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A Short History of the Synapse – Golgi Versus Ramón y Cajal

  • Michael Hortsch
Chapter
The history of the synapse started not only as a struggle between two ideas but also as a feud between the two founding fathers of modern neuroscience, the Italian Camillo Golgi (1843–1926) and the Spaniard Santiago Ramón y Cajal (1851–1934). Preceding their groundbreaking portrayals of the nervous system structure, Robert Remak (1815–1865), Theodore Schwann (1810–1882), Otto Friedrich Karl Deiters (1834–1863), and others had published only rudimentary histological descriptions of nerves and of some other parts of the nervous system.

Keywords

Electrical Synapse Synaptic Signal Neuronal Synapse Silver Chromate Cellular Signaling Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Akert K, Moor H, Pfenninger K et al. (1969) Contributions of new impregnation methods and freeze etching to the problems of synaptic fine structure. In: Akert K and Waser PG (eds) Prog Brain Res. Elsevier Publishing Company, Amsterdam/London/New YorkGoogle Scholar
  2. Berlucchi G (1999) Some aspects of the history of the law of dynamic polarization of the neuron. From William James to Sherrington, from Cajal and van Gehuchten to Golgi. J Hist Neurosci 8:191–201CrossRefPubMedGoogle Scholar
  3. Connors BW and Long MA (2004) Electrical synapses in the mammalian brain. Annu Rev Neurosci 27:393–418CrossRefPubMedGoogle Scholar
  4. Dale HH (1914) The action of certain esters and ethers of choline. J Pharmacol 6:147–190Google Scholar
  5. De Robertis ED and Bennett HS (1955) Some features of the submicroscopic morphology of synapses in frog and earthworm. J Biophys Biochem Cytol 1:47–58Google Scholar
  6. Del Castillo J and Katz B (1954) Quantal components of the end-plate potential. J Physiol 124:560–573PubMedGoogle Scholar
  7. Eccles JC (1937) Synaptic and neuro-muscular transmission. Physiol Rev 17:538–555Google Scholar
  8. Elliott TR (1904) On the action of adrenalin. J Physiol 31(suppl.):XX–XXIGoogle Scholar
  9. Elliott TR (1905) The action of adrenalin. J Physiol 32:401–467PubMedGoogle Scholar
  10. Estable C, Reissig M and De Robertis E (1954) Microscopic and submicroscopic structure of the synapsis in the ventral ganglion of the acoustic nerve. Exp Cell Res 6:255–262CrossRefPubMedGoogle Scholar
  11. Ewins AJ (1914) Acetylcholine, a new active principle of ergot. Biochem J 8:44–49PubMedGoogle Scholar
  12. Fatt P and Katz B (1952) Spontaneous subthreshold activity at motor nerve endings. J Physiol 117:109–128PubMedGoogle Scholar
  13. Foster M and Sherrington CS (1897) A Text Book of Physiology. Macmillan and Co., New YorkGoogle Scholar
  14. Gerlach J (1872) Von dem Rückenmark. In: Stricker S (eds) Handbuch der Lehre von den Geweben des Menschen und der Thiere. Verlag von Wilhelm Engelmann, LeipzigGoogle Scholar
  15. Golgi C (1873) Suella struttura della sostanza grigia del cervello [On the structure of the brain grey matter]. Gazzetta Medica Italiana Lombarda 33:244–246Google Scholar
  16. Golgi C (1967) The Neuron Doctrine – Theory and Facts (Lecture delivered Decmber 11, 1906). In: (eds) Nobel Lectures, Physiology or Medicine 1901–1921. Elsevier Publishing Company, Amsterdam-London-New YorkGoogle Scholar
  17. Grakoui A, Bromley SK, Sumen C et al. (1999) The immunological synapse: a molecular machine controlling T cell activation. Science 285:221–227CrossRefPubMedGoogle Scholar
  18. Grant G (2007) How the 1906 Nobel Prize in Physiology or Medicine was shared between Golgi and Cajal. Brain Res Rev 55:490–498CrossRefPubMedGoogle Scholar
  19. His W (1889) Die Neuroblasten und deren Entstehung im Embryonalen Mark. Abhandlungen der mathematisch-physischen Classe der Königl. Sächsischen Gesellschaft der Wissenschaften 15:311–372Google Scholar
  20. Loewi O (1921) Über humorale Übertragbarkeit der Herznervenwirkung. I. Mitteilung. Pflüger’s Arch ges Physiol 189:239–242CrossRefGoogle Scholar
  21. Palay SL (1956) Synapses in the central nervous system. J Biophys Biochem Cytol 2:193–202PubMedCrossRefGoogle Scholar
  22. Ramón y Cajal S (1937) Recollections of my Life. M.I.T. Press, Cambridge, MAGoogle Scholar
  23. Ramón y Cajal S (1967) The structure and connexions of neurons (Lecture delivered December 12, 1906). In: (eds) Nobel Lectures, Physiology or Medicine 1901–1921. Elsevier Publishing Company, Amsterdam-London-New YorkGoogle Scholar
  24. Robertson JD (1953) Ultrastructure of two invertebrate synapses. Proc Soc Exp Biol Med 82:219–223PubMedGoogle Scholar
  25. Sjöstrand FS (1958) Ultrastructure of retinal rod synapses of the guinea pig eye as revealed by three-dimensional reconstructions from serial sections. J Ultrastruct Res 2:122–170CrossRefPubMedGoogle Scholar
  26. Tansey EM (1997) Not committing barbarisms: Sherrington and the synapse, 1897. Brain Res Bull 44:211–212CrossRefPubMedGoogle Scholar
  27. Tansey EM (2006) Henry Dale and the discovery of acetylcholine. C R Biol 329:419–425CrossRefPubMedGoogle Scholar
  28. von Euler US (1946) A specific sympathomimetric ergone in adrenergic nerve fibres (Sympathin) and its relations to adrenaline and nor-adrenaline. Acta Physiol Scand 12:73–97CrossRefGoogle Scholar
  29. von Koelliker A (1896) Handbuch der Gewebelehre des Menschen. Engelmann, LeipzigGoogle Scholar
  30. Waldeyer-Hartz W (1891) Ueber einige neuere Forschungen im Gebiete der Anatomie des Centralnervensystems. Deutsche medicinische Wochenschrift 17:1213–1218, 1244–1216, 1287–1219, 1331–1212 and 1350–1216Google Scholar
  31. Whitby LG, Axelrod J and Weil-Malherbe H (1961) The fate of H3-norepinephrine in animals. J Pharmacol Exp Ther 132:193–201PubMedGoogle Scholar
  32. Yamada S and Nelson WJ (2007) Synapses: sites of cell recognition, adhesion, and functional specification. Annu Rev Biochem 76:267–294CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Cell and Development BiologyUniversity of MichiganAnn ArborUSA

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