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Nectins and Nectin-Like Molecules in the Nervous System

  • Hideru Togashi
  • Hisakazu Ogita
  • Yoshimi TakaiEmail author
Chapter
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Abstract

Nectins and nectin-like molecules (Necls) are immunoglobulin-like transmembrane cell-adhesion molecules that are expressed in various cell types. Nectins form homo- or hetero-trans-dimers in a Ca2+-independent manner, causing cell–cell adhesion. Their heterotypic binding is much stronger than their homophilic binding. In epithelial cells in culture, cell–cell adhesion complexes are formed by nectins first and then cadherins are recruited to the nectin-based cell–cell adhesion sites to cooperatively form adherens junctions (AJs). Recent studies have revealed that nectins in cooperation with cadherins are also involved in the formation of synapses. In this chapter, we first describe the roles and modes of action of nectins and Necls in epithelial cells and fibroblasts and then in the formation and remodeling of synapses.

Keywords

Nectin Cadherin Immunoglobulin Adherens junctions Puncta adherentia junctions Synapse 
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References

  1. Abercrombie M and Heaysman JE (1953) Observations on the social behaviour of cells in tissue culture. I. Speed of movement of chick heart fibroblasts in relation to their mutual contacts. Exp Cell Res 5:111–131CrossRefPubMedGoogle Scholar
  2. Allison DW, Gelfand VI, Spector I et al. (1998) Role of actin in anchoring postsynaptic receptors in cultured hippocampal neurons: differential attachment of NMDA versus AMPA receptors. J Neurosci 18:2423–2436PubMedGoogle Scholar
  3. Amano H, Ikeda W, Kawano S et al. (2008) Interaction and localization of Necl-5 and PDGF receptor beta at the leading edges of moving NIH3T3 cells: Implications for directional cell movement. Genes Cells 13:269–284CrossRefPubMedGoogle Scholar
  4. Asada M, Irie K, Morimoto K et al. (2003) ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions. J Biol Chem 278:4103–4111CrossRefPubMedGoogle Scholar
  5. Biederer T, Sara Y, Mozhayeva M et al. (2002) SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science 297:1525–1531CrossRefPubMedGoogle Scholar
  6. Bockers TM, Mameza MG, Kreutz MR et al. (2001) Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin. J Biol Chem 276:40104–40112CrossRefPubMedGoogle Scholar
  7. Boles KS, Barchet W, Diacovo T et al. (2005) The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. Blood 106:779–786CrossRefPubMedGoogle Scholar
  8. Bozdagi O, Valcin M, Poskanzer K et al. (2004) Temporally distinct demands for classic cadherins in synapse formation and maturation. Mol Cell Neurosci 27:509–521CrossRefPubMedGoogle Scholar
  9. Carlisle HJ and Kennedy MB (2005) Spine architecture and synaptic plasticity. Trends Neurosci 28:182–187CrossRefPubMedGoogle Scholar
  10. Chen L, Xie X, Zhang X et al. (2003) The expression, regulation and adhesion function of a novel CD molecule, CD226, on human endothelial cells. Life Sci 73:2373–2382CrossRefPubMedGoogle Scholar
  11. Di Paolo G, Pellegrini L, Letinic K et al. (2002) Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. Nature 420:85–89CrossRefPubMedGoogle Scholar
  12. Fiala JC, Spacek J and Harris KM (2002) Dendritic spine pathology: cause or consequence of neurological disorders? Brain Res Brain Res Rev 39:29–54CrossRefPubMedGoogle Scholar
  13. Fischer M, Kaech S, Wagner U et al. (2000) Glutamate receptors regulate actin-based plasticity in dendritic spines. Nat Neurosci 3:887–894CrossRefPubMedGoogle Scholar
  14. Fuchs A, Cella M, Giurisato E et al. (2004) Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J Immunol 172:3994–3998PubMedGoogle Scholar
