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Ephrins and Eph Receptor Tyrosine Kinases in Synapse Formation

  • Catherine E. KrullEmail author
  • Daniel J. Liebl
Chapter
  • 710 Downloads

Abstract

Here, we discuss what is known about the function of ephrins and Eph receptors in synapse formation in the peripheral nervous system and central nervous system. Ephrins have been shown to be present and functional at synapses at the neuromuscular junction and in the brain; evidence at the neuromuscular junction implicates ephrins in the topographic mapping of synapses on certain muscles. Also, certain Eph receptors also function in synapse formation but less information is known about them including their distribution and function. In addition, future directions are defined. Together, these data implicate ephrins, as well as Ephs, strongly in synaptic development.

Keywords

Synaptogenesis Eph family PNS CNS 

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Biologic and Materials SciencesUniversity of Michigan, 5211 DentalAnn ArborUSA

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