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Endoscopic Techniques for Optical Imaging

  • E. Namati
  • M.J. Suter
  • G. McLennan
Chapter

Abstract

Lung cancer is the leading cause of cancer death in the industrialized world (Landis et al., 1998). Despite recent advancements to reduce the mortality associated with this disease, patient prognosis remains poor, with the current 5-year survival rate under 16%, a rate that has seen no dramatic change over the past 30 years (Jemal et al., 2007; Proctor 2001). It is set to become a worldwide epidemic with the World Health Organization estimating 10 million deaths per year worldwide by the year 2030 (Proctor 2001). While fatal in most cases, early stage lung cancer can be cured. At the time of presentation, less than 15% of patients have localized disease that may be amenable to surgical resection and potential cure; of these patients, the 5-year survival is still a low 60–70%, indicating that even earlier diagnosis is important.

Keywords

Optical Coherence Tomography Sodium Fluorescein Bronchial Mucosa Early Stage Lung Cancer Virtual Bronchoscopy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Aleva, R. M., J. Kraan, M. Smith, N. H. T. Ten Hacken, D. S. Postma, and W. Timens. 1998. Techniques in human airway inflammation: quantity and morphology of bronchial biopsy specimens taken by forceps of three sizes. Chest 113 (1):182–185.PubMedGoogle Scholar
  2. Anandasabapathy, S. 2008. Endoscopic imaging: emerging optical techniques for the detection of colorectal neoplasia. Curr Opin Gastroenterol 24 (1):64–69.PubMedGoogle Scholar
  3. Aziz, D. J., and A. F. Gmitro. 1993. Confocal microscopy via a fiber optic imaging bundle. Paper read at Optical Fibers in Medicine VIII, at Los Angeles, CA, USA.Google Scholar
  4. Aziz, D. J., and A. F. Gmitro. 1994. Imaging performance of the fiber optic image-bundle confocal microscope. Paper read at Microscopy, Holography, and Interferometry in Biomedicine, at Budapest, Hungary.Google Scholar
  5. Baker, K. M., E. Namati, E. Hoffman, E. J. R. Van Beek, A. Ross, and G. McLennan. 2007. Virtual bronchoscopy: new applications for MDCT in pulmonology. Advances in MDCT 3 (4):10–18.Google Scholar
  6. Bard, M. P., A. Amelink, M. Skurichina, M. den Bakker, S. A. Burgers, J. P. van Meerbeeck, R. P. Duin, J. G. Aerts, H. C. Hoogsteden, and H. J. Sterenborg. 2005. Improving the specificity of fluorescence bronchoscopy for the analysis of neoplastic lesions of the bronchial tree by combination with optical spectroscopy: preliminary communication. Lung Cancer 47 (1):41–47.PubMedGoogle Scholar
  7. Beamis, J. F., Jr., A. Ernst, M. Simoff, R. Yung, and P. Mathur. 2004. A multicenter study comparing autofluorescence bronchoscopy to white light bronchoscopy using a non-laser light stimulation system. Chest 125 (5 Suppl):148S–149S.PubMedGoogle Scholar
  8. Becker, V., S. von Delius, M. Bajbouj, A. Karagianni, R. M. Schmid, and A. Meining. 2008. Intravenous application of fluorescein for confocal laser scanning microscopy: evaluation of contrast dynamics and image quality with increasing injection-to-imaging time. Gastrointest Endosc 68(2):319–323.Google Scholar
  9. Bird, D., and M. Gu. 2002. Fibre-optic two-photon scanning fluorescence microscopy. J Microsc 208 (Pt 1):35–48.PubMedGoogle Scholar
  10. Bjarnhall, G., O. Maepea, G. O. Sperber, C. Linden, E. Monestam, and A. Alm. 2002. Analysis of mean retinal transit time from fluorescein angiography in human eyes: normal values and reproducibility. Acata Ophthalmol Scand 80 (6):652–655.Google Scholar
  11. Boguta, A., and D. Wrobel. 2001. Fluorescein and phenolphthalein – correlation of fluorescence and photoelectric properties. J Fluorescence 11 (2):129–137.Google Scholar
  12. Bouma, B. E., G. J. Tearney, C. C. Compton, and N. S. Nishioka. 2000. High-resolution imaging of the human esophagus and stomach in vivo using optical coherence tomography. Gastrointest Endosc 51:467–474.PubMedGoogle Scholar
  13. Brinkmeyer, E., and R. Ulrich. 1990. High-resolution OCDR in dispersive waveguide. Electron Lett 26:413–414.Google Scholar
  14. Browning, D. J. 1999. Fundus photographic, fluorescein angiographic, and indocyanine green angiographic signs in successful laser chorioretinal venous anastomosis for central retinal vein occlusion. Ophthalmology 106 (12):2261–2268.PubMedGoogle Scholar
