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Ephrins and Eph Receptor Tyrosine Kinases in Synapse Formation

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The Sticky Synapse

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Abstract

Here, we discuss what is known about the function of ephrins and Eph receptors in synapse formation in the peripheral nervous system and central nervous system. Ephrins have been shown to be present and functional at synapses at the neuromuscular junction and in the brain; evidence at the neuromuscular junction implicates ephrins in the topographic mapping of synapses on certain muscles. Also, certain Eph receptors also function in synapse formation but less information is known about them including their distribution and function. In addition, future directions are defined. Together, these data implicate ephrins, as well as Ephs, strongly in synaptic development.

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  1. Biologic and Materials Sciences, University of Michigan, 5211 Dental, 1011 N. University Ave., Ann Arbor, MI 48109-1078, USA

    Catherine E. Krull & Daniel J. Liebl

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  1. Catherine E. Krull
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  2. Daniel J. Liebl
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Correspondence to Catherine E. Krull .

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    Krull, C.E., Liebl, D.J. (2009). Ephrins and Eph Receptor Tyrosine Kinases in Synapse Formation. In: Umemori, H., Hortsch, M. (eds) The Sticky Synapse. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92708-4_16

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