Lipid-Dependent Membrane Remodelling in Protein Trafficking

  • Priya P. Chandra
  • Nicholas T. Ktistakis
Part of the Molecular Biology Intelligence Unit book series (MBIU)


Trafficking pathways of eukaryotic cells exhibit sophisticated interplay between protein and lipid components. The protein molecules and their interacting networks are fairly well characterised. However, the lipid components and their regulation are much less understood. In this chapter, we describe our current understanding of how lipid dynamics can contribute to intracellular trafficking, based on evidence from genetic, biochemical and structural studies. We discuss issues concerning lipid heterogeneity and interconvertibility, and provide examples of how specific lipids can enable membrane remodelling in various transport steps.


Coat Protein Phosphatidic Acid Phosphatidic Acid Lipid Species Protein Trafficking 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  1. 1.Signalling ProgrammeBabraham InstituteCambridgeUK

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