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Clinical Radiobiology and Physics

  • Gautam Prasad
  • Jean Pouliot
Chapter

Abstract

The Four Rs of Radiobiology (rationale for fractionation of radiation) Repair – refers to DNA repair in response to sublethal or potentially lethal radiation damage. Fractionation of radiation allows normal tissues time to repair. Reassortment – refers to radioresistant cells that synchronize into a more radiosensitive phase of the cell cycle after a fraction of radiation. Over multiple fractions, more and more cells are redistributed into these radiosensitive phases. Repopulation – refers to tumor cell proliferation during the course of radiation therapy. This can be problematic with very low dose rates (VLDRs) or prolonged treatment durations. Reoxygenation – refers to the importance of oxygen in mediating the cytotoxic effects of radiation due to free radical production. As normoxic tumor cells are killed with each fraction, formerly hypoxic cells become oxygenated.

Keywords

Planning Target Volume Mantle Cell Lymphoma Clinical Target Volume Gross Tumor Volume Radioactive Source 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Special thanks to Paula Petti and John Murnane for their Physics and Radiobiology teaching, which assisted in the preparation of this chapter.

Further Reading

  1. Hall EJ, Amato JC. Radiobiology for the Radiologist. 6th ed. Philadelphia: Lippincott Williams & Wilkins, 2006.Google Scholar
  2. ICRU. ICRU Report 50 – Prescribing, Recording and Reporting Photon Beam Therapy. Med Phys 21(6):833-4, 1994.Google Scholar
  3. ICRU. Prescribing, Recording and Reporting Photon Beam Therapy (Supplement to ICRU Report 50), ICRU Report 62. Bethesda: ICRU, 1999.Google Scholar
  4. ICRU. Prescribing, Recording and Reporting Photon Beam Therapy (Supplement to ICRU Report 50), ICRU Report 62. Bethesda: ICRU, 1999.Google Scholar
  5. Kahn, FM. The Physics of Radiation Therapy. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2003.Google Scholar

Copyright information

© Springer-Verlag New York 2010

Authors and Affiliations

  • Gautam Prasad
    • 1
  • Jean Pouliot
    • 2
  1. 1.Radiation OncologyUniversity of California San FranciscoSan FranciscoUSA
  2. 2.Physics Division, Radiation OncologyUniversity of California San FranciscoSan FranciscoUSA

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