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Stress Responses of Lactococcus lactis

  • Juan Zhang
  • Chongde Wu
  • Feng Xue
  • Guocheng Du
  • Jian Chen
Chapter
Part of the Food Microbiology and Food Safety book series (FMFS)

Abstract

Lactococcus lactis is a Gram-positive bacterium widely used as a starter culture in the food industry due to its health-promoting and nutritional properties. However, L. lactis, similar to other lactic acid bacteria, encounters various stress conditions both during industrial processes and in the gastrointestinal tract. In response to environmental stresses, L. lactis employs numerous mechanisms to survive under stressful conditions. In this chapter, the stress responses of L. lactis, including alterations in the metabolic activities and energy state as well as the intracellular stress signals are summarized and discussed. In general, environmental stresses result in decreased glycolytic activity and in shifts of the metabolic pathways to counteract the harsh environment encountered. In addition, the intracellular stress-response signals such as the maintenance of intracellular pH homeostasis and the accumulation of specific intermediates are elucidated. Finally, we summarize the cross-protection phenomenon in L. lactis, which leads to increased stress resistance by pre-exposure of the cells to a mild stress. We believe that by addressing the overall stress responses of L. lactis, we are contributing to a deeper understanding of the tolerance mechanisms in this microorganism to environmental stresses that may provide new strategies to enhance the industrial utility of this species.

Keywords

Lactic Acid Bacterium Cholic Acid Glycine Betaine Proton Motive Force Acid Tolerance Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Preparation of this chapter was supported in part by a grant from the Major Program of National Natural Science Foundation of China (No. 20836003) and the National Natural Science Foundation of China (No. 30900013). We also thank Chongde Wu and Feng Xue for their numerous contributions to this work.

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.School of BiotechnologyJiangnan UniversityWuxiChina
  2. 2.The Key Laboratory of Industrial Biotechnology, Ministry of EducationWuxiChina
  3. 3.State Key Laboratory of Food Science and TechnologyJiangnan UniversityWuxiChina

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