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Geriatric Patients with Epilepsy

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Book cover Handbook on the Neuropsychology of Epilepsy

Part of the book series: Clinical Handbooks in Neuropsychology ((CHNEURO))

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Abstract

Elderly patients with epilepsy share many characteristics with their younger cohort, but there are important differences between these groups that are relevant for the neuropsychologist working with older adults. Elderly patients with epilepsy have unique risk factors for comorbidities and complications that put them at increased risk of neurocognitive sequelae. The medical, cognitive, and psychosocial characteristics of this group often result in different referral questions and approaches for the development of clinical hypotheses, selection of tests, interpretation of results, and provision of recommendations.

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References

  • Acosta, I., Vale, F., Tatum, W. O., & Benbadis, S. R. (2008). Epilepsy surgery after age 60. Epilepsy and Behavior, 12, 324–325.

    PubMed  Google Scholar 

  • Arif, H., Buchsbaum, R., Pierro, J., Whalen, M., Sims, J., Resor, S. R., Jr., et al. (2010). Comparative effectiveness of 10 antiepileptic drugs in older adults with epilepsy. Archives of Neurology, 67(4), 408–415.

    PubMed  Google Scholar 

  • Baker, G. A., Jacoby, A., Buck, D., Brooks, J., Potts, P., & Chadwick, D. W. (2001). The quality of life of older people with epilepsy: Findings from a UK community study. Seizure, 10(2), 92–99.

    PubMed  Google Scholar 

  • Bambara, J. K., Griffith, H. R., Martin, R. C., Faught, E., Wadley, V. G., & Marson, D. C. (2007). Medical decision-making abilities in older adults with chronic partial epilepsy. Epilepsy and Behavior, 10(1), 63–68.

    PubMed  Google Scholar 

  • Barlow, D. H. (2001). Clinical handbook of psychological disorders. New York, NY: The Guilford Press.

    Google Scholar 

  • Baxendale, S. (1998). Amnesia in temporal lobectomy patients: Historical perspective and review. Seizure, 7(1), 15–24.

    PubMed  Google Scholar 

  • Beghi, M., Savica, R., Beghi, E., Nobili, A., & Garattini, L. (2009). Utilization and costs of antiepileptic drugs in the elderly: Still an unsolved issue. Drugs and Aging, 26(2), 157–168.

    PubMed  Google Scholar 

  • Bjorholt, P. G., Nakken, K. O., Rohme, K., & Hansen, H. (1990). Leisure time habits and physical fitness in adults with epilepsy. Epilepsia, 31(1), 83–87.

    PubMed  Google Scholar 

  • Breteler, M. M., de Groot, R. R., van Romunde, L. K., & Hofman, A. (1995). Risk of dementia in patients with Parkinson’s disease, epilepsy, and severe head trauma: A register-based follow-up study. American Journal of Epidemiology, 142, 1300–1305.

    PubMed  Google Scholar 

  • Breteler, M. M., van Duijn, C. M., Chandra, V., Fratiglioni, L., Graves, A. B., Heyman, A., et al. (1991). Medical history and the risk of Alzheimer’s disease: A collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. International Journal of Epidemiology, 20(Suppl 2), S36–S42.

    PubMed  Google Scholar 

  • Brodie, M. J., & Kwan, P. (2005). Epilepsy in elderly people. BMJ, 331(7528), 1317–1322.

    PubMed Central  PubMed  Google Scholar 

  • Brodie, M. J., Overstall, P. W., & Giorgi, L. (1999). Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. The UK Lamotrigine Elderly Study Group. Epilepsy Research, 37(1), 81–87.

    PubMed  Google Scholar 

  • Brodie, M. J., & Stephen, L. J. (2007). Outcomes in elderly patients with newly diagnosed and treated epilepsy. International Review of Neurobiology, 81, 253–263.

    PubMed  Google Scholar 

  • Caramelli, P., & Castro, L. H. (2005). Dementia associated with epilepsy. International Psychogeriatrics, 17(Suppl 1), S195–S206.

    PubMed  Google Scholar 

  • Carney, R. M., Freedland, K. E., Eisen, S. A., Rich, M. W., & Jaffe, A. S. (1995). Major depression and medication adherence in elderly patients with coronary artery disease. Health Psychology, 14(1), 88–90.

