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Measurement of Carbon Monoxide: From Bench to Bedside

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Intensive Care Medicine

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Abstract

Carbon monoxide is produced endogenously by the class of enzymes known collectively as heme oxygenase (HO) [1]. The inducible form of HO, HO-1, has been reported to have cytoprotective and anti-oxidant activities [1]. In addition, other studies have suggested that endogenously generated carbon monoxide has protective and beneficial effects on a vast array of responses against multiple organ injury, inflammation, apoptosis, cell proliferation, vasoconstriction and systemic and pulmonary hypertension [2–5]. The initial evidence supporting a beneficial action of carbon monoxide originated from studies on lung injury in animals [6] and was reproduced later in other tissues, including the heart, liver, kidney, intestine and the reticulo-endothelial system [2, 7].

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Authors and Affiliations

  1. Department of Anesthesiology and Intensive Care, Friedrich-Schiller University, Erlanger Allee 103, 07743 Jena, Germany

    F. Corrêa, F. E. Nacul & Y. Sakr

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  1. F. Corrêa
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Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Universitée libre de Bruxelles, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Head) (Head)

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Corrêa, F., Nacul, F.E., Sakr, Y. (2009). Measurement of Carbon Monoxide: From Bench to Bedside. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92278-2_7

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  • DOI: https://doi.org/10.1007/978-0-387-92278-2_7

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