  15. Fujito T, Ikeda W, Kakunaga S et al. (2005) Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3. J Cell Biol 171:165–173CrossRefPubMedGoogle Scholar
  16. Fukuhara T, Shimizu K, Kawakatsu T et al. (2004) Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG. J Cell Biol 166:393–405CrossRefPubMedGoogle Scholar
  17. Geinisman Y, de Toledo-Morrell L, Morrell F et al. (1993) Structural synaptic correlate of long-term potentiation: formation of axospinous synapses with multiple, completely partitioned transmission zones. Hippocampus 3:435–445CrossRefPubMedGoogle Scholar
  18. Geraghty RJ, Krummenacher C, Cohen GH et al. (1998) Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Science 280:1618–1620CrossRefPubMedGoogle Scholar
  19. Gerke V and Moss SE (2002) Annexins: from structure to function. Physiol Rev 82:331–371PubMedGoogle Scholar
  20. Gumbiner B and Simons K (1986) A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide. J Cell Biol 102:457–468CrossRefPubMedGoogle Scholar
  21. Gumbiner B, Stevenson B and Grimaldi A (1988) The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex. J Cell Biol 107:1575–1587CrossRefPubMedGoogle Scholar
  22. Gumbiner BM (1996) Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 84:345–357CrossRefPubMedGoogle Scholar
  23. Hering H and Sheng M (2003) Activity-dependent redistribution and essential role of cortactin in dendritic spine morphogenesis. J Neurosci 23:11759–11769PubMedGoogle Scholar
  24. Hirao K, Hata Y, Ide N et al. (1998) A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins. J Biol Chem 273:21105–21110CrossRefPubMedGoogle Scholar
  25. Honda T, Sakisaka T, Yamada T et al. (2006) Involvement of nectins in the formation of puncta adherentia junctions and the mossy fiber trajectory in the mouse hippocampus. Mol Cell Neurosci 31:315–325CrossRefPubMedGoogle Scholar
  26. Honda T, Shimizu K, Kawakatsu T et al. (2003) Cdc42 and Rac small G proteins activated by trans-interactions of nectins are involved in activation of c-Jun N-terminal kinase, but not in association of nectins and cadherin to form adherens junctions, in fibroblasts. Genes Cells 8:481–491CrossRefPubMedGoogle Scholar
  27. Honjo Y, Nakagawa S and Takeichi M (2000) Blockade of cadherin-6B activity perturbs the distribution of PSD-95 family proteins in retinal neurones. Genes Cells 5:309–318CrossRefPubMedGoogle Scholar
  28. Hoshino T, Sakisaka T, Baba T et al. (2005) Regulation of E-cadherin endocytosis by nectin through afadin, Rap1, and p120ctn. J Biol Chem 280:24095–24103CrossRefPubMedGoogle Scholar
  29. Ide N, Hata Y, Deguchi M et al. (1999) Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin. Biochem Biophys Res Commun 256:456–461CrossRefPubMedGoogle Scholar
  30. Iida J, Hirabayashi S, Sato Y et al. (2004) Synaptic scaffolding molecule is involved in the synaptic clustering of neuroligin. Mol Cell Neurosci 27:497–508CrossRefPubMedGoogle Scholar
  31. Ikeda W, Kakunaga S, Itoh S et al. (2003) Tage4/Nectin-like molecule-5 heterophilically trans-interacts with cell adhesion molecule nectin-3 and enhances cell migration. J Biol Chem 278:28167–28172CrossRefPubMedGoogle Scholar
  32. Inagaki M, Irie K, Deguchi-Tawarada M et al. (2003) Nectin-dependent localization of ZO-1 at puncta adhaerentia junctions between the mossy fiber terminals and the dendrites of the pyramidal cells in the CA3 area of adult mouse hippocampus. J Comp Neurol 460:514–524CrossRefPubMedGoogle Scholar
  33. Irie K, Shimizu K, Sakisaka T et al. (2004) Roles and modes of action of nectins in cell-cell adhesion. Semin Cell Dev Biol 15:643–656PubMedGoogle Scholar
  34. Jontes JD, Emond MR and Smith SJ (2004) In vivo trafficking and targeting of N-cadherin to nascent presynaptic terminals. J Neurosci 24:9027–9034CrossRefPubMedGoogle Scholar
  35. Kakunaga S, Ikeda W, Itoh S et al. (2005) Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes. J Cell Sci 118:1267–1277CrossRefPubMedGoogle Scholar