  15. Carlson, K., M. Chidley, K. B. Sung, M. Descour, A. Gillenwater, M. Follen, and R. Richards-Kortum. 2005. In vivo fiber-optic confocal reflectance microscope with an injection-molded plastic miniature objective lens. Appl Opt 44 (10):1792–1797.PubMedGoogle Scholar
  16. Carlson, A. L., L. G. Coghlan, A. M. Gillenwater, and R. R. Richards-Kortum. 2007a. Dual-mode reflectance and fluorescence near-video-rate confocal microscope for architectural, morphological and molecular imaging of tissue. J Microsc 228 (Pt 1):11–24.PubMedGoogle Scholar
  17. Carlson, A. L., A. M. Gillenwater, M. D. Williams, A. K. El-Naggar, and R. R. Richards-Kortum. 2007b. Confocal microscopy and molecular-specific optical contrast agents for the detection of oral neoplasia. Technol Cancer Res Treat 6 (5):361–374.PubMedGoogle Scholar
  18. Chen, Y., A. D. Aguirre, P-L. Hsiung, S. Desai, P. R. Herz, M. Pedrosa, Q. Huang, M. Figueiredo, S-W. Huang, A. Koski, J. M. Schmitt, J. G. Fujimoto, and H. Mashimo. 2007. Ultrahigh resolution optical coherence tomography of Barrett's esophagus: preliminary descriptive clinical study correlating images with histology. Endoscopy 39 (7):599–605.PubMedGoogle Scholar
  19. Chidley, M. D., K. D. Carlson, R. R. Richards-Kortum, and M. R. Descour. 2006. Design, assembly, and optical bench testing of a high-numerical-aperture miniature injection-molded objective for fiber-optic confocal reflectance microscopy. Appl Opt 45 (11):2545–2554.PubMedGoogle Scholar
  20. Chinn, S. R., E. Swanson, and J. G. Fujimoto. 1997. Optical coherence tomography using a frequency-tunable optical source. Opt Lett 22:340–242.Google Scholar
  21. Chun, J. K., S. Ernst, S. Matthews, B. Schmidt, D. Bansch, S. Boczor, A. Ujeyl, M. Antz, F. Ouyang, and K. H. Kuck. 2007. Remote-controlled catheter ablation of accessory pathways: results from the magnetic laboratory. Eur Heart J 28 (2):190–195.PubMedGoogle Scholar
  22. Collier, T., M. Guillaud, M. Follen, A. Malpica, and R. Richards-Kortum. 2007. Real-time reflectance confocal microscopy: comparison of two-dimensional images and three-dimensional image stacks for detection of cervical precancer. J Biomed Opt 12 (2):024021.PubMedGoogle Scholar
  23. Collier, T., A. Lacy, R. Richards-Kortum, A. Malpica, and M. Follen. 2002. Near real-time confocal microscopy of amelanotic tissue: detection of dysplasia in ex vivo cervical tissue. Acad Radiol 9 (5):504–512.PubMedGoogle Scholar
  24. Deinert, K., R. Kiesslich, M. Vieth, M. F. Neurath, and H. Neuhaus. 2007. In-vivo microvascular imaging of early squamous-cell cancer of the esophagus by confocal laser endomicroscopy. Endoscopy 39 (4):366–368.PubMedGoogle Scholar
  25. Delaney, P. M., M. R. Harris, and R. G. King. 1993. Novel microscopy using fibre optic confocal imaging and its suitability for subsurface blood vessel imaging in vivo. Clin Exp Pharmacol Physiol 20 (3):197–198.PubMedGoogle Scholar
  26. Delaney, P. M., R. G. King, J. R. Lambert, and M. R. Harris. 1994. Fibre optic confocal imaging (FOCI) for subsurface microscopy of the colon in vivo. J Anat 184 ( Pt 1):157–160.PubMedGoogle Scholar
  27. Di Biase, L., T. S. Fahmy, D. Patel, R. Bai, K. Civello, O. M. Wazni, M. Kanj, C. S. Elayi, C. K. Ching, M. Khan, L. Popova, R. A. Schweikert, J. E. Cummings, J. D. Burkhardt, D. O. Martin, M. Bhargava, T. Dresing, W. Saliba, M. Arruda, and A. Natale. 2007. Remote magnetic navigation: human experience in pulmonary vein ablation. J Am Coll Cardiol 50 (9):868–874.PubMedGoogle Scholar
  28. Dickensheets, D. L., and G. S. Kino. 1996. Micromachined scaning confocal optical microscope. 21(10):764–766.Google Scholar
  29. Drezek, R. A., T. Collier, C. K. Brookner, A. Malpica, R. Lotan, R. R. Richards-Kortum, and M. Follen. 2000. Laser scanning confocal microscopy of cervical tissue before and after application of acetic acid. Am J Obstet Gynecol 182 (5):1135–1139.PubMedGoogle Scholar
  30. Eberhardt, R., D. Anantham, A. Ernst, D. Feller-Kopman, and F. Herth. 2007a. Multimodality bronchoscopic diagnosis of peripheral lung lesions: a randomized controlled trial. Am J Respir Crit Care Med 176 (1):36–41.PubMedGoogle Scholar
  31. Eberhardt, R., D. Anantham, F. Herth, D. Feller-Kopman, and A. Ernst. 2007b. Electromagnetic navigation diagnostic bronchoscopy in peripheral lung lesions. Chest 131 (6):1800–1805.PubMedGoogle Scholar
  32. Ernst, S., F. Ouyang, C. Linder, K. Hertting, F. Stahl, J. Chun, H. Hachiya, D. Bansch, M. Antz, and K. H. Kuck. 2004. Initial experience with remote catheter ablation using a novel magnetic navigation system: magnetic remote catheter ablation. Circulation 109 (12):1472–1475.PubMedGoogle Scholar