    PubMed  Google Scholar 

  • Carter, M. D., Weaver, D. F., Joudrey, H. R., Carter, A. O., & Rockwood, K. (2007). Epilepsy and antiepileptic drug use in elderly people as risk factors for dementia. Journal of Neurological Sciences, 252(2), 169–172.

    Google Scholar 

  • Cleary, P., Shorvon, S., & Tallis, R. (2004). Late-onset seizures as a predictor of subsequent stroke. Lancet, 363(9416), 1184–1186.

    PubMed  Google Scholar 

  • Cloyd, J., Hauser, W. A., Towne, A., Ramsay, R., Mattson, R., Gilliam, F., et al. (2006). Epidemiological and medical aspects of epilepsy in the elderly. Epilepsy Research, 68(Suppl 1), S39–S48.

    PubMed  Google Scholar 

  • Cramer, J. A., Perrine, K., Devinsky, O., Bryant-Comstock, L., Meador, K., & Hermann, B. (1998). Development and cross-cultural translations of a 31-item quality of life in epilepsy inventory. Epilepsia, 39(1), 81–88.

    PubMed  Google Scholar 

  • de la Court, A., Breteler, M. M. B., Meinardi, H., Hauser, W. A., & Hofman, A. (1996). Prevalence of epilepsy in the elderly: The Rotterdam study. Epilepsia, 37(2), 141–147.

    PubMed  Google Scholar 

  • DeLorenzo, R. J., Hauser, W. A., Towne, A. R., Boggs, J. G., Pellock, J. M., Penberthy, L., et al. (1996). A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology, 46(4), 1029–1035.

    PubMed  Google Scholar 

  • Devinsky, O., Vickrey, B. G., Cramer, J., Perrine, K., Hermann, B., Meador, K., et al. (1995). Development of the quality of life in epilepsy inventory. Epilepsia, 36(11), 1089–1104.

    PubMed  Google Scholar 

  • Donnell, A. J., Pliskin, N., Holdnack, J., Axelrod, B., & Randolph, C. (2007). Rapidly-administered short forms of the Wechsler Adult Intelligence Scale-3rd edition. Archives of Clinical Neuropsychology, 22(8), 917–924.

    PubMed  Google Scholar 

  • Drury, I., & Beydoun, A. (1998). Interictal epileptiform activity in elderly patients with epilepsy. Electroencephalography and Clinical Neurophysiology, 106(4), 369–373.

    PubMed  Google Scholar 

  • Ferrendelli, J. A., French, J., Leppik, I., Morrell, M. J., Herbeuval, A., Han, J., et al. (2003). Use of levetiracetam in a population of patients aged 65 years and older: A subset analysis of the KEEPER trial. Epilepsy and Behavior, 4(6), 702–709.

    PubMed  Google Scholar 

  • Fillit, H. M., Butler, R. N., O’Connell, A. W., Albert, M. S., Birren, J. E., Cotman, C. W., et al. (2002). Achieving and maintaining cognitive vitality with aging. Mayo Clinic Proceedings, 77(7), 681–696.

    PubMed  Google Scholar 

  • Forstl, H., Burns, A., Levy, R., Cairns, N., Luthert, P., & Lantos, P. (1992). Neurologic signs in Alzheimer’s disease. Results of a prospective clinical and neuropathologic study. Archives of Neurology, 49(10), 1038–1042.

    PubMed  Google Scholar 

  • Frey, M. (2007). Psychiatric complications of epilepsy in the geriatric patient: Diagnostic and treatment considerations. In A. B. Ettinger & A. M. Kanner (Eds.), Psychiatric issues in epilepsy: A practical guide (2nd ed.). Philadelphia, PA: Lippincott Williams & Wilkins.

    Google Scholar 

  • Gaitatzis, A., Carroll, K., Majeed, A., & W Sander, J. (2004). The epidemiology of the comorbidity of epilepsy in the general population. Epilepsia, 45(12), 1613–1622.

    PubMed  Google Scholar 

  • Gilliam, F. G., Barry, J. J., Hermann, B. P., Meador, K. J., Vahle, V., & Kanner, A. M. (2006). Rapid detection of major depression in epilepsy: A multicentre study. Lancet Neurology, 5(5), 399–405.

    Google Scholar 

  • Giorgi, L., Gomez, G., O’Neill, F., Hammer, A. E., & Risner, M. (2001). The tolerability of lamotrigine in elderly patients with epilepsy. Drugs and Aging, 18(8), 621–630.

