Abstract
During the development of the nervous system, neurons must assemble a vast network of synaptic connections to form functional neuronal circuits. Each neuron sends axons to reach the general target region and then must choose the appropriate target from a multitude of neurons to make proper connections and to form synapses. How are such specific neuronal connections established? Sidekick proteins (Sdks) are synaptic adhesion molecules of the immunoglobulin (Ig) superfamily that have been suggested to mediate targeting specificity in the synaptic layers in the retina. These cell adhesion molecules, along with their close homologs, Down’s syndrome cell adhesion molecules (DSCAMs), provide a molecular code for lamina-specific synaptic connections that is governed by homophilic molecular interactions.
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Hong, Y.K., Yamagata, M. (2009). Molecular Basis of Lamina-Specific Synaptic Connections in the Retina: Sidekick Immunoglobulin Superfamily Molecules. In: Umemori, H., Hortsch, M. (eds) The Sticky Synapse. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92708-4_10
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DOI: https://doi.org/10.1007/978-0-387-92708-4_10
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