  33. Ernst, A., M. J. Simoff, P. N. Mathur, R. C. Yung, and J. F. Beamis. 2005. D-light autofluorescence in the detection of premalignant airway changes: a multicenter trial. J Bronchology 12 (3):133–138.Google Scholar
  34. Feller-Kopman, D., W. Lunn, and A. Ernst. 2005. Autofluorescence bronchoscopy and endobronchial ultrasound: a practical review. Ann Thorac Surg 80 (6):2395–2401.PubMedGoogle Scholar
  35. Ferguson, J. S., and G. McLennan. 2005. Virtual bronchoscopy. Proc Am Thorac Soc 2 (6):488–491, 504–505.PubMedGoogle Scholar
  36. Ferretti, G. R., J. Knoplioch, I. Bricault, C. Brambilla, and M. Coulomb. 1997. Central airway stenoses: preliminary results of spiral-CT-generated virtual bronchoscopy simulations in 29 patients. Eur Radiol 7 (6):854–859.PubMedGoogle Scholar
  37. Ferretti, G., J. Knoplioch, M. Coulomb, C. Brambilla, and P. Cinquin. 1995. [Endoluminal 3D reconstruction of the tracheo-bronchial tree (virtual bronchoscopy)]. J Radiol 76 (8):531–534.PubMedGoogle Scholar
  38. Flower, R. W. 1973. Injection technique for indocyanine green and sodium fluorescein dye angiography of the eye. Invest Ophthalmol 12 (12):881–903.PubMedGoogle Scholar
  39. Flusberg, B. A., E. D. Cocker, W. Piyawattanametha, J. C. Jung, E. L. Cheung, and M. J. Schnitzer. 2005a. Fiber-optic fluorescence imaging. Nat Methods 2 (12):941–950.PubMedGoogle Scholar
  40. Flusberg, B. A., J. C. Jung, E. D. Cocker, E. P. Anderson, and M. J. Schnitzer. 2005b. In vivo brain imaging using a portable 3.9 gram two-photon fluorescence microendoscope. Opt Lett 30 (17):2272–2274.PubMedGoogle Scholar
  41. Fujimoto, J. G., M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson. 1995. Optical biopsy and imaging using optical coherence tomography. Nat Med 1 (9):970–972.PubMedGoogle Scholar
  42. Fujimoto, J. G., C. Pitris, S. A. Boppart, and M. E. Brezinski. 2000. Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy. Neoplasia 2 (1–2):9–25.PubMedGoogle Scholar
  43. Gildea, T. R., P. J. Mazzone, D. Karnak, M. Meziane, and A. C. Mehta. 2006. Electromagnetic navigation diagnostic bronchoscopy: a prospective study. Am J Respir Crit Care Med 174 (9):982–989.PubMedGoogle Scholar
  44. Gobel, W., J. N. Kerr, A. Nimmerjahn, and F. Helmchen. 2004. Miniaturized two-photon microscope based on a flexible coherent fiber bundle and a gradient-index lens objective. Opt Lett 29 (21):2521–2523.PubMedGoogle Scholar
  45. Goetz, M., A. Hoffman, P. R. Galle, M. F. Neurath, and R. Kiesslich. 2006. Confocal laser endoscopy: new approach to the early diagnosis of tumors of the esophagus and stomach. Future Oncol 2 (4):469–476.PubMedGoogle Scholar
  46. Goetz, M., and R. Kiesslich. 2008. Confocal endomicroscopy: in vivo diagnosis of neoplastic lesions of the gastrointestinal tract. Anticancer Res 28 (1B):353–360.Google Scholar
  47. Golubovic, B., B. E. Bouma, G. J. Tearney, and J. G. Fujimoto. 1997. Optical frequency-domain reflectometry using rapid wavelength tuning of a Cr4+:forsterite laser. Optics Letters 22:1704–1706.PubMedGoogle Scholar
  48. Gopalakrishnan, D. 2003. Color Analysis of the Human Airway Wall. Master of Science, Dept of Biomedical Engineering, University of Iowa, Iowa City.Google Scholar
  49. Grady, M. S., M. A. Howard, 3rd, J. A. Molloy, R. C. Ritter, E. G. Quate, and G. T. Gillies. 1989. Preliminary experimental investigation of in vivo magnetic manipulation: results and potential application in hyperthermia. Med Phys 16 (2):263–272.PubMedGoogle Scholar
  50. Grady, M. S., M. A. Howard, 3rd, J. A. Molloy, R. C. Ritter, E. G. Quate, and G. T. Gillies. 1990. Nonlinear magnetic stereotaxis: three-dimensional, in vivo remote magnetic manipulation of a small object in canine brain. Med Phys 17 (3):405–415.PubMedGoogle Scholar
  51. Graham, M. W., J. D. Gibbs, and W. E. Higgins. 2008. Robust system for human airway-tree segmentation. Paper read at Medical Imaging, at San Diego.Google Scholar
  52. Haussinger, K., H. Becker, F. Stanzel, A. Kreuzer, B. Schmidt, J. Strausz, S. Cavaliere, F. Herth, M. Kohlhaufl, K. M. Muller, R. M. Huber, U. Pichlmeier, and T. Bolliger Ch. 2005. Autofluorescence bronchoscopy with white light bronchoscopy compared with white light bronchoscopy alone for the detection of precancerous lesions: a European randomised controlled multicentre trial. Thorax 60 (6):496–503.PubMedGoogle Scholar