  36. Kanzaki N, Ogita H, Komura H et al. (2008) Involvement of the nectin-afadin complex in PDGF-induced cell survival. J Cell Sci 121:2008–2017CrossRefPubMedGoogle Scholar
  37. Katata T, Irie K, Fukuhara A et al. (2003) Involvement of nectin in the localization of IQGAP1 at the cell-cell adhesion sites through the actin cytoskeleton in Madin-Darby canine kidney cells. Oncogene 22:2097–2109CrossRefPubMedGoogle Scholar
  38. Kawakatsu T, Shimizu K, Honda T et al. (2002) Trans-interactions of nectins induce formation of filopodia and Lamellipodia through the respective activation of Cdc42 and Rac small G proteins. J Biol Chem 277:50749–50755CrossRefPubMedGoogle Scholar
  39. Kennedy J, Vicari AP, Saylor V et al. (2000) A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM). J Leukoc Biol 67:725–734PubMedGoogle Scholar
  40. Kuramochi M, Fukuhara H, Nobukuni T et al. (2001) TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Nat Genet 27:427–430CrossRefPubMedGoogle Scholar
  41. Ling K, Doughman RL, Firestone AJ et al. (2002) Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature 420:89–93CrossRefPubMedGoogle Scholar
  42. Luscher C, Nicoll RA, Malenka RC et al. (2000) Synaptic plasticity and dynamic modulation of the postsynaptic membrane. Nat Neurosci 3:545–550CrossRefPubMedGoogle Scholar
  43. Mandai K, Nakanishi H, Satoh A et al. (1999) Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions. J Cell Biol 144:1001–1017CrossRefPubMedGoogle Scholar
  44. Martel V, Racaud-Sultan C, Dupe S et al. (2001) Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides. J Biol Chem 276:21217–21227CrossRefPubMedGoogle Scholar
  45. Maurel P, Einheber S, Galinska J et al. (2007) Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination. J Cell Biol 178:861–874CrossRefPubMedGoogle Scholar
  46. Minami Y, Ikeda W, Kajita M et al. (2007a) Necl-5/poliovirus receptor interacts in cis with integrin αvβ 3 and regulates its clustering and focal complex formation. J Biol Chem 282:18481–18496CrossRefPubMedGoogle Scholar
  47. Minami Y, Ikeda W, Kajita M et al. (2007b) Involvement of up-regulated Necl-5/Tage4/PVR/CD155 in the loss of contact inhibition in transformed NIH3T3 cells. Biochem Biophys Res Commun 352:856–860CrossRefPubMedGoogle Scholar
  48. Mizoguchi A, Nakanishi H, Kimura K et al. (2002) Nectin: an adhesion molecule involved in formation of synapses. J Cell Biol 156:555–565CrossRefPubMedGoogle Scholar
  49. Mueller S, Cao X, Welker R et al. (2002) Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis. J Biol Chem 277:7897–7904CrossRefPubMedGoogle Scholar
  50. Nam CI and Chen L (2005) Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter. Proc Natl Acad Sci U S A 102:6137–6142CrossRefPubMedGoogle Scholar
  51. Nishimura W, Yao I, Iida J et al. (2002) Interaction of synaptic scaffolding molecule and Beta -catenin. J Neurosci 22:757–765PubMedGoogle Scholar
  52. Noritake J, Watanabe T, Sato K et al. (2005) IQGAP1: a key regulator of adhesion and migration. J Cell Sci 118:2085–2092CrossRefPubMedGoogle Scholar
  53. Ogita H and Takai Y (2008) Cross-talk among integrin, cadherin, and growth factor receptor: roles of nectin and nectin-like molecule. Int Rev Cytol 265:1–54CrossRefPubMedGoogle Scholar
  54. Ohno S (2001) Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity. Curr Opin Cell Biol 13:641–648CrossRefPubMedGoogle Scholar
  55. Okabe N, Shimizu K, Ozaki-Kuroda K et al. (2004) Contacts between the commissural axons and the floor plate cells are mediated by nectins. Dev Biol 273:244–256CrossRefPubMedGoogle Scholar
  56. Ooshio T, Irie K, Morimoto K et al. (2004) Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and alpha-actinin in epithelial cells. J Biol Chem 279:31365–31373CrossRefPubMedGoogle Scholar