    PubMed  Google Scholar 

  • Glauser, T., Ben-Menachem, E., Bourgeois, B., Cnaan, A., Chadwick, D., Guerreiro, C., et al. (2006). ILAE treatment guidelines: Evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia, 47(7), 1094–1120.

    PubMed  Google Scholar 

  • Glosser, G., Cole, L. C., French, J. A., Saykin, A. J., & Sperling, M. R. (1997). Predictors of intellectual performance in adults with intractable temporal lobe epilepsy. Journal of International Neuropsychological Society, 3(3), 252–259.

    Google Scholar 

  • Griffith, H. R., Martin, R. C., Bambara, J. K., Faught, E., Vogtle, L. K., & Marson, D. C. (2007). Cognitive functioning over 3 years in community dwelling older adults with chronic partial epilepsy. Epilepsy Research, 74(2–3), 91–96.

    PubMed  Google Scholar 

  • Griffith, H. R., Martin, R. C., Bambara, J. K., Marson, D. C., & Faught, E. (2006). Older adults with epilepsy demonstrate cognitive impairments compared with patients with amnestic mild cognitive impairment. Epilepsy and Behavior, 8(1), 161–168.

    PubMed  Google Scholar 

  • Grivas, A., Schramm, J., Kral, T., von Lehe, M., Helmstaedter, C., Elger, C. E., et al. (2006). Surgical treatment for refractory temporal lobe epilepsy in the elderly: Seizure outcome and neuropsychological sequels compared with a younger cohort. Epilepsia, 47, 1364–1372.

    PubMed  Google Scholar 

  • Hamed, S. A., & Nabeshima, T. (2005). The high atherosclerotic risk among epileptics: The atheroprotective role of multivitamins. Journal of Pharmacological Sciences, 98(4), 340–353.

    PubMed  Google Scholar 

  • Hasher, L., Chung, C., May, C. P., & Foong, N. (2002). Age, time of testing, and proactive interference. Canadian Journal of Experimental Psychology, 56(3), 200–207.

    PubMed Central  PubMed  Google Scholar 

  • Hauser, W. A. (1992). Seizure disorders: The changes with age. Epilepsia, 33(Suppl 4), S6–S14.

    PubMed  Google Scholar 

  • Hauser, W. A., Annegers, J. F., & Kurland, L. T. (1991). Prevalence of epilepsy in Rochester, Minnesota: 1940–1980. Epilepsia, 32(4), 429–445.

    PubMed  Google Scholar 

  • Hauser, W. A., Annegers, J. F., & Kurland, L. T. (1993). Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935–1984. Epilepsia, 34, 453–468.

    PubMed  Google Scholar 

  • Hauser, W. A., Annegers, J. F., & Rocca, W. A. (1996). Descriptive epidemiology of epilepsy: Contributions of population-based studies from Rochester, Minnesota. Mayo Clinic Proceedings, 71(6), 576–586.

    PubMed  Google Scholar 

  • Hauser, W. A., Morris, M. L., Heston, L. L., & Anderson, V. E. (1986). Seizures and myoclonus in patients with Alzheimer’s disease. Neurology, 36(9), 1226–1230.

    PubMed  Google Scholar 

  • Haut, S. R., Katz, M., Masur, J., & Lipton, R. B. (2009). Seizures in the elderly: Impact on mental status, mood, and sleep. Epilepsy and Behavior, 14(3), 540–544.

    PubMed Central  PubMed  Google Scholar 

  • Heaton, R. K., Miller, S. W., Taylor, M. J., & Grant, I. (2008). Revised comprehensive norms for an expanded Halstead-Reitan battery: Demographically adjusted neuropsychological norms for African American and Caucasian adults. Lutz, FL: PAR.

    Google Scholar 

  • Helmstaedter, C., & Elger, C. E. (2009). Chronic temporal lobe epilepsy: A neurodevelopmental or progressively dementing disease? Brain, 132(Pt 10), 2822–2830.

    PubMed  Google Scholar 

  • Helmstaedter, C., Kurthen, M., Lux, S., Reuber, M., & Elger, C. E. (2003). Chronic epilepsy and cognition: A longitudinal study in temporal lobe epilepsy. Annals of Neurology, 54(4), 425–432.