  53. Heckly, B. G., L. Thiberville, C. Vever-Bizet, and B. Viellerobe. 2008. In vivo endoscopic autofluorescence microspectro-imaging of bronchi and alveoli. Paper read at SPIE: Endoscopic Microscopy III,Google Scholar
  54. Hendee, W. R. 2002. Confocal microscopy: a new technique for in vivo imaging. Acad Radiol 9 (5):503.PubMedGoogle Scholar
  55. Herth, F. J., R. Eberhardt, and A. Ernst. 2006. The future of bronchoscopy in diagnosing, staging and treatment of lung cancer. Respiration 73 (4):399–409.PubMedGoogle Scholar
  56. Higgins, W. E., K. Ramaswamy, R. D. Swift, G. McLennan, and E. A. Hoffman. 1998. Virtual bronchoscopy for three–dimensional pulmonary image assessment: state of the art and future needs. Radiographics 18 (3):761–778.PubMedGoogle Scholar
  57. Hoffman, A., M. Goetz, M. Vieth, P. R. Galle, M. F. Neurath, and R. Kiesslich. 2006. Confocal laser endomicroscopy: technical status and current indications. Endoscopy 38 (12):1275–1283.PubMedGoogle Scholar
  58. Hsiung, P-L., L. Pantanowitz, A. D. Aguirre, Y. Chen, D. Phatak, T. H. Ko, S. Bourquin, S. J. Schnitt, S. Raza, J. L. Connolly, H. Mashimo, and J. G. Fujimoto. 2005. Ultrahigh-resolution and 3-dimensional optical coherence tomography ex vivo imaging of the large and small intestines. Gastrointest Endosc 62 (4):561–574.PubMedGoogle Scholar
  59. Hurlstone, D. P., W. Baraza, S. Brown, M. Thomson, N. Tiffin, and S. S. Cross. 2008. In vivo real-time confocal laser scanning endomicroscopic colonoscopy for the detection and characterization of colorectal neoplasia. Br J Surg 95 (5):636–645.PubMedGoogle Scholar
  60. Hurlstone, D. P., and D. S. Sanders. 2006. Recent advances in chromoscopic colonoscopy and endomicroscopy. Curr Gastroenterol Rep 8 (5):409–415.PubMedGoogle Scholar
  61. Hurlstone, D. P., N. Tiffin, S. R. Brown, W. Baraza, M. Thomson, and S. S. Cross. 2008. In vivo confocal laser scanning chromo-endomicroscopy of colorectal neoplasia: changing the technological paradigm. Histopathology 52 (4):417–426.PubMedGoogle Scholar
  62. Ikeda, N., A. Hayashi, K. Iwasaki, M. Tsuboi, J. Usuda, and H. Kato. 2007. Comprehensive diagnostic bronchoscopy of central type early stage lung cancer. Lung Cancer 56 (3):295–302.PubMedGoogle Scholar
  63. Ikeda, S., N. Yanai, and S. Ishikawa. 1968. Flexible bronchofiberscope. Keio J Med 17 (1):1–16.PubMedGoogle Scholar
  64. Jemal, A., R. Siegel, E. Ward, T. Murray, J. Xu, and M. J. Thun. 2007. Cancer statistics, 2007. CA Cancer J Clin 57 (1):43–66.PubMedGoogle Scholar
  65. Jung, J. C., and M. J. Schnitzer. 2003. Multiphoton endoscopy. Opt Lett 28 (11):902–904.PubMedGoogle Scholar
  66. Kakeji, Y., S. Yamaguchi, D. Yoshida, K. Tanoue, M. Ueda, A. Masunari, T. Utsunomiya, M. Imamura, H. Honda, Y. Maehara, and M. Hashizume. 2006. Development and assessment of morphologic criteria for diagnosing gastric cancer using confocal endomicroscopy: an ex vivo and in vivo study. Endoscopy 38 (9):886–890.PubMedGoogle Scholar
  67. Kennedy, T. C., S. Lam, and F. R. Hirsch. 2001. Review of recent advances in fluorescence bronchoscopy in early localization of central airway lung cancer. Oncologist 6 (3):257–262.PubMedGoogle Scholar
  68. Kerr, K. M. 2001. Pulmonary preinvasive neplasia. J Clin Pathol 54:257–271.PubMedGoogle Scholar
  69. Kiemeneij, F., M. S. Patterson, G. Amoroso, G. Laarman, and T. Slagboom. 2008. Use of the Stereotaxis Niobe magnetic navigation system for percutaneous coronary intervention: results from 350 consecutive patients. Catheter Cardiovasc Interv 71 (4):510–516.PubMedGoogle Scholar
  70. Kiesslich, R., M. Goetz, K. Lammersdorf, C. Schneider, J. Burg, M. Stolte, M. Vieth, B. Nafe, P. R. Galle, and M. F. Neurath. 2007a. Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis. Gastroenterology 132 (3):874–882.PubMedGoogle Scholar
  71. Kiesslich, R., M. Goetz, M. Vieth, P. R. Galle, and M. F. Neurath. 2005. Confocal laser endomicroscopy. Gastrointest Endosc Clin N Am 15 (4):715–731.PubMedGoogle Scholar
  72. Kiesslich, R., M. Goetz, M. Vieth, P. R. Galle, and M. F. Neurath. 2007b. Technology insight: confocal laser endoscopy for in vivo diagnosis of colorectal cancer. Nat Clin Pract Oncol 4 (8):480–490.PubMedGoogle Scholar
  73. Kiesslich, R., L. Gossner, M. Goetz, A. Dahlmann, M. Vieth, M. Stolte, A. Hoffman, M. Jung, B. Nafe, P. R. Galle, and M. F. Neurath. 2006a. In vivo histology of Barrett's esophagus and associated neoplasia by confocal laser endomicroscopy. Clin Gastroenterol Hepatol 4 (8):979–887.Google Scholar