  57. Ozaki M, Ogita H and Takai Y (2007) Involvement of integrin-induced activation of protein kinase C in the formation of adherens junctions. Genes Cells 12:651–662CrossRefPubMedGoogle Scholar
  58. Pellissier F, Gerber A, Bauer C et al. (2007) The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion. BMC Neurosci 8:90CrossRefPubMedGoogle Scholar
  59. Perez-Moreno M, Jamora C and Fuchs E (2003) Sticky business: orchestrating cellular signals at adherens junctions. Cell 112:535–548CrossRefPubMedGoogle Scholar
  60. Peters A, Palay SL and Webster Hd (1991) The fine structure of the nervous system : neurons and their supporting cells. Oxford University Press, New YorkGoogle Scholar
  61. Pokutta S, Drees F, Takai Y et al. (2002) Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin. J Biol Chem 277:18868–18874CrossRefPubMedGoogle Scholar
  62. Purpura DP (1974) Dendritic spine “dysgenesis” and mental retardation. Science 186:1126–1128CrossRefPubMedGoogle Scholar
  63. Reymond N, Fabre S, Lecocq E et al. (2001) Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction. J Biol Chem 276:43205–43215CrossRefPubMedGoogle Scholar
  64. Roh MH and Margolis B (2003) Composition and function of PDZ protein complexes during cell polarization. Am J Physiol Renal Physiol 285:F377–387PubMedGoogle Scholar
  65. Sakamoto Y, Ogita H, Hirota T et al. (2006) Interaction of integrin α(v)β 3 with nectin. Implication in cross-talk between cell-matrix and cell-cell junctions. J Biol Chem 281:19631–19644CrossRefPubMedGoogle Scholar
  66. Sakamoto Y, Ogita H, Komura H et al. (2008) Involvement of nectin in inactivation of integrin αvβ 3 after the establishment of cell-cell adhesion. J Biol Chem 283:496–505CrossRefPubMedGoogle Scholar
  67. Sakisaka T, Ikeda W, Ogita H et al. (2007) The roles of nectins in cell adhesions: cooperation with other cell adhesion molecules and growth factor receptors. Curr Opin Cell Biol 19:593–602CrossRefPubMedGoogle Scholar
  68. Sara Y, Biederer T, Atasoy D et al. (2005) Selective capability of SynCAM and neuroligin for functional synapse assembly. J Neurosci 25:260–270CrossRefPubMedGoogle Scholar
  69. Sato T, Fujita N, Yamada A et al. (2006) Regulation of the assembly and adhesion activity of E-cadherin by nectin and afadin for the formation of adherens junctions in Madin-Darby canine kidney cells. J Biol Chem 281:5288–5299CrossRefPubMedGoogle Scholar
  70. Satoh-Horikawa K, Nakanishi H, Takahashi K et al. (2000) Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. J Biol Chem 275:10291–10299CrossRefPubMedGoogle Scholar
  71. Scheiffele P, Fan J, Choih J et al. (2000) Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell 101:657–669CrossRefPubMedGoogle Scholar
  72. Shibuya K, Shirakawa J, Kameyama T et al. (2003) CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation. J Exp Med 198:1829–1839CrossRefPubMedGoogle Scholar
  73. Shingai T, Ikeda W, Kakunaga S et al. (2003) Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. J Biol Chem 278:35421–35427CrossRefPubMedGoogle Scholar
  74. Sorra KE, Fiala JC and Harris KM (1998) Critical assessment of the involvement of perforations, spinules, and spine branching in hippocampal synapse formation. J Comp Neurol 398:225–240CrossRefPubMedGoogle Scholar
  75. Spacek J (1985) Relationships between synaptic junctions, puncta adhaerentia and the spine apparatus at neocortical axo-spinous synapses. A serial section study. Anat Embryol (Berl) 173:129–135CrossRefGoogle Scholar
  76. Spiegel I, Adamsky K, Eshed Y et al. (2007) A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination. Nat Neurosci 10:861–869CrossRefPubMedGoogle Scholar
  77. Tachibana K, Nakanishi H, Mandai K et al. (2000) Two cell adhesion molecules, nectin and cadherin, interact through their cytoplasmic domain-associated proteins. J Cell Biol 150:1161–1176CrossRefPubMedGoogle Scholar