    PubMed  Google Scholar 

  • Helmstaedter, C., Reuber, M., & Elger, C. C. (2002a). Interaction of cognitive aging and memory deficits related to epilepsy surgery. Annals of Neurology, 52(1), 89–94.

    PubMed  Google Scholar 

  • Helmstaedter, C., Reuber, M., & Elger, C. C. E. (2002b). Interaction of cognitive aging and memory deficits related to epilepsy surgery. Annals of Neurology, 52, 89–94.

    PubMed  Google Scholar 

  • Hermann, B., & Seidenberg, M. (2002). Neuropsychology and temporal lobe epilepsy. CNS Spectrums, 7(5), 343–348.

    PubMed  Google Scholar 

  • Hermann, B. P., Seidenberg, M., Dow, C., Jones, J., Rutecki, P., Bhattacharya, A., et al. (2006a). Cognitive prognosis in chronic temporal lobe epilepsy. Annals of Neurology, 60(1), 80–87.

    PubMed  Google Scholar 

  • Hermann, B. P., Seidenberg, M., Dow, C., Jones, J., Rutecki, P., Bhattacharya, A., et al. (2006b). Cognitive prognosis in chronic temporal lobe epilepsy. Annals of Neurology, 60, 80–87.

    PubMed  Google Scholar 

  • Hermann, B., Seidenberg, M., Sager, M., Carlsson, C., Gidal, B., Sheth, R., et al. (2008). Growing old with epilepsy: The neglected issue of cognitive and brain health in aging and elder persons with chronic epilepsy. Epilepsia, 49, 731–740.

    PubMed Central  PubMed  Google Scholar 

  • Hermann, B. P., Seidenberg, M., & Bell, B. (2002). The neurodevelopmental impact of childhood onset temporal lobe epilepsy on brain structure and function and the risk of progressive cognitive effects. Progress in Brain Research, 135, 429–438.

    PubMed  Google Scholar 

  • Hermann, B., Seidenberg, M., & Jones, J. (2008). The neurobehavioural comorbidities of epilepsy: Can a natural history be developed? Lancet Neurology, 7(2), 151–160.

    Google Scholar 

  • Hesdorffer, D. C., Hauser, W. A., Annegers, J. F., Kokmen, E., & Rocca, W. A. (1996). Dementia and adult-onset unprovoked seizures. Neurology, 46(3), 727–730.

    PubMed  Google Scholar 

  • Isojarvi, J. I., Rattya, J., Myllyla, V. V., Knip, M., Koivunen, R., Pakarinen, A. J., et al. (1998). Valproate, lamotrigine, and insulin-mediated risks in women with epilepsy. Annals of Neurology, 43(4), 446–451.

    PubMed  Google Scholar 

  • Ivnik, R. J., Malec, J. F., Smith, G. E., Tangalos, E. G., & Petersen, R. C. (1996). Neuropsychological tests’ norms above age 55: COWAT, BNT, MAE Token, WRAT-R Reading, AMNART, STROOP, TMT, and JLO. The Clinical Neuropsychologist, 10, 262–278.

    Google Scholar 

  • Kutluay, E., McCague, K., D’Souza, J., & Beydoun, A. (2003). Safety and tolerability of oxcarbazepine in elderly patients with epilepsy. Epilepsy and Behavior, 4(2), 175–180.

    PubMed  Google Scholar 

  • Kwan, P., & Brodie, M. J. (2001). Neuropsychological effects of epilepsy and antiepileptic drugs. Lancet, 357(9251), 216–222.

    PubMed  Google Scholar 

  • Laccheo, I., Ablah, E., Heinrichs, R., Sadler, T., Baade, L., & Liow, K. (2008). Assessment of quality of life among the elderly with epilepsy. Epilepsy and Behavior, 12(2), 257–261.

    PubMed  Google Scholar 

  • Lozsadi, D. A., & Larner, A. J. (2006). Prevalence and causes of seizures at the time of diagnosis of probable Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 22(2), 121–124.

    PubMed  Google Scholar 

  • Lucas, J. A., Ivnik, R. J., Willis, F. B., Ferman, T. J., Smith, G. E., Parfitt, F. C., et al. (2005). Mayo’s Older African Americans Normative Studies: Normative data for commonly used clinical neuropsychological measures. The Clinical Neuropsychologist, 19(2), 162–183.