  74. Kiesslich, R., A. Hoffman, M. Goetz, S. Biesterfeld, M. Vieth, P. R. Galle, and M. F. Neurath. 2006b. In vivo diagnosis of collagenous colitis by confocal endomicroscopy. Gut 55 (4):591–592.PubMedGoogle Scholar
  75. Kiesslich, R., and M. F. Neurath. 2005. Endoscopic confocal imaging. Clin Gastroenterol Hepatol 3 (7 Suppl 1):S58–S60.PubMedGoogle Scholar
  76. Kiesslich, R., and M. F. Neurath. 2006. Chromoendoscopy and other novel imaging techniques. Gastroenterol Clin North Am 35 (3):605–619.PubMedGoogle Scholar
  77. Kiesslich, R., and M. F. Neurath. 2007. Endomicroscopy is born–do we still need the pathologist? Gastrointest Endosc 66 (1):150–153.PubMedGoogle Scholar
  78. Killian, G. 1898. Úber direkte Bronchoscopie. MMW 45 (27):844–847.Google Scholar
  79. Kim, P., M. Puoris'haag, D. Cote, C. P. Lin, and S. H. Yun. 2008. In vivo confocal and multiphoton microendoscopy. J Biomed Opt 13 (1):010501.PubMedGoogle Scholar
  80. King, R. G., and P. M. Delaney. 1994. Confocal microscopy in pharmacological research. Trends Pharmacol Sci 15 (8):275–279.PubMedGoogle Scholar
  81. Kiraly, A. P., J. P. Helferty, E. A. Hoffman, G. McLennan, and W. E. Higgins. 2004. Three-dimensional path planning for virtual bronchoscopy. IEEE Trans Med Imaging 23 (11):1365–1379.PubMedGoogle Scholar
  82. Kiraly, A. P., W. E. Higgins, G. McLennan, E. A. Hoffman, and J. M. Reinhardt. 2002. Three-dimensional human airway segmentation methods for clinical virtual bronchoscopy. Acad Radiol 9 (10):1153–1168.PubMedGoogle Scholar
  83. Kitabatake, S., Y. Niwa, R. Miyahara, A. Ohashi, T. Matsuura, Y. Iguchi, Y. Shimoyama, T. Nagasaka, O. Maeda, T. Ando, N. Ohmiya, A. Itoh, Y. Hirooka, and H. Goto. 2006. Confocal endomicroscopy for the diagnosis of gastric cancer in vivo. Endoscopy 38 (11):1110–1114.PubMedGoogle Scholar
  84. Knyrim, K., H. K. Seidlitz, F. Hagenmuller, and M. Classen. 1987. Color performance of video endoscopes: quantitative measurement of color reproduction. Endoscopy 19 (6):233–236.PubMedGoogle Scholar
  85. Lam, S., C. MacAulay, J. Hung, J. LeRiche, A. E. Profio, and B. Palcic. 1993. Detection of dysplasia and carcinoma in situ with a lung imaging fluorescence endoscope device. J Thorac Cardiovasc Surg 105 (6):1035–1040.PubMedGoogle Scholar
  86. Lam, S., C. MacAulay, J. C. leRiche, and B. Palcic. 2000. Detection and localization of early lung cancer by fluorescence bronchoscopy. Cancer 89 (11 Suppl):2468–2473.PubMedGoogle Scholar
  87. Lam, S., B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay. 2008. In vivo optical coherence tomography imaging of preinvasive bronchial lesions. Clin Cancer Res 14 (7):2006–2011.PubMedGoogle Scholar
  88. Landis, S. H., T. Murray, S. Bolden, and P. A. Wingo. 1998. Cancer statistics, 1998. CA Cancer J Clin 48 (1):6–29.PubMedGoogle Scholar
  89. Lexer, F., C. K. Hitzenberger, A. F. Fercher, and M. Kulhavy. 1997. Wavelength-tuning interferometry of intraocular distances. Appl Opt 36:6548–6553.PubMedGoogle Scholar
  90. Liu, H., Y. Q. Li, T. Yu, Y. A. Zhao, J. P. Zhang, J. N. Zhang, Y. T. Guo, X. J. Xie, T. G. Zhang, and P. V. Desmond. 2008. Confocal endomicroscopy for in vivo detection of microvascular architecture in normal and malignant lesions of upper gastrointestinal tract. J Gastroenterol Hepatol 23 (1):56–61.PubMedGoogle Scholar
  91. Liu, J. T., M. J. Mandella, S. Friedland, R. Soetikno, J. M. Crawford, C. H. Contag, G. S. Kino, and T. D. Wang. 2006. Dual-axes confocal reflectance microscope for distinguishing colonic neoplasia. J Biomed Opt 11 (5):054019.PubMedGoogle Scholar
  92. Liu, J. T., M. J. Mandella, H. Ra, L. K. Wong, O. Solgaard, G. S. Kino, W. Piyawattanametha, C. H. Contag, and T. D. Wang. 2007. Miniature near-infrared dual-axes confocal microscope utilizing a two-dimensional microelectromechanical systems scanner. Opt Lett 32 (3):256–258.PubMedGoogle Scholar
  93. MacAulay, C., P. Lane, and R. Richards-Kortum. 2004. In vivo pathology: microendoscopy as a new endoscopic imaging modality. Gastrointest Endosc Clin N Am 14 (3):595–620, xi.PubMedGoogle Scholar
  94. Maitland, K. C., A. M. Gillenwater, M. D. Williams, A. K. El-Naggar, M. R. Descour, and R. R. Richards-Kortum. 2008. In vivo imaging of oral neoplasia using a miniaturized fiber optic confocal reflectance microscope. Oral Oncol 44(11):1059–1066.Google Scholar
  95. Makris, D., and K. I. Gourgoulianis. 2008. Electromagnetic navigation diagnostic bronchoscopy and transbronchial biopsy. Chest 133 (3):829–830.PubMedGoogle Scholar
