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From Synchronisation to Networks: Assessment of Functional Connectivity in the Brain

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Coordinated Activity in the Brain

Part of the book series: Springer Series in Computational Neuroscience ((NEUROSCI,volume 2))

Abstract

There is increasing evidence from basic research that statistical correlations between electroencephalographic (EEG) and magnetoencephalographic (MEG) rhythms recorded from different brain areas, either ‘at rest’ or during a specific task, contain a wealth of information on functional interactions between brain regions (Buzsaki, 2006; Varela et al., 2001). In fact, synchronisation of oscillatory brain activity in various frequency bands may be one of the key mechanisms used by the brain to integrate information processed in multiple specialised local brain areas. Many new signal analysis tools have become available in recent years to study such synchronisation patterns and their disruption in various neurological and neuropsychiatric diseases. The study of functional interaction patterns in the brain is even beginning to show some remarkable similarities between the brain and other complex networks, such as the Internet (Reijneveld et al., 2007). In this chapter, we give a brief introduction of concepts underlying functional connectivity and network analysis in EEG and MEG, the major tools that are used, their methodological aspects and shortcomings and the application to neurological disorders. The introduction is focused on presenting the concepts and ideas behind the methods; for technical details, we refer to more extensive review papers.

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  1. Department of Clinical Neurophysiology, VU University Medical Center, Amsterdam, The Netherlands

    Cornelis J. Stam

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  1. Inst. Medical Science, Dept. Paediatrics, University of Toronto, University Ave.555, Toronto , M5G 1X8, Canada

    Jose Luis Perez Velazquez

  2. Toronto Western Hospital, University Health Network, Bathurst Street 399, Toronto, M5T 2S8, Canada

    Richard Wennberg

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Stam, C.J. (2009). From Synchronisation to Networks: Assessment of Functional Connectivity in the Brain. In: Velazquez, J., Wennberg, R. (eds) Coordinated Activity in the Brain. Springer Series in Computational Neuroscience, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-0-387-93797-7_5

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