    PubMed  Google Scholar 

  • Luef, G. J., Waldmann, M., Sturm, W., Naser, A., Trinka, E., Unterberger, I., et al. (2004). Valproate therapy and nonalcoholic fatty liver disease. Annals of Neurology, 55(5), 729–732.

    PubMed  Google Scholar 

  • Mackenzie, I. R., McLachlan, R. S., Kubu, C. S., & Miller, L. A. (1996). Prospective neuropsychological assessment of nondemented patients with biopsy proven senile plaques. Neurology, 46(2), 425–429.

    PubMed  Google Scholar 

  • Mackenzie, I. R., & Miller, L. A. (1994). Senile plaques in temporal lobe epilepsy. Acta Neuropathologica (Berlin), 87, 504–510.

    Google Scholar 

  • Marchiori, P. E., Yasuda, N., Azevedo, H. C., Orfao, M., Callegaro, D., Yamamoto, F. I., et al. (1996). Creutzfeldt-Jakob disease. A survey of 14 patients. Arquivos de Neuro-Psiquiatria, 54(4), 577–583.

    PubMed  Google Scholar 

  • Martin, R. C., Griffith, H. R., Faught, E., Gilliam, F., Mackey, M., & Vogtle, L. (2005). Cognitive functioning in community dwelling older adults with chronic partial epilepsy. Epilepsia, 46, 298–303.

    PubMed  Google Scholar 

  • Martin, R., Vogtle, L., Gilliam, F., & Faught, E. (2005). What are the concerns of older adults living with epilepsy? Epilepsy and Behavior, 7(2), 297–300.

    PubMed  Google Scholar 

  • Massimiliano, B., Rodolfo, S., Beghi, E., Nobili, A., & Garattini, L. (2009). Utilization and costs of antiepileptic drugs in the elderly. Drugs and Aging, 26(2), 157–168.

    Google Scholar 

  • Mauri Llerda, J. A., Tejero, C., Mercade, J. M., Padro, L. L., & Salas Puig, J. (2005). Lamotrigine and epilepsy in the elderly: Observational study of low-dose monotherapy. International Journal of Clinical Practice, 59(6), 651–654.

    PubMed  Google Scholar 

  • McAreavey, M. J., Ballinger, B. R., & Fenton, G. W. (1992). Epileptic seizures in elderly patients with dementia. Epilepsia, 33(4), 657–660.

    PubMed  Google Scholar 

  • McBride, A. E., Shih, T. T., & Hirsch, L. J. (2002). Video-EEG monitoring in the elderly: A review of 94 patients. Epilepsia, 43(2), 165–169.

    PubMed  Google Scholar 

  • McLaughlin, D. P., Pachana, N. A., & McFarland, K. (2008). Stigma, seizure frequency and quality of life: The impact of epilepsy in late adulthood. Seizure, 17(3), 281–287.

    PubMed  Google Scholar 

  • Mendez, M. F., Catanzaro, P., Doss, R. C., ARguello, R., & Frey, W. H., II. (1994). Seizures in Alzheimer’s disease: Clinicopathologic study. Journal of Geriatric Psychiatry and Neurology, 7(4), 230–233.

    PubMed  Google Scholar 

  • Mendez, M., & Lim, G. (2003). Seizures in elderly patients with dementia: Epidemiology and management. Drugs and Aging, 20(11), 791–803.

    PubMed  Google Scholar 

  • Mohanraj, R., & Brodie, M. J. (2006). Diagnosing refractory epilepsy: Response to sequential treatment schedules. European Journal of Neurology, 13(3), 277–282.

    PubMed  Google Scholar 

  • Moller, J. T., Cluitmans, P., Rasmussen, L. S., Houx, P., Rasmussen, H., Canet, J., et al. (1998). Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction. Lancet, 351(9106), 857–861.

    PubMed  Google Scholar 

  • Monk, T. G., Weldon, B. C., Garvan, C. W., Dede, D. E., van der Aa, M. T., Heilman, K. M., et al. (2008). Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology, 108(1), 18–30.

    PubMed  Google Scholar 

  • Nakken, K. O. (1999). Physical exercise in outpatients with epilepsy. Epilepsia, 40(5), 643–651.

    PubMed  Google Scholar 

  • Ono, H., Sakamoto, A., Eguchi, T., Fujita, N., Nomura, S., Ueda, H., et al. (1997). Plasma total homocysteine concentrations in epileptic patients taking anticonvulsants. Metabolism, 46(8), 959–962.