  96. MaunaKeaTechnologies 2008. Mauna Kea Technologies 2008 [cited. Available from http://www.maunakeatech.com.
  97. McLennan, G., J. S. Ferguson, K. Thomas, A. S. Delsing, J. Cook-Granroth, and E. A. Hoffman. 2007a. The use of MDCT-based computer-aided pathway finding for mediastinal and perihilar lymph node biopsy: a randomized controlled prospective trial. Respiration 74 (4):423–431.PubMedGoogle Scholar
  98. McLennan, G., E. Namati, J. Ganatra, M. Suter, E. E. O'Brien, K. Lecamwasam, E. J. R. Van Beek, and E. Hoffman. 2007b. Virtual Bronchoscopy. MRI 11 (1):10–20.Google Scholar
  99. McPherson, C. M., and R. E. Warnick. 2004. Results of contemporary surgical management of radiation necrosis using frameless stereotaxis and intraoperative magnetic resonance imaging. J Neurooncol 68 (1):41–47.PubMedGoogle Scholar
  100. McWilliams, A., C. MacAulay, A. F. Gazdar, and S. Lam. 2002. Innovative molecular and imaging approaches for the detection of lung cancer and its precursor lesions. Oncogene 21 (45):6949–6959.PubMedGoogle Scholar
  101. Mehta, R., D. T. Hart, B. S. Nagra, Z. Liu, and B. K. Kantharia. 2008. Successful ablation of focal left atrial tachycardia using Stereotaxis Niobe remote magnetic navigation system. Europace 10 (3):280–283.PubMedGoogle Scholar
  102. Miehlke, S., A. Morgner, D. Aust, A. Madisch, M. Vieth, and G. Baretton. 2007. Combined use of narrow-band imaging magnification endoscopy and miniprobe confocal laser microscopy in neoplastic Barrett’s esophagus. Endoscopy 39 Suppl 1:E316.PubMedGoogle Scholar
  103. Minsky, M. 1961. Microscopy apparatus, edited by U. P. Office, USA.Google Scholar
  104. Minsky, M. 1988. Memoir on inventing the confocal microscope. Scanning 10:128–138.Google Scholar
  105. Myaing, M. T., D. J. MacDonald, and X. Li. 2006. Fiber-optic scanning two-photon fluorescence endoscope. Opt Lett 31 (8):1076–1078.PubMedGoogle Scholar
  106. Namati, E., J. Thiesse, J. de Ryk, and G. McLennan. 2007a. Dynamic in vivo alveolar morphology using a novel laser scanning confocal microscope. Paper read at 9th Biennial Conference of the Australian Pattern Recognition Society on Digital Image Computing Techniques and Applications (DICTA 2007), 05/12/2007, at Adelaide, Australia.Google Scholar
  107. Namati, E., J. Thiesse, J. de Ryk, and G. McLennan. 2007b. In vivo imaging of alveoli. Paper read at American Thoracic Society, 05/21/2007, at San Francisco, CA.Google Scholar
  108. Namati, E., J. Thiesse, J. de Ryk, and G. McLennan. 2008a. Alveolar Dynamics during respiration: are the pores of Kohn a pathway to recruitment? Am J Respir Cell Mol Biol 38 (5):572–578.PubMedGoogle Scholar
  109. Namati, E., J. Thiesse, J. de Ryk, and G. McLennan. 2008b. In vivo catheter-based histopathology of lung cancer in mice. Paper read at American Thoracic Society, 05/20/2008, at Toronto, Canada.Google Scholar
  110. Namati, E., J. Thiesse, J. de Ryk, and G. McLennan. 2008c. Longitudinal multi-modality three-dimensional imaging of lung cancer in mice. Paper read at American Thoracic Society, 05/19/2008, at Toronto, Canada.Google Scholar
  111. Negahdar, M., A. Ahmadian, N. Navab, and K. Firouznia. 2006. Path planning for virtual bronchoscopy. Conf Proc IEEE Eng Med Biol Soc 1:156–159.PubMedGoogle Scholar
  112. Pech, O., T. Rabenstein, H. Manner, M. C. Petrone, J. Pohl, M. Vieth, M. Stolte, and C. Ell. 2008. Confocal laser endomicroscopy for in vivo diagnosis of early squamous cell carcinoma in the esophagus. Clin Gastroenterol Hepatol 6 (1):89–94.PubMedGoogle Scholar
  113. Polglase, A. L., W. J. McLaren, and P. M. Delaney. 2006. Pentax confocal endomicroscope: a novel imaging device for in vivo histology of the upper and lower gastrointestinal tract. Expert Rev Med Devices 3 (5):549–556.PubMedGoogle Scholar
  114. Polglase, A. L., W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney. 2005. A fluorescence confocal endomicroscope for in vivo microscopy of the upper- and the lower-GI tract. Gastrointest Endosc 62 (5):686–695.PubMedGoogle Scholar
  115. Proctor, R. N. 2001. Tobacco and the global lung cancer epidemic. Nat Rev Cancer 1 (1):82–86.PubMedGoogle Scholar
  116. Rector, D. M., D. M. Ranken, and J. S. George. 2003. High-performance confocal system for microscopic or endoscopic applications. Methods 30 (1):16–27.PubMedGoogle Scholar
  117. Richards-Kortum, R., and E. Sevick-Muraca. 1996. Quantitative optical spectroscopy for tissue diagnosis. Annu Rev Phys Chem 47:555–606.PubMedGoogle Scholar
  118. Riker, D. R., J. Scott Ferguson, K. J. Sprenger, S. Nibaur, K. Baker, J. Tschirren, P. H. Burmeister, and G. McLennan. 2007. Magnetic Navigation Guided Videobronchoscopy. Paper read at American Thoracic Society, 05/22/2007, at San Diego.Google Scholar
  119. Rogers, C. S., W. M. Abraham, K. A. Brogden, J. F. Engelhardt, J. T. Fisher, P. B. McCray Jr, G. McLennan, D. K. Meyerholz, E. Namati, L. S. Ostedgaard, R. S. Prather, J. R. Sabater, D. A. Stoltz, J. Zabner, and M. J. Welsh. 2008. The porcine lung as a potential model for cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 295(2):L240–L263.Google Scholar