  78. Takahashi K, Nakanishi H, Miyahara M et al. (1999) Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein. J Cell Biol 145:539–549CrossRefPubMedGoogle Scholar
  79. Takai Y, Irie K, Shimizu K et al. (2003) Nectins and nectin-like molecules: roles in cell adhesion, migration, and polarization. Cancer Sci 94:655–667CrossRefPubMedGoogle Scholar
  80. Takai Y and Nakanishi H (2003) Nectin and afadin: novel organizers of intercellular junctions. J Cell Sci 116:17–27CrossRefPubMedGoogle Scholar
  81. Takai Y, Miyoshi J, Ikeda W et al. (2008) Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation. Nat Rev Mol cell Biol 9:603–615Google Scholar
  82. Takeichi M (1991) Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251:1451–1455CrossRefPubMedGoogle Scholar
  83. Takekuni K, Ikeda W, Fujito T et al. (2003) Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse. J Biol Chem 278:5497–5500CrossRefPubMedGoogle Scholar
  84. Togashi H, Abe K, Mizoguchi A et al. (2002) Cadherin regulates dendritic spine morphogenesis. Neuron 35:77–89CrossRefPubMedGoogle Scholar
  85. Togashi H, Miyoshi J, Honda T et al. (2006) Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery. J Cell Biol 174:141–151CrossRefPubMedGoogle Scholar
  86. Uchida N, Honjo Y, Johnson KR et al. (1996) The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones. J Cell Biol 135:767–779CrossRefPubMedGoogle Scholar
  87. Warner MS, Geraghty RJ, Martinez WM et al. (1998) A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus. Virology 246:179–189CrossRefPubMedGoogle Scholar
  88. Wyszynski M, Lin J, Rao A et al. (1997) Competitive binding of alpha-actinin and calmodulin to the NMDA receptor. Nature 385:439–442CrossRefPubMedGoogle Scholar
  89. Yageta M, Kuramochi M, Masuda M et al. (2002) Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer. Cancer Res 62:5129–5133PubMedGoogle Scholar
  90. Yamada A, Fujita N, Sato T et al. (2006a) Requirement of nectin, but not cadherin, for formation of claudin-based tight junctions in annexin II-knockdown MDCK cells. Oncogene 25:5085–5102CrossRefPubMedGoogle Scholar
  91. Yamada A, Irie K, Deguchi-Tawarada M et al. (2003) Nectin-dependent localization of synaptic scaffolding molecule (S-SCAM) at the puncta adherentia junctions formed between the mossy fibre terminals and the dendrites of pyramidal cells in the CA3 area of the mouse hippocampus. Genes Cells 8:985–994CrossRefPubMedGoogle Scholar
  92. Yamada A, Irie K, Hirota T et al. (2005) Involvement of the annexin II-S100A10 complex in the formation of E-cadherin-based adherens junctions in Madin-Darby canine kidney cells. J Biol Chem 280:6016–6027CrossRefPubMedGoogle Scholar
  93. Yamada D, Yoshida M, Williams YN et al. (2006b) Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule. Mol Cell Biol 26:3610–3624CrossRefPubMedGoogle Scholar
  94. Yamagata M, Herman JP and Sanes JR (1995) Lamina-specific expression of adhesion molecules in developing chick optic tectum. J Neurosci 15:4556–4571PubMedGoogle Scholar
  95. Yuste R and Bonhoeffer T (2001) Morphological changes in dendritic spines associated with long-term synaptic plasticity. Annu Rev Neurosci 24:1071–1089CrossRefPubMedGoogle Scholar
  96. Zhai RG, Vardinon-Friedman H, Cases-Langhoff C et al. (2001) Assembling the presynaptic active zone: a characterization of an active one precursor vesicle. Neuron 29:131–143CrossRefPubMedGoogle Scholar
  97. Ziv NE and Garner CC (2004) Cellular and molecular mechanisms of presynaptic assembly. Nat Rev Neurosci 5:385–399CrossRefPubMedGoogle Scholar

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Authors and Affiliations

  1. 1.Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular BiologyKobe University Graduate School of Medicine, 7-5-1 Kusunoki-choChuo-ku, KobeJapan

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