Introduction to Biophysics of DNA–Protein Interactions: From Single Molecules to Biological Systems

  • Mark C. Williams
  • L. James MaherIII
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)


The field of biophysics grows as new methods are applied to increasingly complex biological problems. For example, the field of single molecule biophysics has made new contributions to many areas of biology, from molecular to cellular levels. These insights enhance our quantitative understanding of biology. Recent studies that combine in vitro bulk biochemical methods, single molecule experiments, and in vivo approaches to molecular interactions have advanced many areas of biology. Particularly relevant illustrative examples are provided by the field of DNA–protein interactions. This book focus on some of these examples, involving application of in vitro bulk solution methods to probe interactions at the molecular level, single molecule methods, and in vivo measurements in the same systems. The book ­presents an overview of modern quantitative methods used for studying DNA–protein interactions, and displays the various levels of complexity involved in studying these interactions in biological systems. These chapters should therefore be of interest to all workers in the field of DNA–protein interactions.


Single Molecule Replication Fork Single Molecule Experiment Bacteriophage Replication Single Molecule Force Spectroscopy 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of PhysicsNortheastern UniversityBostonUSA
  2. 2.Department of Biochemistry and Molecular BiologyMayo Clinic College of MedicineRochesterUSA

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