  120. Rouse, A. R., and A. F. Gmitro. 2000. Multispectral imaging with a confocal microendoscope. Opt Lett 25 (23):1708–1710.PubMedGoogle Scholar
  121. Rouse, A. R., A. Kano, J. A. Udovich, S. M. Kroto, and A. F. Gmitro. 2004. Design and demonstration of a miniature catheter for a confocal microendoscope. Appl Opt 43 (31):5763–571.Google Scholar
  122. Sabharwal, Y. S., A. R. Rouse, L. Donaldson, M. F. Hopkins, and A. F. Gmitro. 1999. Slit-scanning confocal microendoscope for high-resolution in vivo imaging. Appl Opt 38 (34):7133–7144.PubMedGoogle Scholar
  123. Schwarz, Y., J. Greif, H. D. Becker, A. Ernst, and A. Mehta. 2006. Real-time electromagnetic navigation bronchoscopy to peripheral lung lesions using overlaid CT images: the first human study. Chest 129 (4):988–994.PubMedGoogle Scholar
  124. Schwarz, Y., A. C. Mehta, A. Ernst, F. Herth, A. Engel, D. Besser, and H. D. Becker. 2003. Electromagnetic navigation during flexible bronchoscopy. Respiration 70 (5):516–522.PubMedGoogle Scholar
  125. Seijo, L. M., G. Bastarrika, M. D. Lozano, and J. J. Zulueta. 2007. [Preliminary experience with the use of electromagnetic navigation for the diagnosis of peripheral pulmonary nodules and enlarged mediastinal lymph nodes]. Arch Bronconeumol 43 (8):460–463.PubMedGoogle Scholar
  126. Sergeev, A. M., V. M. Gelikonov, G. V. Gelikonov, F. L. Feldchtein, R. V. Kuranov, N. D. Gladkova, N. M. Shakhova, L. B. Suopova, A. V. Shakhov, I. A. Kuznetzova, A. N. Denisenko, V. V. Pochinki, Y. P. Chumakoc, and O. S. Streltzova. 1997. In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa. Opt Express 1:432–1440.PubMedGoogle Scholar
  127. Sivak, M. V., Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis. 2000. High-resolution endoscopic imaging of the GI tract using optical coherence tomography. Gastrointest Endosc 51:474–479.PubMedGoogle Scholar
  128. Smithpeter, C. L., A. K. Dunn, A. J. Welch, and R. Richards-Kortum. 1998. Penetration depth limits of in vivo confocal reflectance imaging. Appl Opt 37 (13):2749–2754.PubMedGoogle Scholar
  129. Summers, R. M., D. H. Feng, S. M. Holland, M. C. Sneller, and J. H. Shelhamer. 1996. Virtual bronchoscopy: segmentation method for real-time display. Radiology 200 (3):857–862.PubMedGoogle Scholar
  130. Sung, K. B., C. Liang, M. Descour, T. Collier, M. Follen, and R. Richards-Kortum. 2002. Fiber-optic confocal reflectance microscope with miniature objective for in vivo imaging of human tissues. IEEE Trans Biomed Eng 49 (10):1168–1172.PubMedGoogle Scholar
  131. Sutedja, G. 2003. New techniques for early detection of lung cancer. Eur Respir J Suppl 39:57 s–66 s.Google Scholar
  132. Suter, M. J. 2005. Multi-modal Structural and Functional Description and Analyses of the Pulmonary Airway Mucosa, Department of Biomedical Engineering, University of Iowa, Iowa City.Google Scholar
  133. Suter, M. J., D. K. Kang, B. E. Bouma, and G. J. Tearney. 2008a. Multi-modal optical imaigng of the swine airways ex vivo. Paper read at American Thoracic Society, at Toronto, Canada.Google Scholar
  134. Suter, M. J., G. McLennan, J. M. Reinhardt, P. R. Montaue, P. Taft, J. Lee, and J. Zabner. 2005a. Bronchoscopic imaging of pulmonary mucosal vasculature responses to inflammatory mediators. J Biomed Opt 10 (3):034013.PubMedGoogle Scholar
  135. Suter, M., G. McLennan, J. M. Reinhardt, D. Riker, and E. A. Hoffman. 2005b. Macro-optical color assessment of the pulmonary airways with subsequent three-dimensional multidetector-x-ray-computed-tomography assisted display. J Biomed Opt 10 (5):051703.PubMedGoogle Scholar
  136. Suter, M. J., J. M. Reinhardt, and G. McLennan. 2008b. Integrated CT/bronchoscopy in the central airways preliminary results. Acad Radiol 15 (6):786–798.PubMedGoogle Scholar
  137. Suter, M., J. Reinhardt, P. Montague, P. Taft, J. Lee, J. Zabner, and G. McLennan. 2005c. Bronchoscopic imaging of pulmonary mucosal vasculature responses to inflammatory mediators. J Biomed Opt 10 (3):034013.PubMedGoogle Scholar
  138. Suter, M., J. M. Reinhardt, D. Riker, W. E. Higgins, E. A. Hoffman, and G. McLennan. 2005d. Macro-optical color assessment of the pulmonary airways with subsequent 3D MDCT assisted display. J Biomed Opt 10 (5):051703.PubMedGoogle Scholar
  139. Suter, M. J., J. M. Reinhardt, M. Sonka, W. E. Higgins, E. A. Hoffman, and G. McLennan. 2004a. Three dimensional true color topographical analysis of the pulmonary airways. Paper read at SPIE Conference on Medical Imaging, at San Diego.Google Scholar
  140. Suter, M. J., J. Tschirren, J. M. Reinhardt, M. Sonka, E. A. Hoffman, W. E. Higgins, and G. McLennan. 2004b. Evaluation of the human airway with multidetector X-ray computed tomography and optical imaging. Physiol Meas 25 (4):837–847.PubMedGoogle Scholar
