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Cutaneous Lymphomas

  • Amy Gillis
  • Thomas T. Bui
  • Mack RoachIII
Chapter

Abstract

PEARLS Primary cutaneous lymphomas (PCL) are subdivided according to cell lineage. These include cutaneous B-cell lymphomas (CBCL) – 30% and cutaneous T-cell lymphomas (CTCL) – 70%. Overall, 1–1.5 new cases per 100,000/year. Annual age-adjusted incidence of CBCL was 4 per million; CTCL was 6 per million persons (Hoppe et al. 2004; Yahalom et al. 2004). Skin is the most common extranodal site of non-Hodgkin’s lymphoma (NHL), representing 2% of new cases of NHL. Affects older adults (55–60 years), 2:1 male predominance, blacks > whites. Hypothesized links with environmental factors or viral etiology not substantiated (de Jong et al. 2008) Presentation: skin lesions, but long natural history. Median time from skin lesion to diagnosis ∼5 years. Sézary cells: malignant T-cells. Sézary syndrome: erythroderma, lymphadenopathy, and Sézary cells in peripheral blood. Treatment should be tailored to specific subtype of PCL. Unlike other NHL’s, which use the Ann Arbor staging system, Mycosis fungoides/Sézary syndrome (MF/SS) uses a TNM staging system that correlates to prognosis (Kim et al. 2007; Horwitz et al. 2008). EORTC and WHO have classification schemes as well (Willemze et al. 2005; Golling et al. 2008).

Keywords

AJCC Cancer Stage Manual Regular Clinic Visit Patient Surface Primary Cutaneous Lymphoma Total Skin Electron Beam 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

REFERENCES

REFERENCES

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Further Readings

  1. Carter J, Zug K. Phototherapy for cutaneous T-cell lymphoma: Online survey and literature review. J Am Acad Dermatol. 2009;60:39-50.PubMedCrossRefGoogle Scholar
  2. de Jong D, Vasmel W, de Boer JP, et al. Anaplastic large-cell lymphoma in women with breast implants. JAMA. 2008;300(17):2030-2035.PubMedCrossRefGoogle Scholar
  3. Golling P, Cozzio A, Dummer R, et al. Primary cutaneous B-cell lymphomas – clinicopathological, prognostic and therapeutic characterisation of 54 cases according to the WHO-EORTC classification and the ISCL/EORTC TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sézary syndrome. Leuk Lymphoma. 2008;49(6):1094-1103.PubMedCrossRefGoogle Scholar
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  5. Horwitz S, Olsen E, Duvic M, et al. Review of the treatment of mycosis fungoides and Sézary syndrome: a stage-based approach. JNCCN. 2008;6:436-442.PubMedGoogle Scholar
  6. Kim Y, Willemze R, Pimpinelli N, et al. TNM classification system for cutaneous lymphomas other than mycosis fungoides and sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Research and Treatment of Cancer (EORTC). Blood. 2007;110:479-484.PubMedCrossRefGoogle Scholar
  7. National Comprehensive Cancer Network. Clinical Practice Guidelines in Oncology v1.2010: Multiple Myeloma. Available at http://www.nccn.org/professionals/physician_gls/PDF/nhl.pdf. Accessed on March 3, 2010.
  8. Yahalom J. Non-Hodgkin’s lymphoma. In: Leibel SA, Phillips TL, editors. Textbook of radiation oncology. 2nd ed. Philadelphia: Saunders; 2004. pp. 1393-1416.Google Scholar

Copyright information

© Springer-Verlag New York 2010

Authors and Affiliations

  • Amy Gillis
    • 1
  • Thomas T. Bui
    • 2
  • Mack RoachIII
    • 3
  1. 1.Radiation OncologyKaiser PermanenteSan FranciscoUSA
  2. 2.Radiation OncologyUniversity of California San FranciscoSan FranciscoUSA
  3. 3.Department of Radiation OncologyUniversity of California San FranciscoSan FranciscoUSA

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