Normal Distribution, Variants, Pitfalls, and Artifacts

  • Ora Israel
  • Dominique Delbeke


18F-FDG is an analog of glucose and therefore has a similar biodistribution. 18F-FDG enters the cells by the same transport mechanism as glucose and is intracellularly phosphorylated by a hexokinase into 18F-FDG-6-phosphate (18F-FDG-6-P). As an indicator of glucose metabolism, 18F-FDG is not taken up only by malignant cells. In tissues with a low concentration of glucose-6-phosphatase, such as the brain, the myocardium, and most malignant cells, 18F-FDG-6-P does not follow further enzymatic pathways and accumulates proportionally to the glycolytic cellular rate.


Positron Emission Tomography Single Photon Emission Compute Tomography Brown Adipose Tissue Tracer Uptake Papillary Thyroid Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Nuclear MedicineRambam Health Care CampusHaifaIsrael
  2. 2.R. Rappaport School of Medicine, TechnionIsrael Institute of TechnologyHaifaIsrael
  3. 3.Department of Radiology and Radiological SciencesVanderbilt University Medical CenterNashvilleUSA

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