Abstract
The iatrogenicity of vitamin K antagonists is well established. Each year in France, vitamin K antagonists account for more than 17,000 hospital admissions and nearly 4000 deaths. Alternative treatment would be more than welcome. It is hard to imagine a drug that would induce more complications than a vitamin K antagonist.
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References
Bauer KA (2001) Fondaparinux sodium: a selective inhibitor of factor Xa. Am J Health Syst Pharm 58 (Suppl 2):S14–17
Turpie AG, Gallus AS, Hoek JA (2001) A synthetic pentasaccharide for the prevention of deepvein thrombosis after total hip replacement. N Engl J Med 344: 619–625
Turpie AG, Bauer KA, Eriksson BI, Lassen MR (2002) Fondaparinux vs enoxaparin for the prevention of venous thromboembolism in major orthopedic surgery: a meta-analysis of 4 randomized double-blind studies. Arch Intern Med 162: 1833–1840
Büller HR, Davidson BL, Decousus H, et al (2003) Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism. N Engl J Med 349: 1695–1702
Büller HR, Davidson BL, Decousus H, et al (2004) Fondaparinux or enoxaparin for the initial treatment of symptomatic deep venous thrombosis: a randomized trial. Ann Intern Med 140: 867–873
Mehta SR, Granger CB, Eikelboom JW, et al (2007) Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the OASIS-5 trial. J Am Coll Cardiol 50: 1742–1751
Warkentin TE, Maurer BT, Aster RH (2007) Heparin-induced thrombocytopenia associated with fondaparinux. N Engl J Med 356: 2653–2655
Buller HR, Cohen AT, Davidson B, et al (2007) Idraparinux versus standard therapy for venous thromboembolic disease. N Engl J Med 357: 1094–1104
Buller HR, Cohen AT, Davidson B, et al (2007) Extended prophylaxis of venous thromboembolism with idraparinux. N Engl J Med 357: 1105–1112
Bousser MG, Bouthier J, Buller HR, et al (2008) Comparison of idraparinux with vitamin K antagonists for prevention of thromboembolism in patients with atrial fibrillation: a randomised, open-label, non-inferiority trial. Lancet 371: 315–321
Weitz JI, Hirsh J, Samama MM (2004) New anticoagulant drugs: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126:265S–286S
Weitz JI, Bates SM. New anticoagulants. J Thromb Haemost 2005;3: 1843–53
Eriksson BI, Borris LC, Dahl OE, et al (2006) A once-daily, oral, direct Factor Xa inhibitor, rivaroxaban (BAY 59-7939), for thromboprophylaxis after total hip replacement. Circulation 114: 2374–2381
Lassen MR, Ageno W, Borris LC, et al (2008) Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med 358: 2776–2786
Eriksson BI, Borris LC, Friedman RJ, et al (2008) Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty. N Engl J Med 358: 2765–2775
Lassen MR, Davidson BL, Gallus A, Pineo G, Ansell J, Deitchman D (2007) The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement. J Thromb Haemost 5: 2368–2375
Weitz JI (2007) Factor Xa or thrombin: is thrombin a better target? J Thromb Haemost 5 (Suppl 1): 65–67
Eriksson BI, Dahl OE, Buller HR, Hettiarachchi R (2005) A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO II randomized trial. J Thromb Haemost 3: 103–111
Eriksson B, Dahl O, Rosencher N, et al (2007) Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the REMODEL randomized study. J Thromb Haemost 5: 2178–2185
Eriksson BI, Dahl OE, Rosencher N, Kurth AA (2007) Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial. Lancet 370: 949–956
The RE-MOBILIZE Writing Committee (2009) Oral thrombin inhibitor dabigatran etexilate vs the North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery. J Arthroplasty 24: 1–9
Gross PL, Weitz JI (2008) New anticoagulants for treatment of venous thromboembolism. Arterioscler Thromb Vasc Biol 28: 380–386
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Samama, C.M. (2009). New Anticoagulants: Anti-IIa or Anti-Xa Agents?. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92278-2_70
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DOI: https://doi.org/10.1007/978-0-387-92278-2_70
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