    PubMed  Google Scholar 

  • Oyegbile, T. O., Dow, C., Jones, J., Bell, B., Rutecki, P., Sheth, R., et al. (2004). The nature and course of neuropsychological morbidity in chronic temporal lobe epilepsy. Neurology, 62(10), 1736–1742.

    PubMed  Google Scholar 

  • Piazzini, A., Canevini, M. P., Turner, K., Chifari, R., & Canger, R. (2006). Elderly people and epilepsy: Cognitive function. Epilepsia, 47(Suppl. 5), 82–84.

    PubMed  Google Scholar 

  • Pugh, M. J., Copeland, L. A., Zeber, J. E., Cramer, J. A., Amuan, M. E., Cavazos, J. E., et al. (2005). The impact of epilepsy on health status among younger and older adults. Epilepsia, 46(11), 1820–1827.

    PubMed  Google Scholar 

  • Pylvanen, V., Knip, M., Pakarinen, A. J., Turkka, J., Kotila, M., Rattya, J., et al. (2003). Fasting serum insulin and lipid levels in men with epilepsy. Neurology, 60(4), 571–574.

    PubMed  Google Scholar 

  • Ramsay, R. E., & Pryor, F. (2000). Epilepsy in the elderly. Neurology, 55(5 Suppl 1), S9–S14.

    PubMed  Google Scholar 

  • Ramsay, R. E., Rowan, A. J., & Pryor, F. M. (2004). Special considerations in treating the elderly patient with epilepsy. Neurology, 62(Suppl 2), S24–S29.

    PubMed  Google Scholar 

  • Rausch, R., Kraemer, S., Pietras, C. J., Le, M., Vickrey, B. G., & Passaro, E. A. (2003). Early and late cognitive changes following temporal lobe surgery for epilepsy. Neurology, 60(6), 951–959.

    PubMed  Google Scholar 

  • Rowan, A. J., Ramsay, R. E., Collins, J. F., Pryor, F., Boardman, K. D., Uthman, B. M., et al. (2005). New onset geriatric epilepsy: A randomized study of gabapentin, lamotrigine, and carbamazepine. Neurology, 64(11), 1868–1873.

    PubMed  Google Scholar 

  • Saetre, E., Perucca, E., Isojärvi, J., & Gjerstad, L. (2007). An international multicenter randomized double-blind controlled trial of lamotrigine and sustained-release carbamazepine in the treatment of newly diagnosed epilepsy in the elderly. Epilepsia, 48(7), 1292–1302.

    PubMed  Google Scholar 

  • Schwaninger, M., Ringleb, P., Annecke, A., Winter, R., Kohl, B., Werle, E., et al. (2000). Elevated plasma concentrations of lipoprotein(a) in medicated epileptic patients. Journal of Neurology, 247(9), 687–690.

    PubMed  Google Scholar 

  • Seaetre, E., Abdelnoor, M., Perucca, E., Taubøll, E., Isojärvi, J., & Gjerstad, L. (2010). Antiepileptic drugs and quality of life in the elderly: Results from a randomized double-blind trial of carbamazepine and lamotrigine in patients with onset of epilepsy in old age. Epilepsy and Behavior, 17(3), 395–401.

    Google Scholar 

  • Sheorajpanday, R. V., & De Deyn, P. P. (2007). Epileptic fits and epilepsy in the elderly: General reflections, specific issues and therapeutic implications. Clinical Neurology and Neurosurgery, 109(9), 727–743.

    PubMed  Google Scholar 

  • Sheth, R. D. (2004). Metabolic concerns associated with antiepileptic medications. Neurology, 63(10 Suppl 4), S24–S29.

    PubMed  Google Scholar 

  • Sheth, R. D., Drazkowski, J. F., Sirven, J. I., Gidal, B. E., & Hermann, B. P. (2006). Protracted ictal confusion in elderly patients. Archives of Neurology, 63(4), 529–532.

    PubMed  Google Scholar 

  • Sirven, J. I., Malamut, B. L., O’Connor, M. J., & Sperling, M. R. (2000). Temporal lobectomy outcome in older versus younger adults. Neurology, 54, 2166–2169.

    PubMed  Google Scholar 

  • Smith, G., & Rush, B. (2006). Normal aging and mild cognitive impairment. In D. K. Attix & K. A. Welsh-Bohmer (Eds.), Geriatric neuropsychology. New York, NY: Guilford.

