Small Cell Lung Cancer

  • R. Scott Bermudez
  • Brian Missett
  • Daphne A. Haas-Kogan


SCLC accounts for 15–20% of lung cancer cases with decreasing incidence. Approximately 1/3 of patients present with limited stage disease and the remainder present with extensive stage disease. More than 95% of cases are associated with a history of tobacco exposure. Ten to 15% of patients present with brain metastases and 2 year incidence after chemo-RT is 50–80%. SCLC is the most common solid tumor associated with paraneoplastic syndromes: SIADH, ACTH production syndrome, and Eaton–Lambert syndrome. Histopathologic hallmarks include dense sheets of small, round to fusiform cells with scant cytoplasm, extensive necrosis, and a high mitotic rate. Pathologic subtypes (pure or classic, variant, and mixed) carry the same prognosis. Most important prognostic factors are stage and performance status.


Brain Metastasis Lung Cancer Case Prophylactic Cranial Irradiation High Mitotic Rate Common Solid Tumor 
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Copyright information

© Springer-Verlag New York 2010

Authors and Affiliations

  • R. Scott Bermudez
    • 1
  • Brian Missett
    • 2
  • Daphne A. Haas-Kogan
    • 1
  1. 1.Radiation OncologyUniversity of California San FranciscoSan FranciscoUSA
  2. 2.Radiation OncologyKaiser Permanente Santa ClaraSanta ClaraUSA

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