  141. Tan, J., P. Delaney, and W. J. McLaren. 2007. Confocal endomicroscopy: a novel imaging technique for in vivo histology of cervical intraepithelial neoplasia. Expert Rev Med Devices 4 (6):863–871.PubMedGoogle Scholar
  142. Tearney, G. J., M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southem, and J. G. Fujimoto. 1997. In vivo endoscopic optical biopsy with optical coherence tomography. Science 276:2037–2039.PubMedGoogle Scholar
  143. Thiberville, L., G. B. Heckly, E. Peltier, and C. Cave. 2006. Perendoscopic alveolar imaging using fluorescent confocal fibered microscopy. Paper read at European Respiratory Society 2006.Google Scholar
  144. Thiberville, L., S. Moreno-Swirc, T. Vercauteren, E. Peltier, C. Cave, and G. B. Heckly. 2007. In vivo imaging of the bronchial wall microstructure using fibered confocal fluorescence microscopy. Am J Respir Crit Care Med 175 (1):22–31.PubMedGoogle Scholar
  145. Thong, P. S., M. Olivo, K. W. Kho, W. Zheng, K. Mancer, M. Harris, and K. C. Soo. 2007. Laser confocal endomicroscopy as a novel technique for fluorescence diagnostic imaging of the oral cavity. J Biomed Opt 12 (1):014007.PubMedGoogle Scholar
  146. Tschirren, J., E. A. Hoffman, G. McLennan, and M. Sonka. 2005a. Intrathoracic airway trees: segmentation and airway morphology analysis from low-dose CT scans. IEEE Trans Med Imaging 24 (12):1529–1539.PubMedGoogle Scholar
  147. Tschirren, J., E. A. Hoffman, G. McLennan, and M. Sonka. 2005b. Segmentation and quantitative analysis of intrathoracic airway trees from computed tomography images. Proc Am Thorac Soc 2 (6):484–487, 503–504.PubMedGoogle Scholar
  148. Tschirren, J., G. McLennan, K. Palagyi, E. A. Hoffman, and M. Sonka. 2005. Matching and anatomical labeling of human airway tree. IEEE Trans Med Imaging 24 (12):1540–1547.PubMedGoogle Scholar
  149. Tsuboi, M., A. Hayashi, N. Ikeda, H. Honda, Y. Kato, S. Ichinose, and H. Kato. 2005. Optical coherence tomography in the diagnosis of bronchial lesions. Lung Cancer 49:387–394.PubMedGoogle Scholar
  150. Vincent, B. D., M. Fraig, and G. A. Silvestri. 2007. A pilot study of narrow-band imaging compared to white light bronchoscopy for evaluation of normal airways and premalignant and malignant airways disease. Chest 131 (6):1794–1799.PubMedGoogle Scholar
  151. Vining, D. J., K. Liu, R. H. Choplin, and E. F. Haponik. 1996. Virtual bronchoscopy. Relationships of virtual reality endobronchial simulations to actual bronchoscopic findings. Chest 109 (2):549–553.PubMedGoogle Scholar
  152. Wang, T. D., C. H. Contag, M. J. Mandella, N. Y. Chan, and G. S. Kino. 2003a. Dual-axes confocal microscopy with post-objective scanning and low-coherence heterodyne detection. Opt Lett 28 (20):1915–1917.PubMedGoogle Scholar
  153. Wang, T. D., C. H. Contag, M. J. Mandella, N. Y. Chan, and G. S. Kino. 2004. Confocal fluorescence microscope with dual-axis architecture and biaxial postobjective scanning. J Biomed Opt 9 (4):735–742.PubMedGoogle Scholar
  154. Wang, T. D., M. J. Mandella, C. H. Contag, and G. S. Kino. 2003b. Dual-axis confocal microscope for high-resolution in vivo imaging. Opt Lett 28 (6):414–416.PubMedGoogle Scholar
  155. Weissleder, R., and M. J. Pittet. 2008. Imaging in the era of molecular oncology. Nature 452 (7187):580–589.PubMedGoogle Scholar
  156. Whiteman, S. C., Y. Yang, D. G. van Pittius, M. Stephens, J. Parmer, and M. A. Spiteri. 2006. Optical coherence tomography: real-time imaging of bronchial airways microstructure and detection of inflammatory/neoplastic morphologic changes. Clin Cancer Res 12 (3):813–818.PubMedGoogle Scholar
  157. Yang, Y., S. C. Whiteman, D. G. van Pittius, Y. He, R. K. Wang, and M. A. Spiteri. 2004. Use of optical coherence tomography in delineating airways microstructure: comparison of OCT images to histopathological sections. Phys Med Biol 49 (7):1247–1255.PubMedGoogle Scholar
  158. Yun, S. H., C. Boudoux, G. J. Tearney, and B. E. Bouma. 2003. High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter. Opt Lett 28:1981–1983.PubMedGoogle Scholar
  159. Yun, S. H., G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma. 2003. High-speed optical frequency-domain imaging. Opt Express 11 (22):2953–2963.PubMedGoogle Scholar
  160. Yun, S. H., G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma. 2006. Comprehensive volumetric optical microscopy in vivo. Nat Med 12 (12):1429–1433.PubMedGoogle Scholar
  161. Zheng, W., M. Harris, K. W. Kho, P. S. Thong, A. Hibbs, M. Olivo, and K. C. Soo. 2004. Confocal endomicroscopic imaging of normal and neoplastic human tongue tissue using ALA-induced-PPIX fluorescence: a preliminary study. Oncol Rep 12 (2):397–401.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • E. Namati
    • 1
  • M.J. Suter
    • 2
  • G. McLennan
    • 1
  1. 1.Department of Internal Medicine, Carver College of MedicineUniversity of IowaIowa CityUSA
  2. 2.Harvard Medical School, Wellman Center for PhotomedicineMassachusetts General HospitalBostonUSA

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