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Neutrophil Gelatinase-associated Lipocalin: An Emerging Biomarker for Angina Renalis

  • P. Devarajan

Abstract

Angina pectoris is symptomatic, and sensitive biomarkers such as troponin that are released from affected myocytes have revolutionized the early diagnosis and successful treatment of ischemic myocardial injury. In contrast, ischemic acute kidney injury (AKI), analogously referred to as angina renalis, is largely devoid of symptoms. Although common and serious (about one-third of intensive care patients develop AKI), the diagnosis using conventional biomarkers such as serum creatinine is unreliable and delayed [1]. Therefore, potentially effective interventions are delayed, and AKI remains an important contributor to the high mortality rate in affected critically ill subjects [2, 3]. Fortunately, recent advances have unraveled the early stress response of kidney tubule cells to ischemic injury, and have provided several novel biomarkers for AKI [4, 5, 6]. The current status of neutrophil gelatinase-associated lipocalin (NGAL), possibly the most promising AKI biomarker in intensive care and emergency medicine settings, is outlined below.

Keywords

Chronic Kidney Disease Acute Kidney Injury Delay Graft Function Adult Cardiac Surgery Angina Renalis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • P. Devarajan
    • 1
  1. 1.Department of Nephrology and Hypertension Cincinnati Children’s Hospital Medical CenterUniversity of CincinnatiCincinnatiUSA

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