    Sweitzer SM, Hinshaw JE. Dynamin undergoes a GTP-dependent conformational change causing vesiculation. Cell 1998; 93:1021–9.PubMedGoogle Scholar
  136. 136.
    Roux A, Uyhazi K, Frost A et al. GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission. Nature 2006; 441:528–31.PubMedGoogle Scholar
  137. 137.
    Baron CL, Malhotra V. Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane. Science 2002; 295:325–8.PubMedGoogle Scholar
  138. 138.
    Bard F, Malhotra V. The formation of TGN-to-plasma-membrane transport carriers. Annu Rev Cell Dev Biol 2006; 22:439–55.PubMedGoogle Scholar
  139. 139.
    Bonifacino JS, Glick BS. The mechanisms of vesicle budding and fusion. Cell 2004; 116:153–66.PubMedGoogle Scholar
  140. 140.
    Jahn R, Lang T, Sudhof TC. Membrane fusion. Cell2003; 112:519–33.PubMedGoogle Scholar
  141. 141.
    McBride HM, Rybin V, Murphy C et al. Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13. Cell 1999; 98:377–86.PubMedGoogle Scholar
  142. 142.
    Christoforidis S, Miaczynska M, Ashman K et al. Phosphatidylinositol-3-OH kinases are Rab5 effectors. Nat Cell Biol 1999; 1:249–52.PubMedGoogle Scholar
  143. 143.
    Fratti RA, Jun Y, Merz AJ et al. Interdependent assembly of specific regulatory lipids and membrane fusion proteins into the vertex ring domain of docked vacuoles. J Cell Biol 2004; 167:1087–98.PubMedGoogle Scholar
  144. 144.
    Bader MF, Doussau F, Chasserot-Golaz S et al. Coupling actin and membrane dynamics during calcium-regulated exocytosis: A role for Rho and ARF GTPases. Biochim Biophys Acta 2004; 1742:37–49.PubMedGoogle Scholar
  145. 145.
    Sudhof TC. The synaptic vesicle cycle. Annu Rev Neurosci 2004; 27:509–47.PubMedGoogle Scholar
  146. 146.
    Rhee JS, Bettz A, Pyotts A et al. [beta] phorbol ester-and diacylglycerol-induced augmentation of transmitter release is mediated by Muncl3s and not by PKCs. Cell 2002; 108:121–33.PubMedGoogle Scholar
  147. 147.
    Kinuta M, Yamada H, Abe T et al. Phosphatidylinositol 4,5-bisphosphate stimulates vesicle formation from liposomes by brain cytosol. Proc Natl Acad Sei USA 2002; 99:2842–7.Google Scholar
  148. 148.
    Cremona O, Di Paolo G, Wenk MR et al. Essential role of phosphoinositide metabolism in synaptic vesicle recycling. Cell 1999; 99:179–88.PubMedGoogle Scholar
  149. 149.
    Di Paolo G, Moskowitz HS, Gipson K et al. Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking. Nature 2004; 431:415–22.PubMedGoogle Scholar
  150. 150.
    Wucherpfennig T, Wilsch-Brauninger M, Gonzalez-Gaitan M. Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release. J Cell Biol 2003; 161:609–24.PubMedGoogle Scholar
  151. 151.
    Cheever ML, Sato TK, de Beer T et al. Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes. Nat Cell Biol 2001; 3:613–8.PubMedGoogle Scholar
  152. 152.
    Cozier GE, Carlton J, McGregor AH et al. The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation. J Biol Chem 2002; 277:48730–6.PubMedGoogle Scholar
  153. 153.
    Xu Y, Hortsman H, Seet L et al. SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. Nat Cell Biol 2001; 3:658–66.PubMedGoogle Scholar
  154. 154.
    Callaghan J, Nixon S, Bucci C et al. Direct interaction of EEA1 with Rab5b. Eur J Biochem 1999; 265:361–6.PubMedGoogle Scholar
  155. 155.
    Patki V, Virbasius J, Lane WS et al. Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase. Proc Natl Acad Sei USA 1997; 94:7326-30.Google Scholar
  156. 156.
    Komada M, Masaki R, Yamamoto A et al. Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes. J Biol Chem 1997; 272:20538–44.PubMedGoogle Scholar
  157. 157.
    Raiborg C, Bremnes B, Mehlum A et al. FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes. J Cell Sei 2001; 114:2255–63.Google Scholar
  158. 158.
    Ikonomov OC, Sbrissa D, Mlak K et al. Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity. J Biol Chem 2002; 277:9206–11.PubMedGoogle Scholar
  159. 159.
    Chen H, Fre S, Slepnev VI et al. Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. Nature 1998; 394:793–7.PubMedGoogle Scholar
  160. 160.
    Kalthoff C, Groos S, Kohl R et al. Clint: A novel clathrin-binding ENTH-domain protein at the Golgi. Mol Biol Cell 2002; 13:4060–73.PubMedGoogle Scholar
  161. 161.
    Achiriloaie M, Barylko B, Albanesi JP. Essential role of the dynamin pleckstrin homology domain in receptor-mediated endocytosis. Mol Cell Biol 1999; 19:1410–5.PubMedGoogle Scholar
  162. 162.
    Klein DE, Lee A, Frank DW et al. The pleckstrin homology domains of dynamin isoforms require oligomerization for high affinity phosphoinositide binding. J Biol Chem 1998; 273:27725–33.PubMedGoogle Scholar
  163. 163.
    Vallis Y, Wigge P, Marks B et al. Importance of the pleckstrin homology domain of dynamin in clathrin-mediated endocytosis. Curr Biol 1999; 9:257–60.PubMedGoogle Scholar
  164. 164.
    Kam JL, Miura K, Jackson TR et al. Phosphoinositide-dependent activation of the ADP-ribosylation factor GTPase-activating protein ASAP1: Evidence for the pleckstrin homology domain functioning as an allosteric site. J Biol Chem 2000; 275:9653–63.PubMedGoogle Scholar
  165. 165.
    Kavran JM, Klein DE, Lee A et al. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. J Biol Chem 1998; 273:30497–508.PubMedGoogle Scholar
  166. 166.
    Sugars JM, Cellek S, Manifava M et al. Hierarchy of membrane-targeting signals of phospholipase D1 involving lipid modification of a pleckstrin homology domain. J Biol Chem 2002; 277:29152–61.PubMedGoogle Scholar
  167. 167.
    Godi A, Di Campli A, Konstantakopoulos A et al. FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nat Cell Biol 2004; 6:393–404.PubMedGoogle Scholar
  168. 168.
    Levine TP, Munro S. Targeting of Golgi-specific pleckstrin homology domains involves both PtdIns 4-kinase-dependent and-independent components. Curr Biol 2002; 12:695–704.PubMedGoogle Scholar
  169. 169.
    Chung SH, Song WJ, Kim K et al. The C2 domains of Rabphilin3A specifically bind phosphatidylinositol 4,5-bisphosphate containing vesicles in a Ca2+-dependent manner. In vitro characteristics and possible significance. J Biol Chem 1998; 273:10240–8.PubMedGoogle Scholar
  170. 170.
    Zhang X, Rizo J, Sudhof TC. Mechanism of phospholipid binding by the C2A-domain of synaptotagmin I. Biochemistry 1998; 37:12395–403.PubMedGoogle Scholar

Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  1. 1.Signalling ProgrammeBabraham InstituteCambridgeUK

Personalised recommendations