    Google Scholar 

  • Sommer, B. R., & Fenn, H. H. (2010). Review of topiramate for the treatment of epilepsy in elderly patients. Clinical Interventions in Aging, 5, 89–99.

    PubMed Central  PubMed  Google Scholar 

  • Strauss, E., Loring, D., Chelune, G., Hunter, M., Hermann, B., Perrine, K., et al. (1995). Predicting cognitive impairment in epilepsy: Findings from the Bozeman epilepsy consortium. Journal of Clinical and Experimental Neuropsychology, 17(6), 909–917.

    PubMed  Google Scholar 

  • Strober, L. B., & Arnett, P. A. (2009). Assessment of depression in three medically ill, elderly populations: Alzheimer’s disease, Parkinson’s disease, and stroke. The Clinical Neuropsychologist, 23(2), 205–230.

    PubMed  Google Scholar 

  • Tellez-Zenteno, J. F., Matijevic, S., & Wiebe, S. (2005). Somatic comorbidity of epilepsy in the general population in Canada. Epilepsia, 46(12), 1955–1962.

    PubMed  Google Scholar 

  • Thompson, P. J., & Duncan, J. S. (2005). Cognitive decline in severe intractable epilepsy. Epilepsia, 46(11), 1780–1787.

    PubMed  Google Scholar 

  • Thorvaldsen, P., Asplund, K., Kuulasmaa, K., Rajakangas, A. M., & Schroll, M. (1995). Stroke incidence, case fatality, and mortality in the WHO MONICA project. World Health Organization Monitoring Trends and Determinants in Cardiovascular Disease. Stroke, 26(3), 361–367.

    PubMed  Google Scholar 

  • Tinuper, P., Provini, F., Marini, C., Cerullo, A., Plazzi, G., Avoni, P., et al. (1996). Partial epilepsy of long duration: Changing semiology with age. Epilepsia, 37(2), 162–164.

    PubMed  Google Scholar 

  • Van Cott, A. C. (2002). Epilepsy and EEG in the elderly. Epilepsia, 43(Suppl 3), 94–102.

    PubMed  Google Scholar 

  • Verrotti, A., Basciani, F., Trotta, D., Greco, R., Morgese, G., & Chiarelli, F. (2001). Effect of anticonvulsant drugs on interleukins-1, -2 and -6 and monocyte chemoattractant protein-1. Clinical and Experimental Medicine, 1(3), 133–136.

    PubMed  Google Scholar 

  • Vezzani, A., & Granata, T. (2005). Brain inflammation in epilepsy: Experimental and clinical evidence. Epilepsia, 46(11), 1724–1743.

    PubMed  Google Scholar 

  • Volicer, L., Smith, S., & Volicer, B. J. (1995). Effect of seizures on progression of dementia of the Alzheimer type. Dementia, 6(5), 258–263.

    PubMed  Google Scholar 

  • Wallace, H., Shorvon, S., & Tallis, R. (1998). Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2 052 922 and age-specific fertility rates of women with epilepsy. Lancet, 352, 1970–1973.

    PubMed  Google Scholar 

  • Weiner, M. F., Hynan, L. S., Parikh, B., Zaki, N., White, C. L., III, Bigio, E. H., et al. (2003). Can Alzheimer’s disease and dementias with Lewy bodies be distinguished clinically? Journal of Geriatric Psychiatry and Neurology, 16(4), 245–250.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Aurora Health Care, 215 W. Washington Street, Grafton, WI, 53024, USA

    Jessica Chapin

  2. Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue/P57, Cleveland, OH, 44195, USA

    Richard Naugle Ph.D., A.B.P.P.

Authors
  1. Jessica Chapin
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  2. Richard Naugle Ph.D., A.B.P.P.
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Correspondence to Jessica Chapin .

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Editors and Affiliations

  1. Dept. Neurosurgery, New York University School of Medicine, New York, New York, USA

    William B. Barr

  2. Dept. Neurosurgery, New York University School of Medicine, New York, New York, USA

    Chris Morrison

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Chapin, J., Naugle, R. (2015). Geriatric Patients with Epilepsy. In: Barr, W., Morrison, C. (eds) Handbook on the Neuropsychology of Epilepsy. Clinical Handbooks in Neuropsychology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92826-5_3

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